Possible Involvement of Calcium Signaling Pathways in L-Leucine-Stimulated Protein Synthesis in L6 Myotubes
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概要
- 論文の詳細を見る
L-Leucine is known to stimulate protein synthesis in L6 myotubes. In the present study, we examined the possible involvement of calcium signaling pathways in the stimulation of protein synthesis induced by L-leucine in L6 myotubes. After 16 h of treatment with L-leucine-depleted medium, the re-addition of L-leucine for 4 h augmented protein synthesis by about 50% as compared with an L-leucine-depleted control. Ryanodine receptor antagonists almost completely abolished the stimulatory effect of L-leucine, while IP3 receptor antagonists showed partial inhibition when added simultaneously with L-leucine. These results suggest the possibility that calcium signaling pathways are involved in L-leucine-stimulated protein synthesis.
- 社団法人 日本農芸化学会の論文
- 2006-06-23
著者
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Miura Yutaka
Department of Cardiovascular Medicine, Tohoku University Graduate School of Medicine
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Yagasaki Kazumi
Department Of Applied Biological Science Tokyo Noko University
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Miura Yutaka
Department Of Agricultural Chemistry Faculty Of Agriculture The University Of Tokyo
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Yagasaki Kazumi
Department Of Agricultural Chemistry Faculty Of Agriculture Tokyo Noko University
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Miura Yutaka
Department Of Applied Biological Science Tokyo Noko University
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NAKAZAWA Taro
Department of Applied Biological Science, Tokyo Noko University
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Nakazawa Taro
Department Of Applied Biological Science Tokyo Noko University
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