Prognostic Effects of Calcium Channel Blockers in Patients With Vasospastic Angina : A Meta-Analysis
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概要
- 論文の詳細を見る
Background: Although calcium channel blockers (CCB) are highly effective for suppression of vasospastic angina (VSA) attacks, their prognostic effects in VSA patients remain to be examined in a large number of patients. Methods and Results: Databases for related papers were searched and then a meta-analysis regarding the effects of CCB on major adverse cardiovascular events (MACE) in Japanese VSA patients with the 4 previous studies was performed. A total of 1,997 patients with positive coronary spasm provocation tests were evaluated. They were treated with either alone or combination of benidipine (n=320), amlodipine (n=308), nifedipine (n=182) or diltiazem (n=960). MACE were observed in 143 patients (cardiac death: 36, myocardial infarction: 51, heart failure: 26, stroke: 65, and aortic aneurysm: 11). The hazard ratio for the occurrence of MACE was significantly lower in patients treated with benidipine than in those with diltiazem. There was no significant difference in the clinical characteristics affecting the occurrence of MACE among the 4 CCB groups. Furthermore, the hazard ratio for the occurrence of MACE was significantly lower in those treated with benidipine, even after correction for patient characteristics that could have affected the occurrence of MACE (hazard ratio 0.41, P=0.016). Conclusions: These results suggest that among the 4 major CCB that effectively suppress VSA attacks in general, benidipine showed significantly more beneficial prognostic effects than others. (Circ J 2010; 74: 1943 - 1950)
- 社団法人 日本循環器学会の論文
- 2010-08-25
著者
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Fukumoto Yoshihiro
Department Of Cardiovascular Medicine Tohoku University Graduate School Of Medicine
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Shimokawa Hiroaki
Department of Cardiology, Tohoku University School of Medicine
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Yasuda Satoshi
Department Of Cardiovascular Medicine Tohoku University Graduate School Of Medicine
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Inoue Yukiko
Department Of Cardiovascular Diseases Fukuoka University Chikushi Hospital
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NISHIGAKI Kazuhiko
Second Department of Internal Medicine, Gifu University Graduate School of Medicine
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MINATOGUCHI Shinya
Second Department of Internal Medicine, Gifu University Graduate School of Medicine
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Sato Hitoshi
Sports Clinic Juntendo University Hospital
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Urata Hidenori
Department Of Cardiovascular Diseases Fukuoka University Chikushi Hospital
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Shimokawa Hiroaki
Department Of Cardiovascular Medicine Tohoku University Graduate School Of Medicine
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Shimokawa H
Department Of Cardiovascular Medicine Tohoku University Graduate School Of Medicine
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Sueda Shozo
Department Of Cardiology Saiseikai Saijo Hospital
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Sueda Shozo
Department Of Cardiology Ehime Prefectural Niihama Hospital
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Yamanouchi Yoshio
Department Of Cardiology Fukuoka University School Of Medicine
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Nishigaki Kazuhiko
Second Department Of Internal Medicine Gifu University Graduate School Of Medicine
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Yamanouchi Yoshio
Department Of Cardiovascular Diseases Fukuoka University Chikushi Hospital
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Yasuda Satoshi
Department Of Biological Chemistry Faculty Of Pharmaceutical Sciences Nagoya City University
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Shimokawa Hiroaki
Department Of Cardiology Tohoku University School Of Medicine
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Urata Hidenori
Department Of Cardiology Fukuoka University School Medicine
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Urata Hidenori
Department Of Cardiology Fukuoka University School Of Medicine Fukuoka University
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Shimokawa Hiroaki
Department Of Cardiovascular Medicine Kyusyu University Graduate School Of Medicine
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Minatoguchi Shinya
Second Department Of Internal Medicine Gifu University Graduate School Of Medicine
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Nishigaki Kazuhiko
Second Department Of Internal Medicine Gifu University
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Urata Hidenori
Department Of Cardiology Fukuoka University School Of Medicine
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Inoue Yukiko
Department Of Biochemistry And Cellular Biology National Institute Of Neuroscience National Center O
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Fukumoto Yoshihiro
Department Of Cardiovascular Medicine Kyushu University Graduate School Of Medical Sciences
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Suzuka Hiroshi
Department Of Cardiovascular Medicine Tohoku University Graduate School Of Medicine
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Yasuda Satoshi
Department Of Biochemistry Sapporo Medical University School Of Medicine
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Yamanouchi Yoshio
Department Of 2nd Internal Medicine Fukuoka University
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Shimokawa Hiroaki
Departments Of Cardiovascular Medicine And Evidence-based Cardiovascular Medicine Tohoku University
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Fukumoto Yoshihiro
Department of Cardiovascular Medicine and Department of Evidence-based Cardiovascular Medicine, Tohoku University Graduate School of Medicine
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