Detection and Determination of Glyceraldehyde-Derived Pyridinium-Type Advanced Glycation End Product in Streptozotocin-Induced Diabetic Rats
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概要
- 論文の詳細を見る
GLAP, glyceraldehyde-derived pyridinium-type advanced glycation end product (AGE), formed by glyceraldehyde-related glycation, was identified in the plasma protein and the tail tendon collagen of streptozotocin (STZ)-induced diabetic rats. It was detected in the plasma protein and the collagen in diabetic rats by LC-MS and LC-MS/MS analysis, but was not detected in normal rats. In addition, GLAP was formed from glyceraldehyde-3-phosphate (GA3P) with lysine as well as glyceraldehyde (GLA) with lysine in vitro. Accordingly, it is suggested that an increase in the GLAP level reflects an increase in the GLA level and the GA3P level. GLAP might be a biomarker for reduced activity of the glyceraldehyde-related enzymes in the metabolic diseases such as diabetic complications.
- 社団法人 日本農芸化学会の論文
- 2007-02-23
著者
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早瀬 文孝
明治大学農学部農芸化学科
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早瀬 文孝
日清ファルマ健康科学研究所
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Watanabe Hirohito
Department Of Applied Biological Chemistry Graduate School Of Agricultural And Life Science The Univ
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Hayase Fumitaka
Department Of Agricultural Chemistry Faculty Of Agriculture Meiji University
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Hayase Fumitaka
Department Of Agricultural Chemistry The University Of Tokyo:(present Address) Department Of Agricul
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Hayase Fumitaka
Department Of Agricultural Chemistry The University Of Tokyo : (present Address) Department Of Agric
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Hayase Fumitaka
Central Research Laboratories Asahi Breweries Ltd.
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Hayase F
Department Of Agricultural Chemistry Meiji University
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USUI Teruyuki
Department of Agricultural Chemistry, Faculty of Agriculture, Meiji University
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Hayase Fumitaka
Dep. Of Agricultural Chemistry Fac. Of Agriculture Meiji Univ.
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Usui Teruyuki
Department Of Agricultural Chemistry Faculty Of Agriculture Meiji University
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SHIMOHIRA Kazuhito
Department of Agricultural Chemistry, Faculty of Agriculture, Meiji University
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Shimohira Kazuhito
Department Of Agricultural Chemistry Faculty Of Agriculture Meiji University
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