Cytotoxicity and Oxidative Stress Induced by the Glyceraldehyde-related Maillard Reaction Products for HL-60 Cells

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概要

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• We demonstrated the cytotoxicity of glyceraldehyde-related Maillard reaction products for HL-60 cells. Glyceraldehyde-modified bovine serum albumin and glyceraldehyde-modified casein inhibited the proliferation of HL-60 cells. The reaction products formed from glyceraldehyde and Nα-acetyllysine had also a cytotoxic effect on HL-60 cells. The cytotoxic effect was prevented by N-acetylcysteine or pyrrolidinedithiocarbamate as the antioxidants. In addition, the reaction products depressed the intracellular glutathione level, and induced the reactive oxygen species (ROS) production. These results suggested that the glyceraldehyde-related advanced glycation end products (AGEs) induced the cytotoxicity and the oxidative stress.We previously reported that the glyceraldehyde-related AGE was identified as 1-(5-acetylamino-5-carboxypentyl)-3-hydroxy-5-hydroxymethyl-pyridinium, named GLAP (glyceraldehyde-derived pyridinium compound), formed from glyceraldehyde and Nα-acetyllysine (Biosci. Biotechnol. Biochem., 67, 930–932 (2003)). In this study, GLAP inhibited the proliferation of HL-60 cells, and the inhibitory effect was prevented by the antioxidants. Furthermore, GLAP depressed the intracellular glutathione level, and induced the ROS production.This work indicated the possibility that the cytotoxicity and the oxidative stress in the progression of diabetic complications and chronic renal disease might be induced by GLAP.

• 社団法人 日本農芸化学会の論文
• 2004-02-23

著者

• 早瀬 文孝

  明治大学農学部農芸化学科

• 早瀬 文孝

  日清ファルマ健康科学研究所

• Hayase Fumitaka

  Department of Agricultural Chemistry, Meiji University

• WATANABE Hirohito

  Department of Applied Biological Chemistry, Graduate School of Agricultural and Life Science, The Un

• Watanabe Hirohito

  Department Of Applied Biological Chemistry Graduate School Of Agricultural And Life Science The Univ

• Hayase Fumitaka

  Department Of Agricultural Chemistry Faculty Of Agriculture Meiji University

• Hayase Fumitaka

  Department Of Agricultural Chemistry The University Of Tokyo:(present Address) Department Of Agricul

• Hayase Fumitaka

  Department Of Agricultural Chemistry The University Of Tokyo : (present Address) Department Of Agric

• Hayase Fumitaka

  Central Research Laboratories Asahi Breweries Ltd.

• Hayase F

  Department Of Agricultural Chemistry Meiji University

• USUI Teruyuki

  Department of Agricultural Chemistry, Faculty of Agriculture, Meiji University

• SHIZUUCHI Satomi

  Department of Agricultural Chemistry, Faculty of Agriculture, Meiji University

• Hayase Fumitaka

  Dep. Of Agricultural Chemistry Fac. Of Agriculture Meiji Univ.

• Usui Teruyuki

  Department Of Agricultural Chemistry Faculty Of Agriculture Meiji University

• Shizuuchi Satomi

  Department Of Agricultural Chemistry Faculty Of Agriculture Meiji University

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