Isolation and Identification of 5-Methyl-imidazolin-4-one Derivative as Glyceraldehyde-Derived Advanced Glycation End Product

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概要

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• We isolated and identified the glyceraldehyde-derived advanced glycation product (AGE) formed from glyceraldehyde and Nα-acetylarginine. A major product was identified as Nα-acetyl-Nδ-(5-methyl-imidazolin-4-one-2-yl)-ornithine. The compound has been reported as methylglyoxal-derived AGE, MG-H1. This study suggests that MG-H1 is formed through both glyceraldehyde-related and methylglyoxal-related pathways. There is a possibility that MG-H1 becomes an index of injury to glyceraldehyde and methylglyoxal-related enzymes.

• 社団法人 日本農芸化学会の論文
• 2006-06-23

著者

• 早瀬 文孝

  明治大学農学部農芸化学科

• 早瀬 文孝

  日清ファルマ健康科学研究所

• Hayase Fumitaka

  Department of Agricultural Chemistry, Meiji University

• WATANABE Hirohito

  Department of Applied Biological Chemistry, Graduate School of Agricultural and Life Science, The Un

• Watanabe Hirohito

  Department Of Applied Biological Chemistry Graduate School Of Agricultural And Life Science The Univ

• Hayase Fumitaka

  Department Of Agricultural Chemistry Faculty Of Agriculture Meiji University

• Hayase Fumitaka

  Department Of Agricultural Chemistry The University Of Tokyo:(present Address) Department Of Agricul

• Hayase Fumitaka

  Department Of Agricultural Chemistry The University Of Tokyo : (present Address) Department Of Agric

• Hayase Fumitaka

  Central Research Laboratories Asahi Breweries Ltd.

• Hayase F

  Department Of Agricultural Chemistry Meiji University

• USUI Teruyuki

  Department of Agricultural Chemistry, Faculty of Agriculture, Meiji University

• Hayase Fumitaka

  Dep. Of Agricultural Chemistry Fac. Of Agriculture Meiji Univ.

• Usui Teruyuki

  Department Of Agricultural Chemistry Faculty Of Agriculture Meiji University

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