Arginine as an Exacerbating Factor for Glomerulonephritis in Rats Fed a Methionine-threonine-supplemented Low Casein Diet
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概要
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We previously demonstrated that a methionine-threonine-supplemented low (8.5%) casein diet (8.5CMT) reduced symptoms such as proteinuria in nephritic rats without severe protein malnutrition. In this study, we examined whether or not L-arginine supplementation to 8.5CMT would exacerbate proteinuria and other symptoms in nephritic rats. Male Wistar rats with glomerulonephritis induced by a single intravenous injection of nephrotoxic serum were fed either a 20% casein diet (control), 8.5% casein diet, 8.5CMT, or L-arginine-supplemented 8.5CMT (8.5CMTA) for 16 days. The 8.5CMTA, as compared with the 8.5CMT, aggravated proteinuria and glomerulonephritis. Administration of L-N^G-nitroarginine methyl ester, an inhibitor of nitric oxide synthase, to 8.5CMTA-fed nephritic rats by drinking water for 14 days canceled the adverse effect of L-arginine on proteinuria and histopathological damage in glomeruli. These results suggest that the supplementation of L-arginine makes exacerbation via nitric oxide production in glomerulonephritis.
- 2001-05-23
著者
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Miura Yutaka
Department of Cardiovascular Medicine, Tohoku University Graduate School of Medicine
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Yagasaki Kazumi
Department Of Applied Biological Science Tokyo Noko University
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Miura Yutaka
Department Of Agricultural Chemistry Faculty Of Agriculture The University Of Tokyo
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Arai K
Tissue Physiology Tokyo Noko University
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NIHEI Takeshi
Department of Physics, Faculty of Science and Technology, Nihon University
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Yagasaki Kazumi
Department Of Agricultural Chemistry Faculty Of Agriculture Tokyo Noko University
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Yagasaki Kazumi
Departments Of Applied Biological Science Tokyo Noko University
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Arai Katsuhiko
Tissue Physiology Tokyo Noko University
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Nihei Takeshi
Departments Of Applied Biological Science Tokyo Noko University
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Nihei Takeshi
Department Of Physics Faculty Of Science And Technology Nihon University
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Miura Yutaka
Departments Of Applied Biological Science Tokyo Noko University
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