Comparison of the Effects on Lipid Metabolism of Dietary Methionine and Cystine between Hepatoma-Bearing and Normal Rats
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概要
- 論文の詳細を見る
The effects of dietary supplementation with methionine and cystine on lipid metabolism, including the serum lipid concentration, were studied in Donryu rats subcutaneously implanted with an ascites hepatoma cell line (AH109A) for comparison with normal rats. A diet supplemented with 1.2% L-methionine or L-cystine to 20% casein was found to suppress the hepatoma-induced increases in serum triglyceride and total cholesterol concentration. The lipoprotein lipase activity in tissues was enhanced by dietary methionine and cystine, with no change in the mRNA level. Dietary methionine and cystine increased bile acid excretion into the feces with enhanced hepatic cholesterol 7α-hydroxylase activity. Dietary methionine and cystine affected the lipid metabolism differently in normal rats from hepatoma-bearing rats. These results suggest that dietary methionine and cystine each had a hypolipidemic effect against cancer-induced hyperlipidemia, and that the different actions observed in the hepatoma-bearing and normal rats may have been due to a metabolic abnormality caused by the cancer.
- 社団法人 日本農芸化学会の論文
著者
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Miura Yutaka
Department of Cardiovascular Medicine, Tohoku University Graduate School of Medicine
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KAWASAKI Masashi
Department of Applied Biological Science, Tokyo Noko University
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FUNABIKI Ryuhei
Department of Applied Biological Science, Tokyo Noko University
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YAGASAKI Kazumi
Department of Applied Biological Science, Tokyo Noko University
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Funabiki Ryuhei
東京農工大学
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Funabiki Ryuhei
Department Of Applied Biological Science Tokyo Noko University
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Yagasaki Kazumi
Department Of Applied Biological Science Tokyo Noko University
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Kawasaki M
Institute For Materials Research (imr) Tohoku University
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Miura Yutaka
Applied Bioresearch Center Kirin Brewry Co. Ltd.
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Miura Yutaka
Department Of Agricultural Chemistry Faculty Of Agriculture The University Of Tokyo
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Kawasaki Masashi
Department Of Applied Biological Science Tokyo Noko University
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