Effects of High Cholesterol Diet on Newly Generated Cells in the Dentate Gyrus of C57BL/6N and C3H/HeN Mice
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概要
- 論文の詳細を見る
In this study, we observed and compared the effects of a high cholesterol diet (HCD) on cell proliferation and differentiation in the subgranular zone of the dentate gyrus of C57BL/6N (B6, susceptible strain) and C3H/HeN (C3H, resistant strain) mice. Ki67 (a marker for cell proliferation) positive cells) were significantly decreased in HCD-fed B6 mice compared to those in B6 (49.7%) and C3H mice fed a low cholesterol diet (LCD). In addition, doublecortin (DCX, a marker for cell differentiation or neuroblasts)-immunoreactive cells in HCD-fed B6 mice were significantly decreased compared to those in LCD-fed B6 and C3H mice. These results suggest that B6 strains are sensitive to HCD, which impairs cell proliferation and differentiation.
- 社団法人 日本獣医学会の論文
著者
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HWANG In
Department of Anatomy and Cell Biology, College of Veterinary Medicine and BK21 Program for Veterina
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YOO Ki-Yeon
Department of Anatomy and Neurobiology, College of Medicine, Hallym University
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YI Sun
Department of Anatomy and Cell Biology, College of Veterinary Medicine and BK21 Program for Veterina
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SEONG Je
Department of Anatomy and Cell Biology, College of Veterinary Medicine and BK21 Program for Veterina
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LEE In
Department of Anatomy and Cell Biology, College of Veterinary Medicine and BK21 Program for Veterina
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YOON Yeo
Department of Anatomy and Cell Biology, College of Veterinary Medicine and BK21 Program for Veterina
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WON Moo-Ho
Department of Anatomy and Neurobiology, College of Medicine, Hallym University
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Seong Je
Department Of Anatomy And Cell Biology College Of Veterinary Medicine And Bk21 Program For Veterinar
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KIM Il
Department of Radiation Oncology, Seoul National University College of Medicine
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Hwang In-koo
Department Of Anatomy And Cell Biology College Of Veterinary Medicine And Bk21 Program For Veterinar
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Yoo Ki-yeon
Department Of Anatomy College Of Medicine Hallym University
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Kim Yo
Department Of Anatomy And Cell Biology College Of Veterinary Medicine And Bk21 Program For Veterinar
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Hwang In
Department Of Anatomy And Cell Biology College Of Veterinary Medicine And Bk21 Program For Veterinar
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Yoon Yeo
Department Of Anatomy And Cell Biology College Of Veterinary Medicine And Bk21 Program For Veterinar
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Yi Sun
Department Of Anatomy And Cell Biology College Of Veterinary Medicine And Bk21 Program For Veterinar
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Choi Ji
Department Of Pharmacology College Of Pharmacy Seoul National University
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Yoo Ki‐yeon
Hallym Univ. Chuncheon
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Kim Il
Department Of Anatomy And Cell Biology College Of Veterinary Medicine And Bk21 Program For Veterinar
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Choi Ji
Department Of Cardiology College Of Medicine Catholic University Of Daegu
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Lee In
Department Of Agronomy College Of Agriculture And Life Sciences Kyungpook National University
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Lee In
Department Of Aerospace Engineering
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Yoo Ki-yeon
Department Of Anatomy And Cell Biology College Of Veterinary Medicine And Bk21 Program For Veterinar
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Lee In
Department of Anatomy and Cell Biology, College of Veterinary Medicine and BK21 Program for Veterinary Science, Seoul National University
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WON Moo-Ho
Department of Anatomy and Neurobiology, and Institute of Neurodegeneration and Neuroregeneration, College of Medicine, Hallym University
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SEONG Je
Department of Anatomy and Cell Biology, College of Veterinary Medicine and BK21 Program for Veterinary Science, Seoul National University
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KIM Yo
Department of Anatomy and Cell Biology, College of Veterinary Medicine and BK21 Program for Veterinary Science, Seoul National University
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CHOI Ji
Department of Anatomy and Cell Biology, College of Veterinary Medicine and BK21 Program for Veterinary Science, Seoul National University
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