Downstream of Phosphatidylinositol-3 Kinase, a Multifunctional Signaling Molecule, and Its Regulation in Cell Responses.

スポンサーリンク

概要

• 論文の詳細を見る

• Phosphatidylinositol (PI)-3 kinase is an enzyme that phosphorylates the D-3 position of PI and its derivatives. It is activated immediately after growth factor or differentiation factor stimulation, suggesting that PI-3 kinase is involved in signal transduction of the stimulation. PI-3 kinase appears to play various important roles including signaling to the nucleus, vesicle transport, and rearrangement of the cytoskeleton since many cell responses which require these events are affected by inhibition or activation of PI-3 kinase. To understand how PI-3 kinase can act in such multiple ways, it is important to identify the factors downstream of PI-3 kinase. In this review, we discuss the factors downstream of PI-3 kinase and the methods used to identify them. Recent studies revealed that some proteins involved in vesicle transport or in rearrangement of the cytoskeleton are regulated by the phospholipids generated by PI-3 kinase, implying the mechanism by which PI-3 kinase regulates these cell responses.

• 社団法人 日本生化学会の論文

著者

• Fukui Yasuhisa

  Laboratory Of Biological Chemistry Division Of Applied Biological Chemistry Graduate School Of Agric

• Ihara Sayoko

  Laboratory Of Biological Chemistry Department Of Applied Biological Chemistry Division Of Agricultur

• Nagata Satoshi

  Laboratory Of Biological Chemistry Division Of Applied Biological Chemistry Graduate School Of Agric

• Fukui Yasuhisa

  Laboratory of Biological Chemistry, Division of Applied Biological Chemistry, Graduate School of Agriculture and Life Science, The University of Tokyo

関連論文

• Identification of Protein Kinase B (PKB) as a Phosphatidylinositol 3,4,5-Trisphosphate Binding Protein in Dictyostelium discoideum
• Identification of Interleukin-6 as a Factor That Induces Neurite Outgrowth by PC12 Cells Primed with NGF^1
• Isolation of Suppressor Mutants of Phosphatidylinositol 3-Phosphate 5-kinase Deficient Cells in Schizosaccharomyces pombe(Microbiology & Fermentation Technology)
• Inportance of Phosphatidylinositol 3-Phosphate in Sporulation of Schizosaccharomyces pombe(Biochemistry & Molecular Biology)
• Downstream of Phosphatidylinositol-3 Kinase,a Multifunctional Signaling Molecule,and Its Regulation in Cell Reseponses
• Development of a Direct Competitive Microcystin Immunoassay of Broad Specificity
• Downstream of Phosphatidylinositol-3 Kinase, a Multifunctional Signaling Molecule, and Its Regulation in Cell Responses.

スポンサーリンク