Screening for Specific Inhibitors of Phagocytosis of Thioglycollate-elicited Macrophages

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概要

• 論文の詳細を見る

• Phagocytosis is one of the basic and characteristic properties of macrophages. We screened metabolites of Actinomyces for low molecular weight substances that selectively inhibited phagocytosis of dried yeast but not pinocytosis of neutral red by thioglycollate-elicited peritoneal macrophages. Inhibitors of actin filament organization, protein kinases, respiration, and lipid synthesis selectively inhibited phagocytosis, and blockers of proton gradients selectively inhibited pinocytosis. This suggests that these functions are differently regulated. We applied this system to screening of metabolites of Actinomyces, and identified mycotrienin, piericidin, and genistein as selective inhibitors of phagocytosis.

• 社団法人日本農芸化学会の論文
• 1994-01-23

著者

• Magae Junji

  Radiation Safety Research Center, Central Institute of Electric Power Industry

• URAMOTO Masakazu

  Faculty of Agriculture, Tamagawa University

• KATAOKA Takao

  Department of Bioengineering, Tokyo Institute of Technology

• MAGAE Junji

  Department of Bioengineering, Tokyo Institute of Technology

• NAGAI Kazuo

  Department of Bioengineering, Tokyo Institute of Technology

• Magae J

  Tokyo Inst. Technol. Yokohama Jpn

• Magae Junji

  京都府立医科大学 麻酔学

• Magae Junji

  Dep. Of Biotechnology Inst. Of Res. And Innovation

• Magae Junji

  Radiation Safety Research Center Central Institute Of Electric Power Industry

• Magae J

  Inst. Res. And Innovation Kashiwa Jpn

• Kataoka T

  Tokyo Inst. Technol. Yokohama Jpn

• Kataoka Takao

  東京工業大学

• Uramoto M

  Riken (the Institute Of Physical And Chemical Research)

• Uramoto M

  Tamagawa Univ. Tokyo Jpn

• Uramoto M

  Department Of Applied Biological Chemistry Tamagawa University

• KOSHINO Hiroyuki

  RIKEN

• Kudo T

  Inst. Physical And Chemical Res. (riken) Saitama Jpn

• Ueki Masashi

  Riken Institute

• URAMOTO Masakazu

  The Institute of Physical and Chemical Research

• Uramoto Masakazu

  Faculty Of Agriculture Tamagawa University Tamagawa Gakuen

• Uramoto Masakazu

  Faculty Of Agriculture Tamagawa University

• Nagai Kazuo

  Department Of Applied Biological Chemistry Chubu University

• Nagai K

  Chubu Univ. Aichi Jpn

• Nagi Toshimi

  Department of Bioengineering, Tokyo Institute of Technology

• Takaku Kazuaki

  Department of Bioengineering, Tokyo Institute of Technology

• Koshino H

  Riken (the Inst. Physical And Chemical Res.) Saitama Jpn

• Koshino Hiroyuki

  Department Of Agricultural Chemistry Faculty Of Agriculture Hokkaido University:(present Address) Ri

• Koshino Hiroyuki

  Molecular Characterization Characterization Center Riken(the Institute Of Physical And Chemical Rese

• Kataoka Takao

  Department Of Bioengineering Tokyo Institute Of Technology

• Nagi Toshimi

  Department Of Bioengineering Tokyo Institute Of Technology

• Koshino Hiroyuki

  Advanced Science Institute Riken

• Kataoka Takao

  Department Of Applied Biology Kyoto Institute Of Technology

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