Prodigiosin 25-C and Metacycloprodigiosin Suppress the Bone Resorption by Osteoclasts

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概要

• 論文の詳細を見る

• Prodigiosin 25-C and metacycloprodigiosin were found to suppress PTH-stimulated pit formation by cultured osteoclasts on bone slices. They also inhibited the acidification of vacuolar organelles in intact osteoclastic cells. Since the acidic pH in these organelles is generated by the action of proton-pumping ATPases of the organelle, these results indicate that the proton-pumping activity of V-ATPase in osteoclastic cells is essential in bone resorption and that the inhibition of the acidification of vacuolar organelles by prodigiosins results in suppression of PTH-stimulated bone resorption.

• 社団法人日本農芸化学会の論文
• 1997-02-23

著者

• KATAOKA Takao

  Department of Bioengineering, Tokyo Institute of Technology

• NAGAI Kazuo

  Department of Bioengineering, Tokyo Institute of Technology

• Kataoka T

  Tokyo Inst. Technol. Yokohama Jpn

• Kataoka Takao

  東京工業大学

• Kudo T

  Inst. Physical And Chemical Res. (riken) Saitama Jpn

• Ohba Yasuo

  Department Of Orthodontics School Of Dentistry The University Of Tokushima

• Ohba Yasuo

  Department Of Electrical Engineering Nagoya University:(present Address) Matsushita Electric Industr

• SUMITANI Koji

  Department of Orthodontics, School of Dentistry, The University of Tokushima

• Nagai K

  Yamanouchi Pharmaceutical Co. Ltd. Tokyo Jpn

• Nagai Kazuo

  Department Of Applied Biological Chemistry Chubu University

• Nagai K

  Chubu Univ. Aichi Jpn

• WOO Je-Tae

  Department of Bioengineering, Tokyo Institute of Technology

• Kataoka Takao

  Department Of Bioengineering Tokyo Institute Of Technology

• Woo Je-tae

  Dep. Of Biological Chemistry Chubu Univ.

• Woo J‐t

  Chubu Univ. Aichi Jpn

• Woo Je-tae

  Department Of Applied Biological Science Tokyo Noko University

• Woo Je-tae

  Sagami Chemical Research Center

• Woo Je-tae

  Department Of Bioengineering Tokyo Institute Of Technology

• TAGAMI Kahori

  Department of Orthodontics, School of Dentistry, The University of Tokushima

• Tagami Kahori

  Department Of Orthodontics School Of Dentistry The University Of Tokushima

• Sumitani Koji

  Department Of Orthodontics School Of Dentistry The University Of Tokushima

• Kataoka Takao

  Department Of Applied Biology Kyoto Institute Of Technology

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