Formation of N-(1-Oxo-2,4,5,6-hydroxyhexyl)-2'-deoxyguanosine by the Reaction of 2'-Deoxyguanosine with 3-Deoxyglucosone
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概要
- 論文の詳細を見る
3-Deoxyglucosone (3DG) has weaker mutagenicity than methylglyoxal by the Ames test. 3DG reacted readily with 2'-deoxyguanosine (dG) in nucleosides. Two major products (G-A and G-B) were isolated and purified from the reaction mixture of 50 mM 3DG and 50 mM dG at 50℃ and pH 7.4 for 6d. G-A was identified as N-(1-oxo-2,4,5,6-hydroxyhexyl)-2'-deoxyguanosine. G-B was identified as a diastereomer of G-A.
- 社団法人日本農芸化学会の論文
- 1998-08-23
著者
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早瀬 文孝
明治大学農学部農芸化学科
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早瀬 文孝
日清ファルマ健康科学研究所
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Hayase Fumitaka
Department of Agricultural Chemistry, Meiji University
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Hayase Fumitaka
Department Of Agricultural Chemistry Faculty Of Agriculture Meiji University
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Hayase Fumitaka
Department Of Agricultural Chemistry The University Of Tokyo:(present Address) Department Of Agricul
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Hayase Fumitaka
Department Of Agricultural Chemistry The University Of Tokyo : (present Address) Department Of Agric
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Hayase Fumitaka
Central Research Laboratories Asahi Breweries Ltd.
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Hayase F
Department Of Agricultural Chemistry Meiji University
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KANEKO KOJI
Department of Surgery I, Niigata University School of Medicine
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Hayase Fumitaka
Dep. Of Agricultural Chemistry Fac. Of Agriculture Meiji Univ.
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Kaneko Koji
Department Of Agricultural Chemistry Meiji University
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