Protective Effect of Blue-M1 against Oxidative Stress on COS-1 Cells

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概要

• 論文の詳細を見る

•   Blue-M1 is a blue pigment formed from xylose and glycine in the Maillard reaction. Previous work revealed that Blue-M1 scavenged hydroxyl radicals, and prevented the autoxidation of linoleic acid in vitro. We investigated the protective effect of Blue-M1 for 2,2′-azobis(2-amidino-propane)dihydrochloride (AAPH)-induced toxicity in COS-1 cells.  COS-1 cells were cultured in AAPH containing DMEM medium with or without Blue-M1 at 37°C for 24 h. Blue-M1 decreased the AAPH-induced toxicity in COS-1 cells, and this effect was dose-dependent. Furthermore, COS-1 cells were treated with diphenyl-1-pyrenylphosphine (DPPP), as a reagent for the detection of lipid peroxide, and then were cultured in AAPH containing DMEM medium with or without Blue-M1 at 37°C for 6 h. Blue-M1 prevented the AAPH-induced peroxidation of cell membrane on COS-1 cells, and this effect was also dose-dependent. These results suggest that Blue-M1 prevents the oxidative cell injury. Therefore, Blue-M1 will be an antioxidant, which protect against the oxidative stress in living systems.

• 社団法人 日本農芸化学会の論文
• 2004-01-23

著者

• 早瀬 文孝

  明治大学農学部農芸化学科

• 早瀬 文孝

  日清ファルマ健康科学研究所

• Hayase Fumitaka

  Department of Agricultural Chemistry, Meiji University

• WATANABE Hirohito

  Department of Applied Biological Chemistry, Graduate School of Agricultural and Life Science, The Un

• Watanabe Hirohito

  Department Of Applied Biological Chemistry Graduate School Of Agricultural And Life Science The Univ

• Hayase Fumitaka

  Department Of Agricultural Chemistry Faculty Of Agriculture Meiji University

• Hayase Fumitaka

  Department Of Agricultural Chemistry The University Of Tokyo:(present Address) Department Of Agricul

• Hayase Fumitaka

  Department Of Agricultural Chemistry The University Of Tokyo : (present Address) Department Of Agric

• Hayase Fumitaka

  Central Research Laboratories Asahi Breweries Ltd.

• Hayase F

  Department Of Agricultural Chemistry Meiji University

• USUI Teruyuki

  Department of Agricultural Chemistry, Faculty of Agriculture, Meiji University

• SHIZUUCHI Satomi

  Department of Agricultural Chemistry, Faculty of Agriculture, Meiji University

• Hayase Fumitaka

  Dep. Of Agricultural Chemistry Fac. Of Agriculture Meiji Univ.

• Usui Teruyuki

  Department Of Agricultural Chemistry Faculty Of Agriculture Meiji University

• Shizuuchi Satomi

  Department Of Agricultural Chemistry Faculty Of Agriculture Meiji University

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