Identification of Protein Kinase B (PKB) as a Phosphatidylinositol 3,4,5-Trisphosphate Binding Protein in Dictyostelium discoideum

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概要

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• We have searched for phosphatidylinositol (PI)-3,4,5-trisphosphate (PIP_3) binding proteins in Dictyostelium discoideum using beads bearing a PIP_3 analogue, PIP_3-APB. One of the binding proteins with a molecular mass of 55 kDa was purified and its amino acid sequence was partially amalyzed. Database searches showed that the analyzed sequence was identical to that of protein kinase B (PKB) of D. discoideum. The specific activity of D. discoideum PKB, when expressed together with constitutively active PI-3 kinase in mammalian cells, was elevated by about three-fold, suggesting that PKB could also act downstream of PI-3 kinase in Dictyostelium cells.

• 社団法人日本農芸化学会の論文
• 1999-02-23

著者

• ADACHI Hiroyuki

  Department of Biotechnology, University of Tokyo

• IWAMATSU Akihiro

  Central Lab. Key Tech., Kirin Brewery Co.

• Konishi Hiroaki

  Biosignal Research Center Kobe University

• KIKKAWA Ushio

  Biosignal Research Center, Kobe University

• TANAKA Kenichi

  Laboratory of Biological Chemistry, Division of Applied Biological Chemistry, Graduate School of Agr

• OHKAWA Katsuya

  Central Laboratories for Key Technology, Kirin Brewery Co. Ltd.

• SHIRAI Toshiyuki

  Laboratory of Biological Chemistry, Division of Applied Biological Chemistry, Graduate School of Agr

• NAGATA Satoshi

  Laboratory of Biological Chemistry, Division of Applied Biological Chemistry, Graduate School of Agr

• FUKUI Yasuhisa

  Laboratory of Biological Chemistry, Division of Applied Biological Chemistry, Graduate School of Agr

• Iwamatsu Akihiro

  Central Laboratories For Key Technology Kirin Brewery Co. Ltd.

• Iwamatsu Akihiro

  Central Lab. Key Tech. Kirin Brewery Co.

• Adachi Hiroyuki

  Department Of Life Sciences Graduate School Of Arts And Sciences University Of Tokyo

• Adachi Hiroyuki

  Department Of Biotechnology Graduate School Of Agricultural And Life Sciences University Of Tokyo

• Fukui Y

  Research Center For Environmental Genomics Kobe University

• Kikkawa U

  Biosignal Research Center

• Kikkawa Ushio

  Biosig.res.center

• Ohkawa K

  Hokkaido Univ. Sapporo Jpn

• Fukui Yasuhisa

  Laboratory Of Biological Chemistry Division Of Applied Biological Chemistry Graduate School Of Agric

• Fukui Yuko

  Institute For Fundamental Research Suntory Ltd. (sunbor)

• Nagata S

  Ntt Docomo Inc. Yokosuka‐shi Jpn

• Nagata Satoshi

  Laboratory Of Biological Chemistry Division Of Applied Biological Chemistry Graduate School Of Agric

• Shirai Toshiyuki

  Laboratory Of Biological Chemistry Division Of Applied Biological Chemistry Graduate School Of Agric

• Tanaka Kenichi

  Laboratory Of Biological Chemistry Division Of Applied Biological Chemistry Graduate School Of Agric

• IWAMATSU Akihiro

  Central Lab. Key Tech. , Kirin Brewery Co.

• Adachi Hiroyuki

  Department of Life Sciences, Graduate School of Arts and Sciences, University of Tokyo

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