Anti-Invasive Activity of Niacin and Trigonelline against Cancer Cells

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概要

• 論文の詳細を見る

• The effects of niacin, namely, nicotinic acid and nicotinamide, and trigonelline on the proliferation and invasion of cancer cells were studied using a rat ascites hepatoma cell line of AH109A in culture. Niacin and trigonelline inhibited the invasion of hepatoma cells at concentrations of 2.5–40 μM without affecting proliferation. Hepatoma cells previously cultured with a reactive oxygen species (ROS)-generating system showed increased invasive activity. Niacin and trigonelline suppressed this ROS-potentiated invasive capacity through simultaneous treatment of AH109A cells with the ROS-generating system. The present study indicates for the first time the anti-invasive activities of niacin and trigonelline against cancer cells.

• 社団法人 日本農芸化学会の論文
• 2005-03-23

著者

• Miura Yutaka

  Department of Cardiovascular Medicine, Tohoku University Graduate School of Medicine

• YAGASAKI Kazumi

  Department of Applied Biological Science, Tokyo Noko University

• Yagasaki Kazumi

  Department Of Applied Biological Science Tokyo Noko University

• Yagasaki Kazumi

  東京農工大学

• Miura Yutaka

  Applied Bioresearch Center Kirin Brewry Co. Ltd.

• Miura Yutaka

  Department Of Agricultural Chemistry Faculty Of Agriculture The University Of Tokyo

• Yagasaki K

  Department Of Applied Biological Science Tokyo Noko University

• Yagasaki Kazumi

  Department Of Agricultural Chemistry Faculty Of Agriculture Tokyo Noko University

• Miura Yutaka

  Department Of Applied Biological Science Tokyo Noko University

• HIRAKAWA Nobuhiro

  Department of Applied Biological Science, Tokyo Noko University

• OKAUCHI Rieko

  Department of Applied Biological Science, Tokyo Noko University

• Okauchi Rieko

  Department Of Applied Biological Science Tokyo Noko University

• Miura Y

  Tokyo Noko Univ. Tokyo Jpn

• Miura Yutaka

  Dep. Of Applied Biological Sci. Tokyo Noko Univ.

• Hirakawa Nobuhiro

  Department Of Applied Biological Science Tokyo Noko University

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