Effects of Oxygen and Transition Metals on the Advanced Maillard Reaction of Proteins with Glucose
スポンサーリンク
概要
- 論文の詳細を見る
The generation of fluorescence and 3-deoxyglucosone (3DG), browning, polymerization, and impairment of the amino acid residues of lysozyme incubated with glucose were investigated at 37℃ and 50℃ at pH 7.4 in a phosphate or TAPSO buffer under aerobic and non-aerobic conditions with or without DETAPAC as a chelating reagent. Browning, the generation of fluorescence, and polymerization were accelerated under the non-aerobic, compared to aerobic, conditions. Moreover, the formation of 3DG was also significantly increased under non-aerobic conditions. The incubation of both reaction systems resulted in noticeable losses of arginine and lysine residues. DETAPAC significantly inhibited the advanced Maillard reaction under both aerobic and non-aerobic conditions. However, DETAPAC had no effect on the impairment of lysine and arginine residues. The generation of fluorescence, browning and polymerization of lysozyme in the TAPSO buffer were markedly inhibited under both aerobic and non-aerobic conditions. These observations suggest that transition metals in the phosphate buffer may have accelerated the formation of Amadori compounds via Schiff's base. In addition, under non-aerobic conditions, the formation of advanced glycation end products from 3DG via Amadori compounds is presumed to be the major pathway, because the formation of N^ε-(carboxymethyl)lysine, glyoxal, and glucosone was accelerated by an oxidative reaction catalyzed with transition metal ions. These presumptions are supported by the results from a lysozyme-3DG reaction system.
- 社団法人日本農芸化学会の論文
- 1996-11-23
著者
-
SATO Junichi
Department of Radiology, Asahikawa Medical College
-
Hayase Fumitaka
Department of Agricultural Chemistry, Meiji University
-
SHIBUYA TAKESHI
Department of Pharmacology Tokyo Medical College
-
Hayase Fumitaka
Department Of Agricultural Chemistry Faculty Of Agriculture Meiji University
-
Shibuya Takeshi
Department Of Agricultural Chemistry Meiji University
-
YAMAMOTO Masatomo
Department of Agricultural Chemistry, Meiji University
-
Yamamoto Masatomo
Department Of Agricultural Chemistry Meiji University
-
Sato Junichi
Department Of Agricultural Chemistry Meiji University
関連論文
- Molecular Characteristics of Bovine Serum Albumin-Dextran Conjugates
- Improved accuracy in estimation of left ventricular function parameters from QGS software with Tc-99m tetrofosmin gated-SPECT: a multivariate analysis.
- Desmutagenicity of Melanoidins against Various Kinds of Mutagens and Activated Mutagens
- Absorption and Distribution of [^14C] Melanoidins in Rats and the Desumtagenicity of Absorbed Melanoidins against Trp-P-1
- Inhibition of Nitrosamine Formation by Nondialyzable Melanoidins
- Chlorella vulgaris Aldehyde Reductase Is Capable of Functioning as Ferric Reductase and of Driving the Fenton Reaction in the Presence of Free Flavin
- Changes in Nitric Oxide Generated by the Oxidation of Oxymyoglobin by Nitrite
- Identification of Novel Fluorescent Pyrrolopyridinium Compound Formed from Maillard Reaction of 3-Deoxyglucosone and Butylamine
- Analyses of the Chemical Structures of Melanoidins by ^C NMR, ^C and ^N CP-MAS NMR Spectrometry(Food & Nutrition)
- Decolorization and Degradation Products of Melanoidins on Ozonolysis
- Inhibitory Effects of Newly Synthesized Ser-Contained GABA-Peptides Administered into either Caudate Putamen or Amygdala on Methamphetamine-Induced Hyperactivity
- Identification of Blue Pigment Formed in a D-Xylose-Glycine Reaction System
- Identification of the Modified Structure of Arginine Residues in Proteins with 3-Deoxyglucosone, a Maillard Reaction Intermediate
- Contribution to Stale Flavor of 2-Furfuryl Ethyl Ether and Its Formation Mechanism in Beer
- Identification of N^ε-(carboxyethyl) lysine, one of the methylglyoxalderived AGE structures, in glucose-modified protein : mechanism for protein modification by reactive aldehydes
- Observation of the Initial Stage of Ion Assisted Deposition Films Using a Rotating-Analyzer Ellipsometer
- 回転移相子型偏光解析装置の測定精度に関する研究
- Four-detector photopolarimeter(FDP)の試作とその応用
- Effects of Oxygen and Transition Metals on the Advanced Maillard Reaction of Proteins with Glucose
- 金蒸着膜の成膜過程のエリプソメトリーによる観察
- Kinetic Aspects of the Blue Pigment Formation in a Maillard Reaction between D-Xylose and Glycine(Food & Nutrition)
- New Method for Analyzing the Volatiles in Beer
- Evaluation by a Multivariate Analysis of the Stale Flavor Formed while Storing Beer
- Evaluation by Multivariate Analysis of Off-flavor in Headspace Volatiles Formed during Storage of Beer(Food & Nutrition)
- ANALYSES OF ACTIVE SUBSTANCES DYNAMICS IN THE CENTRAL NORADRENERGIC, DOPAMINERGIC, SEROTONERGIC, CHOLINERGIC AND AMINO ACIDERGIC NERVOUS SYSTEMS BY HPLC-MULTIPLE COULOMETRIC ECD
- Polymerization of Proteins Caused bt Reaction with Sugars and the Formation of 3-Deoxyglucosone under Physiological Conditions(Food & Nutrition)
- Tran^S-labeling of cercariae of Schistosoma mansoni: a less expensive tool for tracing in vivo migration of schistosomula in mice
- Predicting lymph node metastasis of oral cancer examined by cell proliferation maker Ki67
- Purification and Characterization of NADPH-dependent 2-Oxoaldehyde Reductase from Chicken Liver(Biological Chemistry)
- Identification of an Intermediate Product and Formation Mechanisms of Cross-linking Compounds from N^α-Acetyltryptophan and Hexanal(Food & Nutrition)
- Novel Cross-linking Compounds Formed through the Reaction of N^α-Acetyltryptophan with Hexanal(Food & Nutrition)
- Responsibility of 3-Deoxyglucosone for the Glucose-Induced Polymerization of Proteins(Food & Nutrition)
- Characterization of Tryptophan Derivatives from the Reaction of N^α-Acetyl-tryptophan with Carbonyl Compounds(Food & Nutrition)
- Modification of Lysine Residues to Alkyl-substituted Pyridiniums on Exposure of Proteins to Vaporized Hexanal(Food & Nutrition)
- Inhibition of the Protein Crosslinking in a Maillard Reaction by Aminoguanidine and Semicarbazide(Food & Nutrition)
- C_3-Functionalized Cyclotriveratrylene Derivative Bearing Quinolinyl Group as a Fluorescent Probe for Cu^
- Isolation and Identification of 5-Methyl-imidazolin-4-one Derivative as Glyceraldehyde-Derived Advanced Glycation End Product
- Cytotoxicity and Oxidative Stress Induced by the Glyceraldehyde-related Maillard Reaction Products for HL-60 Cells
- Protective Effect of Blue-M1 against Oxidative Stress on COS-1 Cells
- Formation of N-(1-Oxo-2,4,5,6-hydroxyhexyl)-2'-deoxyguanosine by the Reaction of 2'-Deoxyguanosine with 3-Deoxyglucosone
- Suppression of Cell-cycle Progression during the S Phase of Rat Fibroblasts by 3-Deoxyglucosone, a Maillard Reaction Intermediate
- Novel Imidazolone Compound Formed by the Advanced Maillard Reaction of 3-Deoxyglucosone and Arginine Residues in Proteins
- Uptake of Proteins Modified with 3-Deoxyglucosone, a Maillard Reaction Intermediate, by the Type I Macrophage Scavenger Receptor
- Aldose Reductase from Porcine Liver Metabolizing 3-Deoxyglucosone, a Maillard Reaction Intermediate
- Scavenging of Active Oxygen Species by Glycated Proteins
- Chlorella vulgaris Aldehyde Reductase Is Capable of Functioning as Ferric Reductase and of Driving the Fenton Reaction in the Presence of Free Flavin
- Antioxidative Activity of the Blue Pigment Formed in a D-Xylose-Glycine Reaction System(Food & Nutrition Science)
- Identification and Determination of α-Dicarbonyl Compounds Formed in the Degradation of Sugars
- Relation between Age-Related Changes in Hyper-Emotionality and Serotonergic Neuronal Activities in the Rat Limbic System
- Identification of the Blue Pigment Formed in a D-Glucose-Glycine Reaction System
- Isolation and Identification of the 3-Hydroxy-5-hydroxymethyl-pyridinium Compound as a Novel Advanced Glycation End Product on Glyceraldehyde-related Maillard Reaction(Food & Nutrition Science)
- The Formation of Argpyrimidine in Glyceraldehyde-Related Glycation
- Detection and Determination of Glyceraldehyde-Derived Pyridinium-Type Advanced Glycation End Product in Streptozotocin-Induced Diabetic Rats
- EXAMINATION OF SLOPE HAZARD ASSESSMENT BY USING CASE STUDIES OF EARTHQUAKE- AND RAINFALL-INDUCED LANDSLIDES(Geotechnical Disasters in 2004 and 2005)
- Genetic Characterization of Cultured Populations of Japanese Common Carp
- Purification and Characterization of NAD-dependent Alcohol Dehydrogenase and NADH-dependent 2-Oxoaldehyde Reductase from Parsley(Food & Nutrition)
- Identification of Red Pigments Formed in a D-Xylose-glycine Reaction System
- Identification of a Novel Blue Pigment as a Melanoidin Intermediate in the D-Xylose-Glycine Reaction System
- Purification and Characterization of NADPH-dependent 2-Oxoaldehyde Reductase from Parsley(Food & Nutrition)
- Scavenging of Active Oxygens by Melanoidins(Food & Nutrition)
- 3-Deoxyglucosone-metabolizing Enzymes in Plants: NADPH-dependent 2-Oxoaldehyde Reductase of Parsley(Foof & Nutrition)
- A Suitable Detection Mode for Rapid, Highly Sensitive and Simultaneous Determination of Various Biogenic Amines by Coulometric HPLC
- Determination of Glyceraldehyde Formed in Glucose Degradation and Glycation
- Differential, Postnatal Ontogeny of Opiate and Benzodiazepine Receptor Subtypes in Rat Cerebral Cortex: Binding Characteristics of Tifluadom and Brotizolam
- Volatile Components Formed by Thermal Degradation of Nondialyzable Melanoidin Prepared from a Sugar-Butylamine Reaction System
- Comparison of Typical and Atypical Benzodiazepines on the Central and Peripheral Benzodiazepine Receptors
- Trapping of Magnetic Domain Wall in Nickel Constriction
- Lignification and Qualitative Changes of Phenolic Compounds in Rice Callus Tissues Inoculated with Plant Pathogenic Fungi
- Comparative Studies on the Inhibitory Effects of Calcium Antagonists on Cytosolic Ca2+Levels Increased by High-Potassium or Glutamate in Cultured Rat Cerebellar Granule Cells.
- A STUDY ON THE PHARMACOLOGICAL ACTION OF LAUDOLISSIN
- Developmental alterations in maturing rats caused by chronic prenatal and postnatal diazepam treatments.
- Trials for Evaluating the Central Actions of Drugs using the Locomotor Activity of SHR Increased by a Novel Circumstances utilizing a Mild Audio Stressor
- Precipitate-forming Reaction of β-(1→4)-D-Glucanase(II) in Malt
- Decolorization and Degradation Products of the Melanoidins by Hydrogen Peroxide
- 3-Deoxyglucosone Crosslinks Proteins under Physiological Conditions
- Desmutagenicity of Melanoidins against Mutagenic Pyrolysates
- Structure-affinity relationships between several new benzodiazepine derivatives and 3H-diazepam receptor sites.
- Volatile and Nonvolatile Maillard Reaction Products between L-Lysine and D-Glucose