A Close Correlation between Improvement of Organic Solvent Tolerance Levels and Alteration of Resistance toward Low Levels of Multiple Antibiotics in Escherichia coli

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概要

• 論文の詳細を見る

• We have isolated cyclohexane-tolerant mutants from Escherichia coli strain JA300, which is cyclohexane-sensitive and n-hexane-tolerant. These mutants were resistant to low levels of ampicillin, chloramphenicol, nalidixic acid, and tetracycline, and were sensitive to a low level of kanamycin. Spontaneous clones resistant to low levels of the antibiotics, isolated from JA300, showed altered levels of organic solvent tolerance. The clones resistant to ampicillin and chloramphenicol had cyclohexane tolerance. Some of the resistant clones had cyclohexane and n-pentane tolerances. On the other hand, some kanamycin resistant clones became sensitive to n-hexane. Therefore, mechanisms to improve tolerance levels toward organic solvents are closely correlated with some antibiotic resistant system to low levels of antibiotics.

• 社団法人日本農芸化学会の論文
• 1995-02-23

著者

• Kobayashi Miki

  Biochemicals Laboratory Mitsubishi Chemical Corporation

• Kobayashi Hideki

  Department of Internal Medicine and Molecular Science, Graduate School of Medicine, Osaka University

• Nakajima Hiroo

  京都府立医科大学 内分泌･乳腺外科学部門

• Kawano H

  Extremobiosphere Research Center (xbr) Japan Agency For Marine-earth Science And Technology (jamstec

• Nakajima Hiroo

  Tsujigiwa Daigo Clinic 1-19 Daigo Shinmachi-uramachi Fushimi-ku Kyoto 601-1326 Jpn

• NAKAJIMA Harushi

  Department of Biotechnology, The University of Tokyo

• Aono R

  Tokyo Inst. Technol. Yokohama Jpn

• KOBAYASHI Masato

  Department of Electronics, Kyushy University

• AONO Rikizo

  Department of Bioengineering, Faculty of Bioscience and Biotechnology, Tokyo Institute of Technology

• Kobayashi Masatomo

  Inst. Phys. Chem. Res. (riken)

• Kobayashi M

  Graduate School Of Pharmaceutical Sciences Osaka University

• Nakajima H

  Department Of Endocrine Breast Surgery Kyoto Prefectural University Of Medicine

• Kobayashi M

  Carbohydrate Science Laboratory National Food Research Institute Ministry Of Agriculture Forestry An

• Aono Rikizo

  Department Of Bioengineering Faculty Of Bioscience And Biotechnology Tokyo Institute Of Technology

• Horikoshi K

  Extremobiosphere Res. Center (xbr) Japan Agency For Marine-earth Sci. And Technol. (jamstec)

• Nakajima Harushi

  Department Of Agricultural Chemistry The University Of Tokyo

• Nakajima Hidenori

  Exploratory Research Laboratories Fujisawa Pharmaceutical Co. Ltd

• Kobayashi Hideki

  Department Of Cardiology Tokyo Metropolitan Fuchu Hospital

• Aono Rikizo

  Department Of Bioengineering Faculty Of Bioscience And Biotechnology Tokyo Institute Of Techanology

• Kobayashi Masato

  Department Of Bioengineering Tokyo Institute Of Technology

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