Determination of Glyceraldehyde Formed in Glucose Degradation and Glycation
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概要
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Glyceraldehyde (GLA) was determined in glucose degradation and glycation. GLA was detected as a decahydroacridine-1,8-dione derivative on reversed phase HPLC using cyclohexane-1,3-dione derivatizing reagent. The glucose-derived GLA level was higher than the glycation-derived GLA level, because GLA was converted to intermediates and advanced glycation end products (AGE) in glycation. GLA was also generated from 3-deoxyglucosone and glucosone as intermediates of glucose degradation and glycation. This study suggests that glyceraldehyde is generated by hyperglycemia in diabetes, and that it is also formed in medicines such as peritoneal dialysis solution.
- 社団法人 日本農芸化学会の論文
著者
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Watanabe Hirohito
Department Of Applied Biological Chemistry Graduate School Of Agricultural And Life Science The Univ
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Hayase Fumitaka
Department Of Agricultural Chemistry Faculty Of Agriculture Meiji University
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Yoshino Miku
Department Of Agricultural Chemistry Faculty Of Agriculture Meiji University
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Usui Teruyuki
Department Of Agricultural Chemistry Faculty Of Agriculture Meiji University
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