Uptake of Proteins Modified with 3-Deoxyglucosone, a Maillard Reaction Intermediate, by the Type I Macrophage Scavenger Receptor
スポンサーリンク
概要
- 論文の詳細を見る
We investigated the mechanism of recognition by murine peritoneal macrophages of bovine serum albumin (BSA) modified with glucose and 3-deoxyglucosone (3DG), the main intermediate compound in the Maillard reaction of proteins with glucose. A scatchard analysis of the binding data of BSA incubated with 3DG for 17 days (3DG-BSA 17d) and of glycated BSA indicated two binding sites, each with a different binding affinity, in both cases. The apparent K_d values for the higher affinity sites of 3DG-BSA 17d and of glycated BSA were 8.5 nM and 4.6 nM, and those for the lower affinity ones were 0.95μM and 1.3μM, respectively. 3DG-BSA 17d and glycated BSA competed with each other in the specific binding to macrophages, this binding being most effectively inhibited by maleylated BSA and polyinosinic acid. The binding of 3DG-BSA 17 d and glycated BSA to the type I macrophage scavenger receptor [Kodama et al. Nature, 343, 531-535 (1990)] was investigated, because these modified BSAs share binding sites with maleylated BSA and polyinosinic acid. It was found that 3DG-BSA 17d and glycated BSA could be recognized by the type I macrophage scavenger receptor expressed on COS cells, and that the affinity of 3DG-modified BSA for the receptor increased with increasing time of incubation for BSA with 3DG. We suggest that this can be explained by the lower pI values for 3DG-BSA 17d and glycated BSA than that for the control BSA.
- 社団法人日本農芸化学会の論文
- 1993-11-23
著者
-
早瀬 文孝
明治大学農学部農芸化学科
-
Hayase Fumitaka
Department of Agricultural Chemistry, Meiji University
-
Kato Hiromichi
Department of Agricultural Chemistry, The University of Tokyo
-
Kato H
Department Of Agricultural Chemistry The University Of Tokyo
-
Kato Hiromichi
Department Of Agricultural Chemistry The University Of Tokyo
-
Kato Hiromichi
Department Of Food Science Ohtsuma University
-
SHINODA Tatsuya
Department of Biochemistry and Food Science, Faculty of Agriculture, Kagawa University
-
Kato H
Otsuma Women's Univ. Tokyo Jpn
-
Hayase Fumitaka
Department Of Agricultural Chemistry Faculty Of Agriculture Meiji University
-
Hayase Fumitaka
Department Of Agricultural Chemistry The University Of Tokyo:(present Address) Department Of Agricul
-
Hayase Fumitaka
Department Of Agricultural Chemistry The University Of Tokyo : (present Address) Department Of Agric
-
Hayase Fumitaka
Central Research Laboratories Asahi Breweries Ltd.
-
Kato H
Department Of Applied Biological Chemistry Graduate School Of Agricultural And Life Sciences The Uni
-
Hayase F
Department Of Agricultural Chemistry Meiji University
-
Kato Hiroshi
Department Of Applied Biological Chemistry Graduate School Of Agricultural And Life Sciences The Uni
-
Chuyen Van
Department of Food and Nutrition, Japan Women's University
-
Shinoda T
Sci. Univ. Tokyo Chiba Jpn
-
Shinoda Tatsuya
Department Of Biochemistry And Food Science Faculty Of Agriculture Kagawa University
-
Chuyen Van
Department Of Food And Nutrition Japan Women's University
-
Shinoda Tatsuya
Department of Agricultural Chemistry, The University of Tokyo
関連論文
- 味噌の食後血糖に及ぼす影響
- 和牛肉と輸入牛肉の香気成分
- 和牛香の香気成分の分析
- 味噌の食後血糖に及ぼす影響
- Desmutagenicity of Melanoidins against Various Kinds of Mutagens and Activated Mutagens
- Absorption and Distribution of [^14C] Melanoidins in Rats and the Desumtagenicity of Absorbed Melanoidins against Trp-P-1
- Inhibition of Nitrosamine Formation by Nondialyzable Melanoidins
- Is Median Sternotomy Invasive? A Comparison Between Minimally Invasive Direct Coronary Artery Bypass and Off-Pump Bypass
- Importance of Preoperative Marking for Minithoracotomy and for Internal Thoracic Artery Harvesting in Minimally Invasive Direct Coronary Artery Bypass Grafting
- -126- POSTOPERATIVE PULMONARY HYPERTENSION IN PATIENTS WITH PSEUDOTRUNCUS ARTERIOSUS : Congenital Heart Disease, Kawasaki Disease : FREE COMMUNICATIONS(I) : PROCEEDINGS OF THE 51th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATION SOCIETY
- Plantaricin-149,a Bacteriocin Produced by Lactobacillus plantarum NRIC 149
- Antibacterial Substances Produced by Enterococcus faecium
- Isolation of Enterococcus faecium with Antibacterial Activity and Characterization of Its Bacteriocin
- 食品加工中のメイラード反応初期段階に対する塩類の影響
- 食品中のグリコトキシン (特集 グリケーション--食品から臨床へ)
- INCREASE IN LEAKAGE OF MYOCARDIAL ENZYMES BY THE STRESS OF CARDIAC BEATING AFTER INCREASE IN CELL MEMBRANE FRAGILITY BY ANOXIA : Pathophysiology : 53 Annual Scientific Meeting, Japanese Circulation Society
- LEFT VENTRICULAR FUNCTION IN PATIENTS WITH PULMONARY VALVULAR REGURGITATION AFTER REPAIR OF TETRALOGY OF FALLOT : Congenital Heart Disease : PROCEEDINGS OF THE 50th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATION SOCIETY
- ASSESSMENT OF VENTRICULAR VOLUME CHARACTERISTICS OF SINGLE RIGHT VENTRICLE : Congenital Heart Disease, Kawasaki Disease : FREE COMMUNICATIONS (VI) : PROCEEDINGS OF THE 49th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATION SOCIETY
- QUANTITATIVE ASSESSMENT OF THE LATE CORONARY BYPASS GRAFT FLOW BY CINEDENSITOMETRIC TECHNIQUE : Ischemic Heart Disease (II), Coronary Circulation : II : 48 Annual Scientific Meeting, Japanese Circulation Society
- A Case of Arrhythmogenic Right Ventricular Dysplasia With Left and Right Ventricular Hypofunction in an Elderly Subject : Long-Term Fellow-Up
- PP-1224 OVEREXPRESSION ON HEME OXYGNENASE-1 PROTECTS STEATOTIC RAT LIVERS FROM ISCHEMIA/REPERFUSION INJURY
- Age-Related Changes in Right and Left Ventricular Function in Tetralogy of Fallot : SYMPOSIUM ON LONG-TERM MYOCARDIAL CHANGES IN HEART DISEASES : 49th Annual Scientific Session of the Japanese Circulation Society
- VENTRICULAR VOLUME, MASS AND WALL STRESS IN SINGLE VENTRICLE : COMPARISON BETWEEN LEFT AND RIGHT VENTRICLAR TYPES : Congenital Heart Disease : PROCEEDINGS OF THE 50th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATION SOCIETY
- QUANTITATIVE EVALUATION OF PULMONARY REGURGITATION AFTER REPAIR OF TETRALOGY OF FALLOT BY REAL TIME TWO-DIMENSIONAL DOPPLER COLOR FLOW IMAGING : Echocardiography (II) : FREE COMMUNICATIONS (IV) : PROCEEDINGS OF THE 49th ANNUAL SCIENTIFIC MEETING OF THE JA
- EVALUATION OF PULMONARY REGURGITATION AFTER CORRECTION OF TETRALOGY OF FALLOT BY CINEDENSITOMETRIC MEASUREMENT : Doppler, RI : I : 48 Annual Scientific Meeting, Japanese Circulation Society
- CLINICAL STUDY OF LEFT ATRIAL VOLUME AND LEFT ATRIAL COMPLIANCE IN MITRAL STENOSIS : PROCEEDINGS OF THE 47th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATION SOCIETY : Valvular Heart Disease (I)
- STUDY OF LATE ARRHYTHMIA AFTER CORRECTION OF TETRALOGY OF FALLOT WITH HOLTER AMBULATORY MONITORING : PROCEEDINGS OF THE 47th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATION SOCIETY : Arrhythmia
- The Tyrosine Kinase Activity of the Chicken Insulin Receptor Is Similar to That of the Human Insulin Receptor
- Nutritional Regulation of Insulin-like Growth Factor-I Receptor mRNA Levels in Growing Chickens
- Identification of Novel Fluorescent Pyrrolopyridinium Compound Formed from Maillard Reaction of 3-Deoxyglucosone and Butylamine
- THE ANALYSIS OF THE POSTOPERATIVE PULMONARY HEMODYNAMICS IN VIEW OF PULMONARY ARTERY DISTRIBUTION IN PULMONARY ATRESIA WITH VENTRICULAR SEPTAL DEFECT AND MAJOR AORTOPULMONARY COLLATERAL ARTERIES : Extracorporeal Circulation, Aortic Aneurysm : 53 Annual Sc
- FLOW MEASUREMENT IN THE LATE POSTOPERATIVE BLALOCK-TAUSSIG SHUNT BY CINEDENSITOMETRY : Doppler, RI : I : 48 Annual Scientific Meeting, Japanese Circulation Society
- Characterization of Endogenous Gibberellins in Dwarf Rice Mutants
- Analyses of the Chemical Structures of Melanoidins by ^C NMR, ^C and ^N CP-MAS NMR Spectrometry(Food & Nutrition)
- Decolorization and Degradation Products of Melanoidins on Ozonolysis
- -172- EVALUATION OF FUNCTIONAL TRICUSPID REGURGITATION BY THE AMOUNT OF TRICUSPID VALVE ANNULAR DILATATION IN MITRAL VALVE DISEASE : Myocardial Infarction, Valvular Heart Disease : FREE COMMUNICATIONS(I) : PROCEEDINGS OF THE 51th ANNUAL SCIENTIFIC MEETING
- Regulation of Hydroxyindole-0-methyltransferase Gene Expression in Japanese Quail (Coturnix coturnix japonica)(Biochemistry & Molecular Biology)
- Feeding a Lysine-free Diet Decreases Food Intake without Changes in Hypothalamic Monoamine Concentrations in Growing Chicks
- Feeding a Lysine-free Diet Decreases Food Intake without Changes in Hypothalamic Monoamine Concentrations in Growing Chicks
- Decrease of the Obese Gene Expression in Bovine Subcutaneous Adipose Tissue by Fasting
- 烏骨鶏における松果体中メラトニン含量のサ-カディアンリズム
- Isolation of 2R, 5R-Dihydroxymethyl-3R, 4R-dihydroxypyrrolidine (DMDP) from the Fermentation Broth of Streptomyces sp. KSC-5791
- Dietary Protein as a Potent Regulator of the Hyaluronan Synthase Gene in Rat Skin(Food & Nutrition Science)
- Effects of Protein Deprivation on α1 (I) and α1 (III) Collagen and Its Degrading System in Rat Skin(Food & Nutrition Science)
- Identification of Blue Pigment Formed in a D-Xylose-Glycine Reaction System
- Molecular Properties and Activity of Amino-Terminal Truncated Forms of Lipase Activator Protein
- Calcium Ion-Dependent Reactivation of a Pseudomonas Lipase by Its Specific Modulating Protein, LipB^1
- Semi Quantification of Gibberellins in the Anthers of Thermosensitive Genetic Male Sterile Rice (Oryza sativa L. cv. PL12)
- Enhancing Effect of Interleukin-4 on the Secretion of Interferon-γ by α_-Casein-specific CD8^+ T Cells
- α_-Casein-specific CD8^+ T Cell Clone That Inhibits Its Own Interferon-γ Production by Producing Interleukin-10
- Identification of the Modified Structure of Arginine Residues in Proteins with 3-Deoxyglucosone, a Maillard Reaction Intermediate
- Contribution to Stale Flavor of 2-Furfuryl Ethyl Ether and Its Formation Mechanism in Beer
- Isolation, Structure and Biological Activity of Trialaphos(Organic Chemistry)
- Identification of N^ε-(carboxyethyl) lysine, one of the methylglyoxalderived AGE structures, in glucose-modified protein : mechanism for protein modification by reactive aldehydes
- Microwave Dielectric Properties of the Ba_(Sm_, R_y)_Ti_O_(R=Nd and La) Solid Solutions with Zero Temperature Coefficient of the Resonant Frequency
- Microwave Dielectric Properties and Structure of the Ba_Sm_Ti_O_ Solid Solutions
- Effects of Oxygen and Transition Metals on the Advanced Maillard Reaction of Proteins with Glucose
- Kinetic Aspects of the Blue Pigment Formation in a Maillard Reaction between D-Xylose and Glycine(Food & Nutrition)
- New Method for Analyzing the Volatiles in Beer
- Evaluation by a Multivariate Analysis of the Stale Flavor Formed while Storing Beer
- Evaluation by Multivariate Analysis of Off-flavor in Headspace Volatiles Formed during Storage of Beer(Food & Nutrition)
- メイラード反応による活性酵素の生成と消去
- RE-EVALUATION OF CORONARY STENOSIS FROM AN ASPECT OF CORONARY FLOW RATE MEASURED BY CINEDENSITOMETRY : Ischemic Heart Disease (V) : FREE COMMUNICATIONS (V) : PROCEEDINGS OF THE 49th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATION SOCIETY
- Effects of Dexamethasone on the Production of Insulin-like Growth Factor-I and Insulin-like Growth Factor Binding Proteins in Primary Cultures of Rat Hepatocytes
- Polymerization of Proteins Caused bt Reaction with Sugars and the Formation of 3-Deoxyglucosone under Physiological Conditions(Food & Nutrition)
- Survey of Neutral Aminopeptidases in Bovine, Porcine, and Chicken Skeletal Muscles(Food & Nutrition)
- Components Contributing to the Improvement of Meat Taste during Storage (Food & Nutrition)
- Purification and Properties of Aminopeptidase H from Porcine Skeletal Muscle(Biological Chemistry)
- Purification and Characterization of NADPH-dependent 2-Oxoaldehyde Reductase from Chicken Liver(Biological Chemistry)
- The Effects of Aminoguanidine on 3-Deoxyglucosone in the Maillard Reaction(Biological Chemistry)
- Identification of an Intermediate Product and Formation Mechanisms of Cross-linking Compounds from N^α-Acetyltryptophan and Hexanal(Food & Nutrition)
- Novel Cross-linking Compounds Formed through the Reaction of N^α-Acetyltryptophan with Hexanal(Food & Nutrition)
- Responsibility of 3-Deoxyglucosone for the Glucose-Induced Polymerization of Proteins(Food & Nutrition)
- Characterization of Tryptophan Derivatives from the Reaction of N^α-Acetyl-tryptophan with Carbonyl Compounds(Food & Nutrition)
- Modification of Lysine Residues to Alkyl-substituted Pyridiniums on Exposure of Proteins to Vaporized Hexanal(Food & Nutrition)
- Inhibition of the Protein Crosslinking in a Maillard Reaction by Aminoguanidine and Semicarbazide(Food & Nutrition)
- Isolation and Identification of 5-Methyl-imidazolin-4-one Derivative as Glyceraldehyde-Derived Advanced Glycation End Product
- Cytotoxicity and Oxidative Stress Induced by the Glyceraldehyde-related Maillard Reaction Products for HL-60 Cells
- Protective Effect of Blue-M1 against Oxidative Stress on COS-1 Cells
- アミノカルボニル反応 - 褐色色素メラノイジンの生成機構 -
- Formation of N-(1-Oxo-2,4,5,6-hydroxyhexyl)-2'-deoxyguanosine by the Reaction of 2'-Deoxyguanosine with 3-Deoxyglucosone
- Suppression of Cell-cycle Progression during the S Phase of Rat Fibroblasts by 3-Deoxyglucosone, a Maillard Reaction Intermediate
- Novel Imidazolone Compound Formed by the Advanced Maillard Reaction of 3-Deoxyglucosone and Arginine Residues in Proteins
- Uptake of Proteins Modified with 3-Deoxyglucosone, a Maillard Reaction Intermediate, by the Type I Macrophage Scavenger Receptor
- Aldose Reductase from Porcine Liver Metabolizing 3-Deoxyglucosone, a Maillard Reaction Intermediate
- Scavenging of Active Oxygen Species by Glycated Proteins
- Precipitate-forming Reaction of β-(1→4)-D-Glucanase(I) in Malt(Biological Chemistry)
- Purification and Properties of Aminopeptidase C from Chicken Skeletal Muscle(Food & Nutrition)
- Identification of Neutral Aminopeptidases Responsible for Peptidolysis in Postmortem Rabbit Skeletal Muscle (Food & Nutrition)
- Polymerization of Acetylated Lysozyme and Impairment of Their Amino Acid Residues Due to α-Dicarbonyl and α-Hydroxycarbonyl Compounds(Food & Nutrition)
- Identification and Determination of α-Dicarbonyl Compounds Formed in the Degradation of Sugars
- The Formation of Argpyrimidine in Glyceraldehyde-Related Glycation
- Detection and Determination of Glyceraldehyde-Derived Pyridinium-Type Advanced Glycation End Product in Streptozotocin-Induced Diabetic Rats
- Purification and Characterization of NAD-dependent Alcohol Dehydrogenase and NADH-dependent 2-Oxoaldehyde Reductase from Parsley(Food & Nutrition)
- Purification and Characterization of NADPH-dependent 2-Oxoaldehyde Reductase from Parsley(Food & Nutrition)
- Scavenging of Active Oxygens by Melanoidins(Food & Nutrition)
- 3-Deoxyglucosone-metabolizing Enzymes in Plants: NADPH-dependent 2-Oxoaldehyde Reductase of Parsley(Foof & Nutrition)
- メイラード反応による着色機構 : メラノイジン前駆体 Blue-M1 と褐変との関わりを探る
- 大麦の炊飯香気の特徴に寄与する成分
- Polymerization of Lysozyme by Reacting with Vaporized Hexanal