Effects of Dexamethasone on the Production of Insulin-like Growth Factor-I and Insulin-like Growth Factor Binding Proteins in Primary Cultures of Rat Hepatocytes
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概要
- 論文の詳細を見る
The effects of dexamethasone (Dex) on insulin-like growth factor (IGF)-I and IGF binding protein (IGFBP)-1 production were investigated in primary cultures of rat hepatocytes. Dex enhanced the secretion of IGFBP-1 as measured by ligand blot analysis but did not show any prominent effect on immunoreactive IGF-I secretion. EC_<50> of Dex on IGFBP-1 secretion was calculated to be 3×10^<-8>M. The content of IGFBP-1 mRNA in the cells increased greatly in the presence of Dex but the IGF-I mRNA content did not change significantly under the same conditions. Insulin showed the opposite effect of Dex by decreasing the production of IGFBP-1 and the cellular content of IGFBP-1 mRNA. This effect of insulin was observed also with Dex in the medium. These results show that the gene expression of IGF-I and IGFBP-1 is differently regulated by glucocorticoids and insulin in primary cultures of rat hepatocytes. The results most possibly explain the in vivo effects of glucocorticoids and insulin in regulation of IGF-I and IGFBP-1 production by liver.
- 社団法人日本農芸化学会の論文
- 1992-09-23
著者
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Miura Yutaka
Department of Cardiovascular Medicine, Tohoku University Graduate School of Medicine
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HIGASHI Yusuke
Department of Mechanical Engineering, Kyushu Institute of Technology
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Miura Y
Department Of Applied Biological Science Tokyo Noko University
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Miura Yutaka
Applied Bioresearch Center Kirin Brewry Co. Ltd.
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Miura Yutaka
Department Of Agricultural Chemistry Faculty Of Agriculture The University Of Tokyo
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Higashi Yusuke
Department Of Agricultural Chemistry Faculty Of Agriculture The Univerisity Of Tokyo
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Kato H
Department Of Agricultural Chemistry The University Of Tokyo
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Kato Hiromichi
Department Of Food Science Ohtsuma University
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NOGUCHI Tadashi
Department of Pediatrics, Faculty of Medicine, Kanazawa University
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Miyamoto Yoshiro
Department Of Biochemical Engineering Faculty Of Computer Science And System Engineering Kyushu Inst
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KATO Hisanori
Department of Agricultural Chemistry, Faculty of Agriculture, The University of Tokyo
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Takahashi S
Akita Res. Inst. Food And Brewing Akita
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Kato H
Otsuma Women's Univ. Tokyo Jpn
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TAKAHASHI SHIN-ICHIRO
Department of Animal Sciences, Graduate School of Agriculture and Life Sciences, The University of T
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Noguchi Tadashi
Department Of Applied Biological Chemistry Graduate School Of Agricultural And Life Sciences The Uni
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Kato H
Department Of Applied Biological Chemistry Graduate School Of Agricultural And Life Sciences The Uni
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Kato Hiroshi
Department Of Applied Biological Chemistry Graduate School Of Agricultural And Life Sciences The Uni
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Takahashi Shin-ichiro
Department Of Animal Sciences Graduate School Of Agriculture And Life Sciences The University Of Tok
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Suzuki Takahito
Biological Laboratory Faculty Of Science Nara Women's University
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Miyamoto Yoko
Laboratory Of Biochemistry Faculty Of Agriculture Kyushu University
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Takahashi Shin-ichiro
Department Of Animal Sciences And Applied Biological Chemistry The University Of Tokyo
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NOGUCHI Tadashi
Department of Agricultural Chemistry, Faculty of Agriculture, The University of Tokyo
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TAKAHASHI Shin-Ichiro
Department of Agricultural Chemistry, Faculty of Agriculture, The University of Tokyo
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