Identification of New Prognostic Factors of Pulmonary Hypertension
スポンサーリンク
概要
- 論文の詳細を見る
Background: Pulmonary hypertension (PH) still remains a serious disease, for which the plasma level of brain natriuretic peptide (BNP) and hemodynamic variables (eg, cardiac index: CI) are established prognostic factors. The aim of the present study was to identify new additional prognostic factors of the disorder to improve the management of PH. Methods and Results: The study cohort comprised 136 consecutive PH patients admitted to hospital from 1974 to 2008, all of whom were closely followed every 6-12 months. During the follow-up period of 53.5±4.5 [SEM] months, 47 patients died of cardiopulmonary causes. The patients who were initially treated with monotherapy showed improved pulmonary hemodynamics when subsequently treated with combination therapy. Multivariate analysis showed that BNP and CI were significant and independent prognostic factors in all PH patients. However, in PH patients with low CI at diagnosis, only CI improvement by PH therapy was a significant and independent prognostic factor. Indeed, the patients with low CI at diagnosis (CI <2.5) followed by subsequent normalization in response to therapy (CI ≥2.5) showed a significantly better survival compared with those without such normalization. Conclusions: CI normalization in response to treatment is an independent new prognostic factor of PH in patients with low CI at diagnosis, suggesting the importance of intensive therapy to achieve CI normalization. (Circ J 2010; 74: 1965 - 1971)
- 2010-08-25
著者
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Fukumoto Yoshihiro
Department Of Cardiovascular Medicine Tohoku University Graduate School Of Medicine
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下川 宏明
東北大学循環器内科学
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Sakamoto Kazuhiko
Division Of Internal Medicine Saito Hospital
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Shimokawa Hiroaki
Department of Cardiology, Tohoku University School of Medicine
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Shimamoto K
Department Of Internal Medicine Ii Sapporo Medical University
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Nakamura M
Department Of Cardiology Mie University Graduate School Of Medicine
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Sato Hitoshi
Sports Clinic Juntendo University Hospital
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Shimada Kazuyuki
山口大学 医学系研究科器官病態内科学
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Shimada Kazuyuki
大阪府立病院機構大阪府立急性期総合医療センター
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Shirato Kunio
山口大学 医学系研究科器官病態内科学
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Shimamoto Kazuaki
札幌医科大学 医学部内科学第二
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Shimamoto Kazuaki
()
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Shimokawa Hiroaki
Department Of Cardiovascular Medicine Tohoku University Graduate School Of Medicine
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Shirato K
Department Of Internal Medicine Ii Sapporo Medical University
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Kawano Satoru
Medicine Of Cardiovascular Pathophysiology Graduate School Of Comprehensive Human Science University
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TAWARA Shunsuke
Department of Cardiovascular Medicine, Tohoku University Graduate School of Medicine
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NAKANO Makoto
Department of Cardiovascular Medicine, Tohoku University Graduate School of Medicine
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Sugimura Koichiro
Department of Cardiovascular Medicine, Tohoku University Graduate School of Medicine
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Oikawa Minako
Department of Cardiovascular Medicine, Tohoku University Graduate School of Medicine
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Satoh Kimio
Department of Cardiovascular Medicine, Tohoku University Graduate School of Medicine
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Miura Yutaka
Department of Cardiovascular Medicine, Tohoku University Graduate School of Medicine
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TATEBE Shunsuke
Department of Cardiovascular Medicine, Tohoku University Graduate School of Medicine
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MIYAMICHI Saori
Department of Cardiovascular Medicine, Tohoku University Graduate School of Medicine
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Sugimoto Ken
東北大学 臨床薬学
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Sugimoto Ken
Department Of Geriatric Medicine Osaka University Graduate School Of Medicine
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Shimoda Kazuya
Division Of Cardiovascular Medicine Jichi Medical University School Of Medicine
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Oikawa Minako
Department Of Cardiovascular Medicine Tohoku University Graduate School Of Medicine
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Oikawa Minako
Department Of Cardiovascular Medicine Tohoku University
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Shirato Kunio
Department Of Internal Medicine Ii Sapporo Medical University
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Sugimura Kohichiro
東北大学 医学系研究科循環器病態学分野
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Sugimura Koichiro
東北大学 循環器内科
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SHIMAMOTO Kazuaki
Committee for Epidemiology and Clinical Management of Atherosclerosis
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Shirato Kunio
東北大学 第1内科
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Kawano Satoru
筑波大学臨床医学系 循環器内科
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Oikawa Minako
Department Of Cardiovascular Medicine Tohoku University Hospital
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Shimamoto Kazuaki
帝京大学 医学部内科
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Shimokawa H
Department Of Cardiovascular Medicine Tohoku University Graduate School Of Medicine
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Shioji Keisuke
国立循環器病センター 疫学部
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Shioji Keisuke
Department Of Epidemiology National Cardiovascular Center
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Shimada K
Division Of Cardiovascular Medicine Department Of Medicine Jichi Medical University
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Simada Kazuyuki
南郷村国民健康保険病院
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Sugimura Kohichiro
Department Of Cardiovascular Medicine Tohoku University Graduate School Of Medicine
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Shimada Kazuyuki
Division Of Cardiovascular Medicine Jichi Medical School
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Kawano Satoru
Division Of Cardiology Institute Of Clinical Medicine University Of Tsukuba
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Miura Yutaka
Department Of Cardiovascular Medicine Tohoku University Graduate School Of Medicine
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Miura Yutaka
Department Of Agricultural Chemistry Faculty Of Agriculture The University Of Tokyo
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Shimamoto Kazuaki
The 2nd Department Of Internal Medicine Sapporo Medical College
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Shimamoto Kazuaki
Second Department Of Internal Medicine Sapporo Medical College
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Nakagawa Makoto
Department Of Cardiovascular Medicine Tohoku University Graduate School Of Medicine
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Obinata Masuo
Department Of Cardiovascular Medicine Tohoku University Graduate School Of Medicine
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Tawara Shunsuke
Department Of Cardiovascular Medicine Tohoku University Graduate School Of Medicine
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Oikawa Masayoshi
First Department Of Internal Medicine Fukushima Medical University
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Shimamoto Kazuaki
2nd Department Of Internal Medicine Sapporo Medical University
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Shimamoto Kazuaki
The 2nd Department Of Internal Medicine Sapporo Medical University School Of Medicine
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Nakano Makoto
Department Of Cardiovascular Medicine Tohoku University Graduate School Of Medicine
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Sugimura Kouichiro
Department Of Cardiovascular Medicine Tohoku University Graduated School Of Medicine
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Shimada Kazuyuki
Division Of Cardiology Jichi Medical School
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Shimokawa Hiroaki
Department Of Cardiology Tohoku University School Of Medicine
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Shimokawa Hiroaki
Kyushu University Graduate School Of Medical Sciences
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Satoh Kiichi
Department Of Internal Medicine Division Of Gastroenterology Jichi Medical University
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Shimamoto Kazuaki
Second Department Of Internal Medicine (cardiovascular Medicine) Sapporo Medical University School O
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Sugano K
Department Of Internal Medicine Division Of Gastroenterology Jichi Medical University
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Kawano Satoru
Cardiovascular Division Institute Of Clinical Medicine Graduate School Of Comprehensive Human Scienc
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Miyamichi Saori
Department Of Cardiovascular Medicine Tohoku University Graduate School Of Medicine
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Shimamoto Kazuaki
The Seceond Department Of Internal Medicine Sapporo Medical University School Of Medicine
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Shimada Kazuyuki
The Departments Of Cardiology Echi Medical School
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Satoh Kimio
Department Of Cardiovascular Medicine Tohoku University Graduate School Of Medicine
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Simada Kazuyuki
Division Of Cardiovascular Medicine Department Of Medicine Jichi Medical School
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Nakamura Masayuki
1st Department Of Internal Medicine Faculty Of Medicine Mie University
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Shimokawa Hiroaki
Department Of Cardiovascular Medicine Kyushu University Graduate School Of Medical Science
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Fukumoto Yoshihiro
Department Of Cardiovascular Medicine Kyushu University Graduate School Of Medical Sciences
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Suzuka Hiroshi
Department Of Cardiovascular Medicine Tohoku University Graduate School Of Medicine
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Shimamoto Kazuaki
The Second Department Of Internal Medicine Sapporo Medical College
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Kawano Satoru
Cardiovascular Division Institute Of Clinical Medicine Graduate School Of Comprehensive Human Scienc
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Shimokawa Hiroaki
From Reseach Institute Of Angiocardiology And Cardiovascular Clinic Faculty Of Medicine Kyushu Unive
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Sato Kouichi
Department Of Cardiovascular Medicine Tohoku University Graduate School Of Medicine
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Ninomiya Mototsugu
Department Of Cardiovascular Medicine Tohoku University Graduate School Of Medicine
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Kawano Satoru
Medicine Of Cardiovascular Pathophysiology Graduate School Of Comprehensive Human Science University Of Tsukuba
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Fukumoto Yoshihiro
Department of Cardiovascular Medicine and Department of Evidence-based Cardiovascular Medicine, Tohoku University Graduate School of Medicine
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