Restoration by Dietary Glutamine of Reduced Tumor Necrosis Factor Production in a Low-Protein-Diet-Fed Rat Model
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概要
- 論文の詳細を見る
Tumor necrosis factor-α (TNF) production by peritoneal macrophages and its dietary modification were investigated by using rats fed on a low-protein diet. The rats were given a 20% casein (control) diet or a 3% casein diet for 21 days, and TNF production was measured in activated macrophages of these animals. TNF production was significantly lower in macrophages from rats fed on the low-protein diet than that in macrophages from rats fed on the control diet. Oral administration of a cabbage extract, a known modulator of TNF production, to the low-protein-diet-fed rats significantly enhanced TNF production by macrophages. Glutamine supplementation to the low-protein diet significantly enhanced TNF production as well as TNF mRNA expression. These results indicate that the 3%-casein-diet-fed rat would be useful as a model for reduced TNF production in protein malnutrition. These results also suggest that glutamine administration restored the reduced TNF production associated with protein malnutrition.
- 社団法人 日本農芸化学会の論文
- 2007-02-23
著者
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Miura Yutaka
Department of Cardiovascular Medicine, Tohoku University Graduate School of Medicine
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YAGASAKI Kazumi
Department of Applied Biological Science, Tokyo Noko University
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KOMATSU Wataru
Department of Applied Biological Science, Tokyo Noko University
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Mawatari Kazunori
Amino Acid Department, Ajinomoto Co., Inc.
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Yagasaki Kazumi
Department Of Applied Biological Science Tokyo Noko University
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Yagasaki Kazumi
東京農工大学
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Miura Y
Department Of Applied Biological Science Tokyo Noko University
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Miura Yutaka
Applied Bioresearch Center Kirin Brewry Co. Ltd.
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Miura Yutaka
Department Of Agricultural Chemistry Faculty Of Agriculture The University Of Tokyo
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Komatsu W
Department Of Applied Biological Science Tokyo Noko University:(present Office)department Of Hygiene
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Yagasaki K
Department Of Applied Biological Science Tokyo Noko University
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Miyamoto Yoshiro
Department Of Biochemical Engineering Faculty Of Computer Science And System Engineering Kyushu Inst
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Kaneko Masaharu
Department Of Applied Biological Science Tokyo Noko University
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Yagasaki Kazumi
Department Of Agricultural Chemistry Faculty Of Agriculture Tokyo Noko University
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Miura Y
Tokyo Noko Univ. Tokyo Jpn
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Miura Yutaka
Dep. Of Applied Biological Sci. Tokyo Noko Univ.
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Miyamoto Yoko
Laboratory Of Biochemistry Faculty Of Agriculture Kyushu University
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