Absorption and Distribution of [^14C] Melanoidins in Rats and the Desumtagenicity of Absorbed Melanoidins against Trp-P-1

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Two kinds of melanoidins formed between glucose and glycine with average molecular weights of 800 (low-MW MEL) and 3000 (high-MW MEL) were investigated for their absorption and distribution in rats. Seven hours after its oral administration, [^14C] low-MW MEL underwent absorption by 12.8%, which was distributed in liver, kidney, urine, blood, and breath (CO_2) with percentages of 2.2,0.5,5.7,1.2,and 3.1,respectively. On the other hand, [^14C] high-MW MEL was absorbed to a lesser extent (less than 1% of the initial administration). The results of gel permeation chromatography analyses for melanoidins showed that [^14C] high-MW MEL and [^14C] low-MW MEL with average MWs of 2000 and 500,respectively, were excreted into the urine, and that 80% of [^14C] low-MW MEL was present in a from bound to protein in the plasma. The protein-bound MEL had a desmutagenic activity against Trp-P-1. It thus is reasonable to consider that absorbed MEL (MW above 500) and protein-bound MEL may actually act as desmutagens in vivo.
社団法人日本農芸化学会の論文
1992-01-23