Effects of Dietary Methionine and Cystine on Endogenous Hypercholesterolemia in Hypothyroid Rats(Food & Nutrition)
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概要
- 論文の詳細を見る
The effects on cholesterolemia of dietary additions (1.2%) of methionine and cystine to a 20% casein diet were studied in both euthyroid and thiouracil-induced hypothyroid rats. The hypothyroid rats lapsed into endogenous hypercholesterolemia, which was due to an increase in the very-low-density lipoprotein plus low-density lipoprotein-cholesterol [(VLDL+LDL)-Ch] concentration with no change in the high-density lipoprotein-cholesterol (HDL-Ch) concentration. These lipoprotein changes in hypothyroid rats resulted in a marked (5-fold) increase in the atherogenic index [AI, (VLDL-LDL)-Ch/HDL-Ch] when compared to that of elutyroid rats. Methionine reduced the hypercholesterolemia in the hypothyroid state by suppressing the elevation in (VLDL+LDL)-Ch with no significant reduction in HDL-Ch, resulting in a notable fall of AI, while methionine showed no significant effect on cholesterolemia and AI in the euthyroid state. Cystine induced hypercholesterolemia due to a significant elevation of HDL-Ch in the euthyroid state, but the amino acid showed no significant effect on cholesterolemia and hence AI in the hypothyroid state. These results suggest that methionine overcomes changes in the parameters involved in Ch biodynamics that cause hypercholesterolemia in the hypothyroid state, whereas cystine counterbalances the parameter changes and results in diminution of its hypercholesterolemic effect in the hypothyroid state.
- 社団法人日本農芸化学会の論文
- 1986-11-23
著者
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Funabiki Ryuhei
Department Of Applied Biological Science Tokyo Noko University
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Funabiki Ryuhei
Department Of Agricultural Chemistry Faculty Of Agriculture Tokyo Noko University
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Yagasaki Kazumi
Department Of Applied Biological Science Tokyo Noko University
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Aoki T
Shizuoka Univ. Shizuoka‐shi Jpn
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Yagasaki Kazumi
Department Of Agricultural Chemistry Faculty Of Agriculture Tokyo Noko University
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Yagasaki Kazumi
Department Of Agricultural Chemistry Faculty Of Agriculture Tokyo University Of Agriculture And Tech
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Aoki Toru
Department Of Agricultural Chemistry Faculty Of Agriculture Tokyo University Of Agriculture And Tech
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MACHIDA Michie
Department of Agricultural Chemistry, Faculty of Agriculture, Tokyo University of Agriculture and Te
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Funabiki Ryuhei
Department Of Agricultural Chemistry Faculty Of Agriculture Tokyo University Of Agriculture And Tech
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Machida M
Univ. Ryukyus Okinwa Jpn
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