Effect of Apple Polyphenol Extract on Hepatoma Proliferation and Invasion in Culture and on Tumor Growth, Metastasis, and Abnormal Lipoprotein Profiles in Hepatoma-Bearing Rats
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概要
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The effect of apple polyphenol extract (APE) on the proliferation and invasion of a rat ascites hepatoma cell line of AH109A was examined in vitro. APE suppressed both the hepatoma proliferation and invasion in a dose-dependent manner up to 200 μg/ml. Serum obtained from rats orally given APE also inhibited hepatoma proliferation and invasion when added to the culture medium. Subsequently, the effect of dietary APE on growth and the metastasis of AH109A hepatomas were investigated in vivo. APE reduced the growth and metastasis of solid hepatomas and significantly suppressed the serum lipid peroxide level in rats transplanted with AH109A. APE also suppressed the serum very-low-density lipoprotein + low-density lipoprotein (VLDL + LDL)-cholesterol level. These in vitro and in vivo findings suggest that APE has anti-hepatoma activities.
- 社団法人 日本農芸化学会の論文
- 2007-11-23
著者
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Miura Yutaka
Department of Cardiovascular Medicine, Tohoku University Graduate School of Medicine
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Yagasaki Kazumi
Department Of Applied Biological Science Tokyo Noko University
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Miura Yutaka
Department Of Agricultural Chemistry Faculty Of Agriculture The University Of Tokyo
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Yagasaki Kazumi
Department Of Agricultural Chemistry Faculty Of Agriculture Tokyo Noko University
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MIURA Daiki
Department of Applied Biological Science, Tokyo Noko University
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Miura Daiki
Department Of Applied Biological Science Tokyo Noko University
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