Effect of Dietary Soy Protein on Tumor Necrosis Factor Productivity in Macrophages from Nephritic and Hepatoma-Bearing Rats

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概要

• 論文の詳細を見る

• The present study investigated the effect of dietary soy protein isolate (SPI) on tumor necrosis factor-α (TNF) productivity in peritoneal macrophages from nephritic and hepatoma-bearing rats. Dietary SPI significantly inhibited the elevated production of TNF by lipopolysaccharide-stimulated macrophages in nephritic and hepatoma-bearing rats compared with dietary casein, while it exerted no influence on the TNF productivity in normal rats. Removal of the minor components contained in SPI by ethanol extraction could significantly or partially restore the reduced TNF production caused by SPI in nephritic and hepatoma-bearing rats, respectively. These results suggest that dietary SPI could suppress the enhanced productivity of TNF associated with the progression of nephritis and hepatoma, and some factors existing in the ethanol extract of SPI are suggested to be involved in suppressing TNF productivity by macrophages.

• 日本ビタミン学会の論文

著者

• Miura Yutaka

  Department of Cardiovascular Medicine, Tohoku University Graduate School of Medicine

• YAGASAKI Kazumi

  Department of Applied Biological Science, Tokyo Noko University

• KOMATSU Wataru

  Department of Applied Biological Science, Tokyo Noko University

• NAGATA Junko

  Department of Applied Biological Science, Tokyo Noko University

• KANEKO Masaharu

  Department of Applied Biological Science, Tokyo Noko University

• YAMADA Tatsuhiko

  Department of Applied Biological Science, Tokyo Noko University

• MORIYA Daisuke

  Department of Applied Biological Science, Tokyo Noko University

• Yagasaki Kazumi

  Department Of Applied Biological Science Tokyo Noko University

• Yagasaki Kazumi

  東京農工大学

• Nagata J

  Wildlife Management Laboratory Forestry And Forest Products Research Institute

• Nagata Junko

  Division Of Bioscience Graduate School Of Environmental Earth Science Hokkaido University

• 永田 純子

  森林総合研究所鳥獣管理研究室

• Nagata Junko

  Department Of Applied Biological Science Tokyo Noko University

• Nagata Junko

  Department Of Chemico-pharmacology Faculty Of Pharmaceutical Sciences Kumamoto University

• Miura Y

  Department Of Applied Biological Science Tokyo Noko University

• Miura Yutaka

  Applied Bioresearch Center Kirin Brewry Co. Ltd.

• Miura Yutaka

  Department Of Agricultural Chemistry Faculty Of Agriculture The University Of Tokyo

• Komatsu W

  Department Of Applied Biological Science Tokyo Noko University:(present Office)department Of Hygiene

• Moriya Daisuke

  Department Of Applied Biological Science Tokyo Noko University

• Yagasaki K

  Department Of Applied Biological Science Tokyo Noko University

• Miyamoto Yoshiro

  Department Of Biochemical Engineering Faculty Of Computer Science And System Engineering Kyushu Inst

• Kaneko Masaharu

  Department Of Applied Biological Science Tokyo Noko University

• Yagasaki Kazumi

  Department Of Agricultural Chemistry Faculty Of Agriculture Tokyo Noko University

• Yamada Tatsuhiko

  Department Of Applied Biological Science Tokyo Noko University

• Miura Y

  Tokyo Noko Univ. Tokyo Jpn

• Miura Yutaka

  Dep. Of Applied Biological Sci. Tokyo Noko Univ.

• Miyamoto Yoko

  Laboratory Of Biochemistry Faculty Of Agriculture Kyushu University

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