Desmutagenicity of Melanoidins against Various Kinds of Mutagens and Activated Mutagens
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概要
- 論文の詳細を見る
The desmutagenic activities of low-molecular weight melanoidins (LM-MEL, MW 500-1000) and nondialyzable melanoidins (ND-MEL, MW ahove l000) prepared from a glucose-glycine reaction system were examined by Ames' test on such mutagens/carcinogens as nitro or amino compounds of aromatics or heterocycles, azo compounds, nitroso compounds, and epoxides. ND-MEL and LM-MEL exhibited a desmutagenic activity of 25-75% against mutagenic aromatic or heterocyclic compounds such as aflatoxin B_1, B[α]P, 2-aminofluorene, 4-aminobiphenyl, and 2-aminonaphthalene, as well as heterocyclic amines, using S. typhimurium TA98 in the presence of S9 mix. In the case of using S. typhimurium TA100 in the absence of S9 mix, ND-MEL and LM-MEL showed a desmutagenic activity of 20-50% against 2-nitrofluorene, 4NQO and 2-nitronaphthalene. The strong desmutagenic activity of MEL from various kinds of amino acids, peptides, or egg albumin hydrolyzates with glucose was also observed against Trp-P-1. Furthermore, MEL had marked desmutagenic activity against the Trp-P-1 activated by S9 mix and synthetic N-OH-Trp-P-2.
- 社団法人日本農芸化学会の論文
- 1994-01-23
著者
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早瀬 文孝
明治大学農学部農芸化学科
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CHUYEN Nguyen
Department of Food and Nutrition, Japan Women’s University
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Chuyen Nguyen
Dep. Of Food And Nutrition Japan Women's Univ.
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Lee I
Department Of Agricultural Chemistry The University Of Tokyo
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Lee In
東京大学 農
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Chuyen N
Department Of Food Science Japan Women's University
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Lee In-Eui
Department of Agricultural Chemistry, The University of Tokyo
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Hayase Fumitaka
Department of Agricultural Chemistry, Meiji University
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Kato Hiromichi
Department of Agricultural Chemistry, The University of Tokyo
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Lee In-eui
Department Of Agricultural Chemistry The University Of Tokyo
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Chuyen Nguyen
Department Of Food And Nutrition Japan Women's University
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Kato H
Department Of Agricultural Chemistry The University Of Tokyo
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Kato Hiromichi
Department Of Agricultural Chemistry The University Of Tokyo
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Kato Hiromichi
Department Of Food Science Ohtsuma University
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Kato H
Otsuma Women's Univ. Tokyo Jpn
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Hayase Fumitaka
Department Of Agricultural Chemistry Faculty Of Agriculture Meiji University
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Hayase Fumitaka
Department Of Agricultural Chemistry The University Of Tokyo:(present Address) Department Of Agricul
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Hayase Fumitaka
Department Of Agricultural Chemistry The University Of Tokyo : (present Address) Department Of Agric
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Hayase Fumitaka
Central Research Laboratories Asahi Breweries Ltd.
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Kato H
Department Of Applied Biological Chemistry Graduate School Of Agricultural And Life Sciences The Uni
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Hayase F
Department Of Agricultural Chemistry Meiji University
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Kato Hiroshi
Department Of Applied Biological Chemistry Graduate School Of Agricultural And Life Sciences The Uni
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Chuyen NGUYEN
Department of Agricultural Chemistry, Faculty of Agriculture, The University of Tokyo
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