Responsibility of 3-Deoxyglucosone for the Glucose-Induced Polymerization of Proteins(Food & Nutrition)
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概要
- 論文の詳細を見る
The present work was conducted to identify the carbonyl compounds responsible for the glucose-induced polymerization of proteins and the impairment of their amino acid residues. Non-nitrogenous intermediate products of the Maillard reaction (IMR) were prepared through the reaction of glucose with butylamine, and the most major product was identified as 3-deoxyglucosone (3DG) by mass spectrometry and ^<13>C NMR. Thus, 3DG was purified from IMR and stored with proteins. 3DG polymerized both lysozyme and acetylated lysozyme, and impaired Arg, Lys and Trp residues of lysozyme, and Arg and Trp residues of acetylated lysozyme, when incubated at 50℃ and 75% relative humidity for 3 days. The elution pattern of the impaired Arg residues during an amino acid analysis was exactly the same as that observed in the glucose-induced modification of lysozyme. 3DG induced the same alteration in ovalbumin, bovine serum albumin and insulin, as that in lysozyme. All these results indicate that 3DG was the cross-linker responsible for the glucose-induced polymerization of proteins, and the attacker of their Arg, Lys and Trp residues.
- 社団法人日本農芸化学会の論文
- 1987-03-22
著者
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早瀬 文孝
明治大学農学部農芸化学科
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Hayase Fumitaka
Department of Agricultural Chemistry, Meiji University
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Kato Hiromichi
Department of Agricultural Chemistry, The University of Tokyo
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Cho Rae
Department Of Agricultural Chemistry The University Of Tokyo
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Kato H
Univ. Tokyo Tokyo Jpn
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Kato H
Department Of' Agricultural Chemistry The University Of Tokyo
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Kato Hiromichi
Department Of Agricultural Chemistry The University Of Tokyo
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Hayase Fumitaka
Department Of Agricultural Chemistry Faculty Of Agriculture Meiji University
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Hayase Fumitaka
Department Of Agricultural Chemistry The University Of Tokyo:(present Address) Department Of Agricul
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Hayase F
Department Of Agricultural Chemistry Meiji University
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OKITANI Akihiro
Department of Animal Products Science and Technology, Nippon Veterinary and Zootechnical College
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Okitani A
Faculty Of Veterinary And Animal Science Nippon Veterinary And Animal Science University
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OKITANI Akihiro
Department of Agricultural Chemistry, Faculty of Agriculture, The University of Tokyo
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