Honokiol Inhibits Osteoclast Differentiation and Function in Vitro

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概要

• 論文の詳細を見る

• Honokiol, a neolignan, is a physiologically active component of kouboku (Magnolia obovata), a herb used in traditional Chinese medicine. This study investigated the effects of honokiol on the differentiation and function of osteoclasts induced by receptor activator of nuclear factor-κB ligand (RANKL). Honokiol markedly inhibited RANKL-induced tartrate-resistant acid phosphatase (TRAP) activity and the formation of TRAP-positive multinucleated cells in both bone marrow-derived monocytes and RAW264 cells. In experiments to elucidate its mechanism of action, honokiol was found to suppress RANKL-induced phosphorylation of p38 mitogen-activated protein kinase (MAPK), extracellular signal-regulated kinase (ERK), and c-Jun N-terminal kinase (JNK). The RANKL-induced expressions of c-Fos and nuclear factor of activated T cells-c1 (NFATc1), which are crucial transcriptional factors for osteoclastogenesis, were also reduced by treatment with honokiol. Furthermore, honokiol induced disruption of the actin rings in mature osteoclasts (mOCs) without affecting the cell viability and suppressed osteoclastic pit formation on dentin slices. Taken together, these results suggest that honokiol inhibits osteoclast differentiation by suppressing the activation of MAPKs (p38 MAPK, ERK and JNK), decreasing the expressions of c-Fos and NFATc1, and attenuates bone resorption by disrupting the actin rings in mOCs. Therefore, honokiol could prove useful for the treatment of bone diseases associated with excessive bone resorption.

• 公益社団法人　日本薬学会の論文

著者

• NAGAI Kazuo

  Department of Bioengineering, Tokyo Institute of Technology

• Yagasaki Kazumi

  Department Of Applied Biological Science Tokyo Noko University

• HASEGAWA Shin-ichi

  Department of Chemistry and Chemical Engineering, Faculty of Engineering, Niigata University

• Nagai Kazuo

  Department Of Applied Biological Chemistry Chubu University

• Yonezawa Takayuki

  Research Institute for Biological Functions, Chubu University

• WOO Je-Tae

  Department of Bioengineering, Tokyo Institute of Technology

• CHA Byung-Yoon

  Research Institute for Biological Functions, Chubu University

• TERUYA Toshiaki

  Research Institute for Biological Functions, Chubu University

• Yagasaki Kazumi

  Department Of Agricultural Chemistry Faculty Of Agriculture Tokyo Noko University

• Woo Je-tae

  Department Of Applied Biological Science Tokyo Noko University

• TAKAMI Masamichi

  Department of Biochemistry, School of Dentistry, Showa University

• Ahn Jae-Yong

  Department of Biological Chemistry, Chubu University

• Yonezawa Takayuki

  Research Institute For Biological Functions Chubu University

• Hasegawa Shin-ichi

  Department Of Biological Science And Technology Faculty Of Engineering The University Of Tokushima

• Takami Masamichi

  Department Of Biochemistry School Of Dentistry Showa University

• Cha Byung-yoon

  Research Institute For Biological Functions Chubu University

• Teruya Toshiaki

  Research Institute For Biological Functions Chubu University

• Yagasaki Kazumi

  Department of Nutriproteomics, Graduate School of Medicine, The University of Tokyo

• Hasegawa Shin-ichi

  Department of Biological Chemistry, Chubu University

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