Reaction Mechanism of a New Glycosyltrehalose-producing Enzyme Isolated from the Hyperthermophilic Archaeum, Sulfolobus solfataricus KM1

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概要

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• An amylolytic activity, which converts soluble starch to α,α-trehalose (trehalose), was found in the cell homogenate of the hyperthermophilic, acidophilic archaeum Sulfolobus solfataricus KM1. Two enzymes, a glycosyltransferase and an amylase, which are essential for this activity, were purified to homogeneity. A glycosyltransferase catalyzed the conversion of maltooligosaccharides to glycosyltrehaloses. Based on a detailed analysis of the reaction products, kinetic parameters, and an experiment using ^3H-labeled substrates, it was verified that glycosyltransferase transferred an oligomer segment of maltooligosaccharide to the C1-OH position of glucose, located at the reducing end of the maltooligosaccharide, to produce a glycosyltrehalose having an α-1,1 linkage. The reaction appears to be intramolecular. Nine strains of the Sulfolobaceae family were found to have glycosyltransfrases.

• 社団法人日本農芸化学会の論文
• 1996-05-23

著者

• SHINDO Kazutoshi

  Pharmaceutical Research Laboratory, Kirin Brewery Co. Ltd.

• IWAMATSU Akihiro

  Central Lab. Key Tech., Kirin Brewery Co.

• Miura Y

  Department Of Applied Biological Science Tokyo Noko University

• Miura Yutaka

  Applied Bioresearch Center Kirin Brewry Co. Ltd.

• Miura Yutaka

  Department Of Agricultural Chemistry Faculty Of Agriculture The University Of Tokyo

• Kato M

  Nagoya Univ. Aichi Jpn

• Miyamoto Yoshiro

  Department Of Biochemical Engineering Faculty Of Computer Science And System Engineering Kyushu Inst

• Iwamatsu A

  Kirin Brewery Co. Ltd. Kanagawa Jpn

• Iwamatsu A

  Kirin Brewery Co. Ltd. Yokohama Jpn

• Iwamatsu Akihiro

  Central Lab. Key Tech. Kirin Brewery Co.

• KOBAYASHI Kazuo

  Applied Bioresearch Center, Kirin Brewery Co., Ltd.

• KATO Masaru

  Applied Bioresearch Center, Kirin Brewery Co., Ltd.

• KETTOKU Masako

  Applied Bioresearch Center, Kirin Brewery Co., Ltd.

• Kobayashi K

  Inst. Physical And Chemical Res.(riken) Saitama Jpn

• Shindo Kazutoshi

  Pharmaceutical Research Laboratories Kirin Brewery Co. Ltd.

• Kato M

  Dep. Of Biological Mechanisms And Functions Graduate School Of Bioagricultural Sciences Nagoya Univ.

• Kobayashi K

  Department Of Life Science (sports Sciences) The University Of Tokyo

• Shindo K

  Department Of Food And Nutrition Japan Women's University

• Miura Y

  Tokyo Noko Univ. Tokyo Jpn

• Miura Yutaka

  Dep. Of Applied Biological Sci. Tokyo Noko Univ.

• Shindo Kazutoshi

  Japan Women's University

• Miyamoto Yoko

  Laboratory Of Biochemistry Faculty Of Agriculture Kyushu University

• IWAMATSU Akihiro

  Central Lab. Key Tech. , Kirin Brewery Co.

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