The Essential Oil from Angelica gigas NAKAI Suppresses Nicotine Sensitization(Pharmacology)

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概要

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• Behavioral sensitization, as evidenced by the progressive enhanced locomotor response to a subsequent injection of the drug, is the major behavioral outcome produced by repeated injections of nicotine, and a model for studying drug addiction. It is putatively regarded that the alteration of extracellular dopamine release in the nucleus accumbens is closely associated with nicotine-induced behavioral sensitization. The present study was performed to evaluate the effects of the essential oil from Angelica gigas NAKAI (on fragrance inhalation) on repeated nicotine-induced locomotor activity and extracellular dopamine levels in the nucleus accumbens of rats using in vivo microdialysis. Rats were given repeated injections of saline or nicotine (0.4mg/kg s.c., twice a day for 7d), followed by one challenge injection on the 4th day after the last daily injection. Systemic challenge with nicotine (0.4mg/kg s.c.) produced a larger increase in locomotor activity in nicotine-pretreated rats than in saline-pretreated rats. A direct local challenge of 3mM nicotine via a microdialysis probe also induced a larger increase in dopamine release in nicotine-pretreated rats than in saline-pretreated rats. Most importantly, our results showed that inhalation of the essential oils from Angelica gigas NAKAI significantly decreased both dopamine release in the nucleus accumbens and locomotor activity induced by a nicotine challenge. These results suggest that the essential oils from Angelica gigas NAKAI inhibit nicotine-induced behavioral and neurochemical sensitization, and imply that the essential oil from Angelica gigas NAKAI may be effective in treating nicotine addiction, possibly by modulating dopamine release in the nucleus accumbens.

• 公益社団法人日本薬学会の論文
• 2005-12-01

著者

• Yang Chae

  The Research Center For Biomedical Resources Of Oriental Medicine Daegu Haany University:college Of

• Zhao Rong

  The Research Center For Biomedical Resources Of Oriental Medicine Daegu Haany University

• Shim Insop

  College Of Medicine The Catholic University Of Korea

• Kim Dae

  School Of Electrical Engineering And Inter-university Semiconductor Research Center(isrc) Seoul Nati

• Kim Dae

  School Of Medicine Keimyung University

• Koo Byung

  College Of Oriental Medicine Dongguk University

• Jang Eun

  The Research Center For Biomedical Resources Of Oriental Medicine Daegu Haany University

• Kwon Young

  College Of Oriental Medicine Daegu Haany University

• KIM Geun

  College of Oriental Medicine, Dongguk University

• LEE Jong

  The Research Center for Biomedical Resources of Oriental Medicine, Daegu Haany University

• KIM Mi

  The Research Center for Biomedical Resources of Oriental Medicine, Daegu Haany University

• KIM Sang

  The Research Center for Biomedical Resources of Oriental Medicine, Daegu Haany University

• KIM Kwang

  College of Oriental Medicine, Daegu Haany University

• HUH Tae

  TG Biotech Co. Ltd. Techno Building, Kyungpook National University

• Huh Tae

  Tg Biotech Co. Ltd. Techno Building Kyungpook National University

• Kim Kwang

  College Of Oriental Medicine Daegu Haany University

• Kim Kwang

  College Of Agriculture And Life Sciences Seoul National University

• Kim Dae

  School Of Biotechnology And Bioengineering Kangwon National University

• Kim Sang

  The Research Center For Biomedical Resources Of Oriental Medicine Daegu Haany University:college Of

• Kim Geun

  College Of Oriental Medicine Dongguk University

• Kim Mi

  The Research Center For Biomedical Resources Of Oriental Medicine Daegu Haany University:college Of

• Lee Jong

  The Research Center For Biomedical Resource Of Oriental Medicine Daegu Haany University

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