PGK1 Induction by a Hydrogen Peroxide Treatment Is Suppressed by Antioxidants in Human Colon Carcinoma Cells
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概要
- 論文の詳細を見る
Few protein biomarkers for oxidative stress have been reported. In this study, we attempted to identify the proteins selectively overexpressed in human colon tumor cells by treating with hydrogen peroxide as oxidative stress. A proteomic analysis followed by western blotting showed that phosphoglycerate kinase 1 (PGK1) was induced by hydrogen peroxide in a dose-dependent manner, while its expression was suppressed by a co-treatment with delphinidin, a known antioxidant. Furthermore, several antioxidants, including α-tocopherol, butylated hydroxytoluene (BHT), and Trolox, also inhibited the PGK1 induction caused by hydrogen peroxide. The data suggest that PGK1 might be a potential protein biomarker of intracellular oxidative status.
- 社団法人 日本農芸化学会の論文
- 2008-07-23
著者
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LEE In
Department of Anatomy and Cell Biology, College of Veterinary Medicine and BK21 Program for Veterina
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HA Young
Department of Pharmacy, Pusan National University
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KIM Jong-Sang
Department of Animal Science and Biotechnology, Kyungpook National University
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Sung Mi-kyung
Department Of Food And Nutrition Sookmyung Women's University
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JANG Chan
Department of Animal Science and Biotechnology, Kyungpook National University
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LIM Jinkyu
Department of Animal Science and Biotechnology, Kyungpook National University
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LEE Sung-Joon
Division of Food Bioscience and Technology, Korea University
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Lee In
Department Of Agronomy College Of Agriculture And Life Sciences Kyungpook National University
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Kim Jong-sang
Department Of Animal Science And Biotechnology Kyungpook National University
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Sung Mi-kyung
Dep. Of Food And Nutrition Sookmyung Women's Univ.
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Lee Sung-joon
Division Of Food Bioscience And Technology Korea University
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Lim Jinkyu
Department Of Animal Science And Biotechnology Kyungpook National University
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Jang Chan
Department Of Animal Science And Biotechnology Kyungpook National University
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Lee In
Department Of Animal Science And Biotechnology Kyungpook National University
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Ha Young
Department Of Animal Science And Biotechnology Kyungpook National University
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Lee In
Department Of Aerospace Engineering
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