Aldose Reductase from Porcine Liver Metabolizing 3-Deoxyglucosone, a Maillard Reaction Intermediate
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概要
- 論文の詳細を見る
An enzyme which catalyzes the NADPH-dependent reduction of 3-deoxyglucosone (3DG) was isolated and purified from porcine liver by ammonium sulfate fractionation, and DEAE-cellulose, hydroxyapatite, Sephadex G-100,Blue Sepharose CL-6B, and Sephadex G-100 column chromatographies. The pH for optimum enzyme activity was 6.5. 3DG was a good substrate, and glucose and fructose could also be reduced at a significant rate. The K_m values for 3DG, methylglyoxal and glyceraldehyde were 2.5,1.9,and 4.9mM, respectively. The molecular mass of the enzyme was estimated to be 67,000,and the enzyme is proposed to be a dimer composed of identical subunits. The activity of the enzyme was completely inhibited by p-chloromercuribenzoate, and the enzyme is estimated to be an aldose reductase.
- 社団法人日本農芸化学会の論文
- 1992-07-23
著者
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早瀬 文孝
明治大学農学部農芸化学科
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Hayase Fumitaka
Department of Agricultural Chemistry, Meiji University
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Kato Hiromichi
Department of Agricultural Chemistry, The University of Tokyo
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Kato H
Department Of Agricultural Chemistry The University Of Tokyo
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Kato Hiromichi
Department Of Agricultural Chemistry The University Of Tokyo
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Kato Hiromichi
Department Of Food Science Ohtsuma University
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Kato H
Otsuma Women's Univ. Tokyo Jpn
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Hayase Fumitaka
Department Of Agricultural Chemistry Faculty Of Agriculture Meiji University
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Hayase Fumitaka
Department Of Agricultural Chemistry The University Of Tokyo:(present Address) Department Of Agricul
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Kato H
Department Of Applied Biological Chemistry Graduate School Of Agricultural And Life Sciences The Uni
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Hayase F
Department Of Agricultural Chemistry Meiji University
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Liang Zhi-qun
Department Of Agricultural Chemistry The University Of Tokyo
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Kato Hiroshi
Department Of Applied Biological Chemistry Graduate School Of Agricultural And Life Sciences The Uni
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