Impact of Physical Activity on Cardiovascular Events in Patients With Chronic Heart Failure:– A Multicenter Prospective Cohort Study –
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概要
- 論文の詳細を見る
Background: We have previously demonstrated that the prevalence of metabolic syndrome in chronic heart failure (CHF) is more than double compared with the general population in Japan. However, the impact of physical activity on cardiovascular events in CHF patients remains to be fully elucidated. Methods and Results: We performed a prospective, nationwide large-scale multicenter study of 9,178 patients with stage A/B/C/D CHF in Japan. We obtained the baseline physical activity data for 7,292 and yearly changes in physical activity data during a 3-year follow-up period for 4,353 patients. We divided the patients into high- and low-exercise groups by using the median value of physical activity in the stage A/B and C/D groups. In both groups, patients who exercised more were characterized by younger age and less advanced stage of CHF. Importantly, the baseline physical activity levels were significantly associated with all-cause death, heart failure (HF) hospitalization and other cardiovascular events (except acute myocardial infarction, stroke, HF hospitalization). Furthermore, the yearly change in physical activity level was also significantly associated with HF hospitalization and other cardiovascular events in both groups. Conclusions: The baseline level of physical activity and its yearly changes are significantly associated with all-cause death and major cardiovascular events in both stage A/B and C/D patients, suggesting that physical activity could be an important therapeutic target to improve the long-term prognosis of CHF patients.
- 一般社団法人 日本循環器学会の論文
著者
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Shimada Kazunori
Department of Cardiovascular Medicine, Juntendo University School of medicine
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Kitakaze Masafumi
Cardiovascular Div. Of Medicine National Cardiovascular Center
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Miura Toshiro
Division Of Cardiology Department Of Medicine And Clinical Science Yamaguchi University Graduate Sch
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Asakura Masanori
Cardiovascular Division Of Internal Medicine National Cardiovascular Center
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Yasuda Satoshi
Cardiovasdular Division of Internal Medicine, National Cardiovascular Center
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Miura Yutaka
Department Of Agricultural Chemistry Faculty Of Agriculture The University Of Tokyo
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Daida Hiroyuki
Department Of Cardiology
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Kadokami Toshiaki
Division Of Cardiology Matsuyama Red Cross Hospital
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Shimokawa Hiroaki
Department Of Cardiology Tohoku University School Of Medicine
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Ando Shin-ichi
Division Of Cardiology Saiseikai Futsukaichi Hospital
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Matsuzaki Masunori
Division Of Cardiology Department Of Medicine And Clinical Science Graduate School Of Medicine Yamag
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Fukumoto Yoshihiro
Department Of Cardiovascular Medicine Kyushu University Graduate School Of Medical Sciences
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Sakata Yasuhiko
Department Of Advanced Medicine Nihon University School Of Medicine
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Miyata Satoshi
Department Of Genome Center Cancer Institute Hospital
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Fukumoto Yoshihiro
Department of Cardiovascular Medicine, Tohoku University Graduate School of Medicine
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SHIMADA Kazunori
Department of Biochemistry, Kumamoto University School of Medicine
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Fukumoto Yoshihiro
Department of Cardiovascular Medicine and Department of Evidence-based Cardiovascular Medicine, Tohoku University Graduate School of Medicine
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SHIMADA Kazunori
Department of Biochemistry, Kumamoto University Medical School
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Ando Shin-ichi
Division of Cardiovascular Medicine, Saiseikai Futsukaichi Hospital
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Kitakaze Masafumi
Cardiovascular Division of Internal Medicine, National Cerebral and Cardiovascular Center
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Miyata Satoshi
Department of Cardiovascular Medicine and Department of Evidence-based Cardiovascular Medicine, Tohoku University Graduate School of Medicine
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Kadokami Toshiaki
Division of Cardiovascular Medicine, Saiseikai Futsukaichi Hospital
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Yasuda Satoshi
Cardiovascular Division of Internal Medicine, National Cerebral and Cardiovascular Center
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