Ischemia-Related Changes in Galanin Expression in the Dentate Hilar Region after Transient Forebrain Ischemia in Gerbils
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概要
- 論文の詳細を見る
Although galanin (GAL) protects hippocampal neurons from ischemic damage, no study has examined ischemia-related changes in endogenous GAL in the hippocampal dentate gyrus. We investigated the chronological changes of GAL, well-known as the potassium channel opener, expression in the dentate gyrus at various times after 5 min of transient forebrain ischemia in gerbils. A few GAL-immunoreactive (IR) neurons were found in the polymorphic layer of the sham-operated group. Three hours after ischemia-reperfusion, the pattern of GAL immunoreactivity was similar to that of the sham-operated group and the number of GAL-IR neurons and immunoreactivity were highest 12 h after ischemic insult. At this time, GAL-IR neurons in the polymorphic layer showed strong GAL immunoreactivity. Thereafter, GAL-IR neurons and immunoreactivity significantly decreased in the dentate hilar region. Four days after ischemic insult, GAL-IR neurons were not detectable. In addition, the results of a Western blot study showed a pattern of GAL expression similar to the immunohistochemical changes. GAL protein content also was highest 12 h after ischemia. In conclusion, the increased expression of endogenous GAL in the dentate gyrus after ischemia is related to response to the ischemic damage.
- 社団法人 日本実験動物学会の論文
- 2005-01-01
著者
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Kim Jong
School of Applied Chemical Engineering & The Institute for Catalysis Research, Chonnam National Univ
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HWANG In
Department of Anatomy and Cell Biology, College of Veterinary Medicine and BK21 Program for Veterina
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Won Moo
Department Of Anatomy And Neurobiology College Of Medicine Hallym University:institute Of Neurodegen
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Hwang In-koo
Department Of Anatomy And Cell Biology College Of Veterinary Medicine And Bk21 Program For Veterinar
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KANG Tae-Cheon
Department of Anatomy, College of Medicine, Hallym University
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Hwang In
韓国
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Kang Tae-cheon
Department Of Anatomy College Of Medicine Hallym University
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Kim Jong
Department Of Surgery College Of Medicine Hallym University
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Hwang In
Department Of Anatomy And Cell Biology College Of Veterinary Medicine And Bk21 Program For Veterinar
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Lee Bong-hee
Institute For Systems Medicine Gil Medical Center Gachon University Of Medicine And Science
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Lee Bong-hee
韓国
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LIM Beong
Department of Life Science, Konkuk University
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Lim B
Department Of Life Science Konkuk University
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Lim Beong
Department Of Applied Biochemistry Konkuk University
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Lim Beong
Laboratory Of Food Science Department Of Food Science And Technology Faculty Of Agriculture 46-09 Ky
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Kim Dae
School Of Electrical Engineering And Inter-university Semiconductor Research Center(isrc) Seoul Nati
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KIM Chang
School of Biological Sciences, Seoul National University
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LEE Hyeon
School of Biotechnology and Bioengineering, Kangwon National University
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Lim Beong
Department Of Life Science Konkuk University
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KIM Jung
School of Life Science and Biotechnology, Division of Life Science, Korea University
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BANG Kyung
National Institute of Crop Science
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SEONG Nak
National Institute of Crop Science
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LEE Hak
Forest Research Institute
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Lee Hak
Division Of Wood Chemistry & Microbiology Korea Forest Research Institute
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Seong Nak
Crop Experiment Station
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Kim Chang
School Of Biotechnology And Bioengineering Kangwon National University
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Lee H
College Of Bioscience And Biotechnology Department Of Biomaterials Engineering Kangwon National Univ
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Lim B
Institute For Systems Medicine Gil Medical Center Gachon University Of Medicine And Science
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Kim Dae
School Of Biotechnology And Bioengineering Kangwon National University
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Kim Jung
School Of Electrical Engineering And Inmc Seoul National University
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Hwang In
Department of Anatomy and Cell Biology, College of Veterinary Medicine and BK21 Program for Veterinary Science, Seoul National University
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Kim Jung
School of Chemical Engineering and Biotechnology, Yonsei University
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