Costunolide and Dehydrocostus Lactone as Inhibitors of Killing Function of Cytotoxic T LymPhocytes

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概要

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• Costunolide and dehydrocostus lactone were isolated from an extract of mokko (Saussurea lappa Clarke) as inhibitors of killing activity of cytotoxic T lymphocytes (CTL). Mokko lactone was also isolated as an inactive compound from the extract. The structure-activity relationship indicated that α-methylene-γ-butyrolactone is required for the inhibitory effect. Costunolide markedly inhibited the granule exocytosis and the production of inositol phosphates in response to anti-CD3 monoclonal antibody (mAb) stimulation at a concentration that did not affect the binding of anti-CD3 mAb. Tyrosine phosphorylation induced by crosslinking of CD3 molecules was significantly inhibited by costunolide in a dose-dependent manner. These results suggest that costunolide inhibits the killing activity of CTL through preventing the increase in tyrosine phosphorylation in response to the crosslinking of T-cell receptors.

• 社団法人日本農芸化学会の論文
• 1995-11-23

著者

• Magae Junji

  Radiation Safety Research Center, Central Institute of Electric Power Industry

• URAMOTO Masakazu

  Faculty of Agriculture, Tamagawa University

• KATAOKA Takao

  Department of Bioengineering, Tokyo Institute of Technology

• MAGAE Junji

  Department of Bioengineering, Tokyo Institute of Technology

• NAGAI Kazuo

  Department of Bioengineering, Tokyo Institute of Technology

• SUZUKI Hidefumi

  Department of Bioengineering, Tokyo Institute of Technology

• Magae J

  Tokyo Inst. Technol. Yokohama Jpn

• Magae Junji

  京都府立医科大学 麻酔学

• Magae Junji

  Dep. Of Biotechnology Inst. Of Res. And Innovation

• Magae Junji

  Radiation Safety Research Center Central Institute Of Electric Power Industry

• Magae J

  Inst. Res. And Innovation Kashiwa Jpn

• Kataoka T

  Tokyo Inst. Technol. Yokohama Jpn

• Kataoka Takao

  東京工業大学

• Uramoto M

  Riken (the Institute Of Physical And Chemical Research)

• Uramoto M

  Tamagawa Univ. Tokyo Jpn

• Uramoto M

  Department Of Applied Biological Chemistry Tamagawa University

• Kudo T

  Inst. Physical And Chemical Res. (riken) Saitama Jpn

• Ueki Masashi

  Riken Institute

• URAMOTO Masakazu

  The Institute of Physical and Chemical Research

• NISHIMURA Toshio

  Department of Pathology, Kansai Medical University

• Uramoto Masakazu

  Faculty Of Agriculture Tamagawa University Tamagawa Gakuen

• Uramoto Masakazu

  Faculty Of Agriculture Tamagawa University

• Nagai K

  Yamanouchi Pharmaceutical Co. Ltd. Tokyo Jpn

• Nagai Kazuo

  Department Of Applied Biological Chemistry Chubu University

• Nagai K

  Chubu Univ. Aichi Jpn

• OTAKE Noboru

  Department of Biosciences, School of Science and Engineering, Teikyo University

• TANIGUCHI Masatoshi

  Department of Bioengineering, Tokyo Institute of Technology

• Ando Masayoshi

  Department of Applied Chemistry, Niigata University

• Arao Kei

  Department of Applied Chemistry, Niigata University

• Kataoka Takao

  Department Of Bioengineering Tokyo Institute Of Technology

• Taniguchi Masatoshi

  Department Of Applied Biology Kyoto Institute Of Technology

• Suzuki H

  Kirin Brewery Co. Ltd. Takasaki Jpn

• Arao Kei

  Department Of Applied Chemistry Niigata University

• Otake Noboru

  Department Of Science And Technology Teikyo University

• Nakae Takashi

  Biochemical Research Laboratory Ezaki Glico Co. Ltd.

• Ando M

  Graduate School Kyushu Univ. Fukuoka Jpn

• Nishimura T

  Biochemical Research Laboratory Ezaki Glico Co. Ltd.

• Otake Noboru

  Department Of Biosciences Teikyo University

• Nishimura Toshio

  Department Of Pathology Kansai Medical University

• Nishimura Toshio

  Department Of Communication Engineering Osaka University

• Kataoka Takao

  Department Of Applied Biology Kyoto Institute Of Technology

• Nishimura Toshio

  Department Of Biosciences School Of Science And Engineering Teikyo University

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