Fas Ligand Released by Activated Monocytes Causes Apoptosis of Lung Epithelial Cells in Human Acute Lung Injury Model in Vitro(Molecular and Cell Biology)

スポンサーリンク

概要

• 論文の詳細を見る

• Alveolar epithelial cell death plays a crucial role in the progression of acute lung injury. We have demonstrated up-regulation of Fas expression on alveolar epithelial cells, and soluble Fas ligand secretion from inflammatory cells upon acute lung injury. Here we show that the lipopolysaccharide-stimulated human monocyte cell line THP-1 releases Fas ligand, and that conditioned medium from lipopolysaccharide-stimulated THP-1 cells induces apoptosis of the human pulmonary adenocarcinoma cell line A549. Activation of caspase-3 and -8 is associated with the apoptosis. Gene targeting on Fas in A549 cells by specific small interfering RNA impairs apoptosis induced by conditioned medium from activated THP-1, while that on Fas ligand in THP-1 cells impairs the apoptosis-inducing activity of the conditioned medium produced by lipopolysaccharide-stimulated cells. These results suggest that Fas ligand released by monocytes causes alveolar epithelial cell death through a Fas-dependent apoptotic mechanism in the development of acute lung injury.

• 公益社団法人日本薬学会の論文
• 2008-03-01

著者

• Nakajima Hiroo

  Tsujigiwa Daigo Clinic

• Mizuta Naruhiko

  Department of Endocrine and Breast Surgery, Kyoto Prefectural University of Medicine

• Magae Junji

  Radiation Safety Research Center, Central Institute of Electric Power Industry

• Tanuma Sei-ichi

  Department of Biochemistry, Tokyo University of Science

• Magae Junji

  京都府立医科大学 麻酔学

• Magae Junji

  Dep. Of Biotechnology Inst. Of Res. And Innovation

• Magae Junji

  Radiation Safety Research Center Central Institute Of Electric Power Industry

• Magae J

  Inst. Res. And Innovation Kashiwa Jpn

• Nakajima Hiroo

  京都府立医科大学 内分泌･乳腺外科学部門

• Nakajima Hiroo

  Department Of Radiation Biology And Medical Genetics Graduate School Of Medicine Osaka University

• Mizuta Naruhiko

  京都府立医科大学 内分泌･乳腺外科学部門

• Mizuta Naruhiko

  Department Of Endocrine And Breast Surgery Kyoto Prefectural University Of Medicine

• Tanuma Sei-ichi

  東京理科大学 薬学部生化学

• Tanuma Sei-ichi

  京都府立医科大学 内分泌･乳腺外科学部門

• Tanuma Sei-ich

  Department Of Biochemistry Faculty Of Pharmaceutical Sciences Tokyo University Of Science

• Ishizaka Akitoshi

  Division of Pulmonary Medicine, Department of Medicine, Keio University School of Medicine

• Tanuma S

  Department Of Biochemistry Tokyo University Of Science

• Magae J

  Department Of Biotechnology Institute Of Research And Innovation (iri)

• Ishizaka Akitoshi

  Division Of Pulmonary Medicine Department Of Internal Medicine School Of Medicine Keio University

• Tanuma S

  Department Of Biochemistry Faculty Of Pharmaceutical Sciences Science University Of Tokyo

• Tanuma Sei-ichi

  Department Of Electronics Faculty Of Technology Gunma University:department Of Materials Science Iwa

• MIZUTA Mitsuhiko

  Department of Anesthesiology and Intensive Care, Kyoto Prefectural University of Medicine

• KITAMURA Yoshihiro

  Department of Anesthesiology and Intensive Care, Kyoto Prefectural University of Medicine

• NAKAJIMA Yasufumi

  Department of Anesthesiology and Intensive Care, Kyoto Prefectural University of Medicine

• HASHIMOTO Soshi

  Department of Anesthesiology and Intensive Care, Kyoto Prefectural University of Medicine

• MATSUYAMA Hiroki

  Department of Anesthesiology and Intensive Care, Kyoto Prefectural University of Medicine

• SHIME Nobuaki

  Department of Anesthesiology and Intensive Care, Kyoto Prefectural University of Medicine

• AMAYA Fumimasa

  Department of Anesthesiology and Intensive Care, Kyoto Prefectural University of Medicine

• KOH Hidefumi

  Division of Pulmonary Medicine, Department of Internal Medicine, School of Medicine, Keio University

• TANUMA Sei-ich

  Genome and Drug Research Center

• HASHIMOTO Satoru

  Department of Anesthesiology and Intensive Care, Kyoto Prefectural University of Medicine

• Koh Hidefumi

  Division Of Pulmonary Medicine Department Of Internal Medicine School Of Medicine Keio University

• Shime Nobuaki

  Department Of Anesthesiology And Intensive Care Kyoto Prefectural University Of Medicine

• Amaya Fumimasa

  Department Of Anesthesiology And Intensive Care Kyoto Prefectural University Of Medicine

• Hashimoto Soshi

  Department Of Anesthesiology And Intensive Care Kyoto Prefectural University Of Medicine

• Matsuyama Hiroki

  Department Of Anesthesiology And Intensive Care Kyoto Prefectural University Of Medicine

• Nakajima Yasufumi

  Department Of Anesthesiology And Department Of Physiology Kyoto Prefectural University Of Medicine

• Mizuta Naruhiko

  辻際醍醐診療所

• Kitamura Yoshihiro

  Department Of Anesthesiology And Intensive Care Kyoto Prefectural University Of Medicine

• Mizuta Mitsuhiko

  Department Of Anesthesiology And Intensive Care Kyoto Prefectural University Of Medicine

• Hashimoto Satoru

  Department Of Anesthesiology And Intensive Care Kyoto Prefectural University Of Medicine

• TANUMA Sei-ichi

  The Institute for Solid State Physics, The University of Tokyo

• ISHIZAKA Akitoshi

  Division of Pulmonary Medicine, Department of Internal Medicine, School of Medicine, Keio University

関連論文

• Enhancement of paclitaxel-induced apoptosis in HER2-overexpressing human breast cancer cells by a pertuzumab mimetic peptide, HRAP(MEDICAL BIOTECHNOLOGY)
• Selective Induction of Interleukin-1 Production and Tumor Killing Activity of Macrophages Through Apoptosis by the Inhibition of Oxidative Respiration
• Suppression of T Cell Stimulating Function of Allogeneic Antigen Presenting Cells by Prodigiosin 25-C
• Immunosuppressive Activity of Streptonigrin in Vitro and in Vivo
• Prodigiosin 25-C Perturbs Permeation of Acetate in a Cultured Cell Line
• Presentation of Exogenous Antigen by Macrophages But Not by Spleen Cells Is Inhibited by Leupeptin and Antipain
• Development and Characterization of Macrophage Hybridomas Derived from Murine Peritoneal Exudate Cells
• Effects of Microbial Products on Glucose Consumption and Morphology of Macrophages
• Melastin, a Novel Product of Streptomyces That Selectively Inhibits Leukemia Cell Growth
• Morphological Changes and Reorganization of Actinfilaments in Human Myeloid Leukemia Cells Induced by a Novel Protein Phosphatase Inhibitor, Tautomycin
• Effects of L-156,602,a C5a Receptor Antagonist, on Mouse Experimental Models of Inflammation
• Preferential Suppression of Delayed-type Hypersensitivity by L-156,602,a C5a Receptor Antagonist
• A Novel in Vivo Screening Method for Immunomodulating Substances : Development of an Assay System
• Germ-Line Mutations at a Mouse ESTR (Pc-3) Locus and Human Microsatellite Loci
• 135 Transgenerational Mutations in the Children of the Liquidators Who Worked for the Chernobyl Nuclear Power Plant Accident(Effects of radiation exposures, Abstracts of the 46th Annual Meeting of the Japan Radiation Research Society)
• Bioloical condensation of radionuclides in the contaminated areas after Chelnobyl catastrophe
• Paramagnetic Susceptibility of 1T-TaS_2 and 1T-TaS_Se_ in Aderson Localized States
• Anderson Localization and Crystalline Defects of 1T-TaS_2
• T^2-Dependence of Electrical Resistivity in TiS_2 and ZrSe_2
• Electrical Properties of Lithium Intercalated TiS_2,ZrSe_2,HfSe_2,1T-TaS_2 and VSe_2
• Electrochemical Characteristics of TiS_2, ZrSe_2 and VSe_2 in Secondary Lithium Battery
• Paramagnetic Property in the Commensurate Charge Density Wave Phase of 1T-TaS_2
• Amyloid precursor protein binding protein Fe65 is cleaved by caspases during DNA damage-induced apoptosis
• Visualizing Nuclear Migration during Conidiophore Development in Aspergillus nidulans and Aspergillus oryzae : Multinucleation of Conidia Occurs through Direct Migration of Plural Nuclei from Phialides and Confers Greater Viability and Early Germination i
• Effects of Protein Transport Inhibitors on the Distribution and Secretion of the Fusion Protein RntA-EGFP in Aspergillus oryzae
• In vivo Visualization of the Distribution of a Secretory Protein in Aspergillus oryzae Hyphae Using the RntA-EGFP Fusion Protein(Microbiology & Fermentation Technology)
• Visualization of Nuclei in Aspergillus oryzae with EGFP and Analysis of the Number of Nuclei in Each Conidium by FACS(Microbiology & Fermentation Technology)
• Production and Product Quality Assessment of Human Hepatitis B Virus Pre-S2 Antigen in Submerged and Solid-State Cultures of Aspergillus oryzae
• Glycogen Synthase Kinase-3β2 Has Lower Phosphorylation Activity to Tau than Glycogen Synthase Kinase-3β1
• Amyloid Precursor Protein Binding Protein Fe65 Is Cleaved by Caspases during DNA Damage-Induced Apoptosis
• PPARγ Activation and Adipocyte Differentiation Induced by AS-6, a Prenyl-phenol Antidiabetic Antibiotic
• Development of HER2-antagonistic peptides as novel anti-breast cancer drugs by in silico methods
• Genomic Drug Discovery for Apoptosis Regulation Using a New Computer Screening Amino Acid Complement Wave Method(Mitochondria and Neuroprotection)
• Structure-Activity Relationship within a Series of Degradation Products of Tautomycin
• Epiderstatin and Its Related Glutarimide Antibiotics Inhibit the Cell Growth Induced by Mitogen Stimulation(Biological Chemistry)
• Synthesis and Biological Activity of Aminoacyl Analogs of Ascamycin(Organic Chemistry)
• The Involvement of ATP Produced via (ADP-Ribose)_n in the Maintenance of DNA Replication Apparatus during DNA Repair(Molecular and Cell Biology)
• Checkpoint Kinase 1 Is Cleaved in a Caspase-Dependent Pathway during Genotoxic Stress-Induced Apoptosis(Molecular and Cell Biology)
• Two-Dimensional Localization Effect with Spin-Orbit Scattering in Arsenic Doped Polycrystalline Silicon Films
• A Hall Element Yielding a Precise Field-Linear Hall Voltage up to a High-Field Region : Semiconductors and Semiconductor Devices
• BIOLOGICAL IMPLICATIONS OF APOPTOSIS/APOBIOSIS IN SENESCENCE AND LIFE-SPAN
• Cyclotron Resonance in Deformed Lead Crystals
• Innate Apoptosis of Human B Lymphoblasts Transformed by Epstein-Barr Virus : Modulation by Cellular Immortalization and Senescence
• A Novel SCID Technology for Biomedical Studies in Human Tissues
• Sensitivity of the SCID fibroblasts to high and low dose rate gamma rays and damage recovery.
• Cloning and Overexpression of β-N-Acetylglucosaminidase Encoding Gene nagA from Aspergillus oryzae and Enzyme-catalyzed Synthesis of Human Milk Oligosaccharide(Microbiology & Fermentation Technology)
• Cloning and Characterization of the nagA Gene that Encodes β-N-Acetylglucosaminidase from Aspergillus nidulans and Its Expression in Aspergillus oryzae(Microbiology & Fermentation Technology)
• Fas Ligand Released by Activated Monocytes Causes Apoptosis of Lung Epithelial Cells in Human Acute Lung Injury Model in Vitro(Molecular and Cell Biology)
• Identification of Low Molecular Weight Probes on Perforin- and Fas-based Killing Mediated by Cytotoxic T Lymphocytes
• Costunolide and Dehydrocostus Lactone as Inhibitors of Killing Function of Cytotoxic T LymPhocytes
• 1'-Acetoxychavicol Acetate as an Inhibitor of Phagocytosis of Macrophages
• Prodigiosin 25-C Suppression of Cytotoxic T Cells in Vitro and in Vivo Similar to That of Concanamycin B, a Specific Inhibitor of Vacuolar Type H^+-ATPase
• Screening for Specific Inhibitors of Phagocytosis of Thioglycollate-elicited Macrophages
• Differentiation of Mouse and Human Myeloid Leukemia Cells Induced by an Antitumor Antibiotic, Ascofuranone(Biological Chemistry)
• A Case of Non-Metastatic Giant Mucinous Carcinoma of the Breast
• Aberrant Expression of Fra-1 in Estrogen Receptor-negative Breast Cancers and Suppression of their Propagation In Vivo by Ascochlorin, an Antibiotic that Inhibits Cellular Activator Protein-1 Activity
• Radiation-induced Mutations in Human Thyroid Tissues Maintained in the Improved SCID Mice.
• Biosyntheses of Sescandelin and Sescandelin B : New Isocoumarin Compounds Produced by the Fungus, Sesquicilium candelabrum
• Importance of the Ketone Function for the Phytotoxicity of Spiciferone A, a Phytotoxin Produced by the Fungus Cochliobolus spicifer
• BSF-A, a New Plant Growth Regulator Produced by the Fungus, Botrytis squamosa
• Dihydroampullicin, a New Plant Growth Regulators Produced by the Ampulliferina-like Fungus sp. No.27
• Altechromones A and B, New Plant Growth Regulators Produces by the Fungus, Alternaria sp.
• Absolute Stereochemistry of Neovasinin, a Phytotoxin Produced by the Fungus, Neocosmospora vasinfecta
• Structure and Biological Activity of Plant Growth Regulators Produced by Penicillium
• Hericerin, a New Pollen Growth Inhibitor from the Mushroom Hericium erinaceum(Organic Chemistry)
• Structure of Sescandelin-B, a New Metabolite Produced by the Fungus, Sesquicillium candelabrum(Organic Chemistry)
• Vulculic Acid, a Pollen Germination Inhibitor Produced by the Fungus, Penicillium sp.(Organic Chemistry)
• Sescandelin, a New Root Promoting Substance Produced by the Fungus, Sesquicillium candelabrum(Organic Chemistry)
• Ampullicin and Isoampullicin, New Metabolites from an Ampulliferina-like Fungus sp. No.27(Organic Chemistry)
• Structure of Spiciferone A, a Novel γ-Pyrone Plant Growth Inhibitor Produced by the Fungus Cochliobolus spicifer Nelson(Organic Chemistry)
• Production of Cyclosporin by Fungi Belonging to the Genus Neocosmospora(Biological Chemistry)
• Structure of Rosellichalasin, a New Metabolite Produced by Rosellinia necatrix(Organic Chemistry)
• Isolation and Structures of O-Methyldihydrobotrydial and Deacetyl-O-methyldihydrobotrydialone Produced by Botrytis squamosa(Organic Chemistry)
• Isolation of 2-Acetylamino-3-hydroxy-4-methyloct-6-enoic Acid, a Derivative of the "C_9-Amino Acid" Residue of Cyclosporins, Produced by the Fungus Neocosmospora vasinfecta E. F. Smith(Organic Chemistry)
• Magneto-Phonon Effect in the Longitudinal Magnetoresistance of Bismuth (Selected Topics in Semiconductor Physics) -- (Transport)
• Structural Phase Transition in Stage 2 SbCl_5-Graphite Intercalation Compound
• Immunosuppressive Activity of 4-O-Methylascochlorin
• Elimination of Cell-cycle Regulators during Caspase-3-dependent Apoptosis Caused by an Immunosuppressant, FTY720(Biochemistry & Molecular Biology)
• Sequential maintenance of the solitary and hereditary colorectal polyps in SCID mice and ras oncogene mutations.
• A New Antimitotic Substance, FR182877 : II. The Mechanism of Action
• New Antitumor Substances, FR901463, FR901464 and FR901465 II. Activities against Experimental Tumors in Mice and Mechanism of Action
• Control with Organic Solvents of Efficiency of Persolvent Cholesterol Fermentation by Pseudomonas sp. Strain ST-200
• soxRS Gene Increased the Level of Organic Solvent Tolerance in Escherichia coli
• A Close Correlation between Improvement of Organic Solvent Tolerance Levels and Alteration of Resistance toward Low Levels of Multiple Antibiotics in Escherichia coli
• Action of FR901228, a Novel Antitumor Bicyclic Depsipeptide Produced by Chromobacterium violaceum No. 968, on Ha-ras Transformed NIH3T3 Cells
• Isolation, X-Ray Structure and Biological Activity of Deacetyl-dihydrobotrydial Produced by Botrytis squamosa
• Induced Torque of SbCl_5-Graphite Intercalation Compounds
• Magnetic Susceptibility of SbCl_5-Graphite Intercalation Compounds
• Bi_Sb_ 合金の熱流磁気効果の磁場依存性
• De Haas-van Alphen Effect of SbCl_5-Graphite Intercalation Compounds.I
• De Haas-van Alphen Effect of SbCl_5-Graphite Intercalation Compounds.II
• Expression of an 87-kD-β-1,3-Glucanase of Bacillus circulans IAM1165 in Saccharomyces cerevisiae by Low-temperature Incubation
• Effective Isolation and Identification of Toluene-tolerant Pseudomonas Strains
• Structures of Naphthoquinones Produced by the Fungus, Fusarium sp., and Their Biological Activity toward Pollen Germination(Organic Chemistry)
• Structure of Neovasinone, a New α-Pyrone Plant Growth Regulator Produced by the Fungus, Neocosmospora vasinfecta E. F. Smith(Organic Chemistry)
• Subcutaneous Arginine Administration Causes Apoptosis of Rat Pancreas
• DNA FRAGMENTATION IN APOPTOSIS
• Cladribine Enhances Apoptotic Cell Death in Lung Carcinoma Cells Over-Expressing DNase γ
• Relationship between peroxisome proliferator-activated receptor-γ activation and the ameliorative effects of ascochlorin derivatives on type II diabetes
• Stereochemistry and Biological Activities of LL-P880γ, a Pestalotin Analogue, Produced by Penicillium citreo-viride

もっと見る 閉じる

スポンサーリンク