Evaluation of Aloin and Aloe-Emodin as Anti-Inflammatory Agents in Aloe by Using Murine Macrophages

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概要

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• The aloe ingredients responsible for physiological effects and the concentrations required to exert their biological activities are not fully understood. This study compares the anti-inflammatory effects of aloin and aloe-emodin with other polyphenols. Our results demonstrated that aloe-emodin dose-dependently inhibited inducible nitric oxide synthase (iNOS) mRNA expression and nitric oxide (NO) production at 5–40 μM. In addition, the levels of cyclooxygenase-2 (COX-2) mRNA and prostaglandin E2 (PGE2) production were suppressed by 40 μM aloe-emodin. Aloin also suppressed the production of NO at 5–40 μM, although it did not suppress PGE2 production. The present results indicate that aloin and aloe-emodin possibly suppress the inflammatory responses by blocking iNOS and COX-2 mRNA expression. The anti-inflammatory effect of aloe-emodin was comparable to that of kaempferol and quercetin, indicating aloe-emodin as a possible key constituent responsible for the anti-inflammatory activity of aloe.

• 社団法人 日本農芸化学会の論文
• 2009-04-23

著者

• Park Mi-young

  Department Of Computer Engineering Pusan National University

• Sung Mi-kyung

  Department Of Food And Nutrition Sookmyung Women's University

• Park Mi-young

  Department Of Food And Nutrition Sookmyung Women's University

• KWON Hoon-Jeong

  Department of Food and Nutrition, Seoul National University

• Kwon Hoon-jeong

  Department Of Food And Nutrition Seoul National University

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