Reduction of Renal Transforming Growth Factor-β Activity without Aggravation of Growth Retardation in Nephritic Rats by a Methionine-threonine-supplemented Low-casein Diet

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概要

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• The effects of a low-casein diet fortified with methionine and threonine on renal cortical and glomerular transforming growth factor (TGF)-β activity were studied in rats with nephritis induced by anti-rat kidney glomerular basement membrane antiserum. Both normal and nephritic rats were fed experimental diets for 10 days. An injection of nephrotoxic serum increased urinary protein excretion and renal TGF-β activity. A methionine-threonine-supplemented 8.5% casein diet, compared with a basal 20% casein diet, decreased these two measurements without aggravating growth retardation in nephritic rats. These results suggest that aggravation and alleviation of symptoms incident to anti-GBM nephritis are relevant to elevation and reduction of TGF-β activity, respectively. The results also suggest that amino acid-balanced low-protein diets would have beneficial effects on glomerulonephritis without causing severe protein malnutrition.

• 社団法人日本農芸化学会の論文
• 1997-02-23

著者

• Miura Yutaka

  Department of Cardiovascular Medicine, Tohoku University Graduate School of Medicine

• FUNABIKI Ryuhei

  Department of Applied Biological Science, Tokyo Noko University

• YAGASAKI Kazumi

  Department of Applied Biological Science, Tokyo Noko University

• FUJISAWA Kiyohito

  Department of Applied Biological Science, Tokyo Noko University

• ISHIZUKA Saori

  Department of Applied Biological Science, Tokyo Noko University

• Funabiki Ryuhei

  東京農工大学

• Funabiki Ryuhei

  Department Of Applied Biological Science Tokyo Noko University

• Funabiki Ryuhei

  Department Of Agricultural Chemistry Faculty Of Agriculture Tokyo Noko University

• Fujisawa Kiyohito

  Department Of Applied Biological Science Tokyo Noko University

• Fujisawa Kiyohito

  東京農工大学 農

• Ishizuka Saori

  Department Of Applied Biological Science Tokyo Noko University

• Yagasaki Kazumi

  Department Of Applied Biological Science Tokyo Noko University

• Yagasaki Kazumi

  東京農工大学

• Miura Y

  Department Of Applied Biological Science Tokyo Noko University

• Miura Yutaka

  Applied Bioresearch Center Kirin Brewry Co. Ltd.

• Miura Yutaka

  Department Of Agricultural Chemistry Faculty Of Agriculture The University Of Tokyo

• Yagasaki K

  Department Of Applied Biological Science Tokyo Noko University

• Miyamoto Yoshiro

  Department Of Biochemical Engineering Faculty Of Computer Science And System Engineering Kyushu Inst

• Yagasaki Kazumi

  Department Of Agricultural Chemistry Faculty Of Agriculture Tokyo Noko University

• Miura Y

  Tokyo Noko Univ. Tokyo Jpn

• Miura Yutaka

  Dep. Of Applied Biological Sci. Tokyo Noko Univ.

• Funabiki R

  Department Of Applied Biological Science Tokyo Noko University

• Miyamoto Yoko

  Laboratory Of Biochemistry Faculty Of Agriculture Kyushu University

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