Immunohistochemical Changes in Orexigenic and Anorexigenic Neuropeptides in the Rat Hypothalamus after Capsaicin Administration
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概要
- 論文の詳細を見る
Capsaicin has effects on the adiposity by increasing energy and lipid metabolism, and decreases appetite and fat intake. In the present study, we investigated changes in food intake and body weight after capsaicin treatment. We also observed changes in orexigenic and anorexigenic neuropeptides-agouti-related peptide (AgRP), α-melanocyte-stimulating hormone (α-MSH), adrenocorticotropic hormone (ACTH) and orexin-immunoreactivities in the rat hypothalamus after capsaicin administration. Only one day after capsaicin treatment, the mean food intake was significantly decreased. There was no significant difference in the mean body weight between vehicle- and capsaicin-treated groups. In addition, after capsaicin treatment, numbers of AgRP- and orexin-immunoreactive (+) cells were significantly decreased in the arcuate nucleus (ARC) and lateral hypothalamic area, respectively. In contrast, the number of α-MSH+ and ACTH+ cells in the ARC of the capsaicin-treated rats was higher than in the vehicle-treated rats. These results indicate that capsaicin reduces food intake, not body weight, transiently, and decreases AgRP and orexin immunoreactivities, whereas it increases α-MSH and ACTH immunoreactivities in rat hypothalamic nuclei.
- 社団法人 日本獣医学会の論文
著者
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HWANG In
Department of Anatomy and Cell Biology, College of Veterinary Medicine and BK21 Program for Veterina
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CHOI Jung
Department of Anatomy and Neurobiology, College of Medicine, Hallym University
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LI Hua
Department of Anatomy and Neurobiology, College of Medicine, Hallym University
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YOO Ki-Yeon
Department of Anatomy and Neurobiology, College of Medicine, Hallym University
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LEE Choong
Department of Anatomy and Cell Biology, College of Veterinary Medicine and BK21 Program for Veterina
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WON Moo-Ho
Department of Anatomy and Neurobiology, College of Medicine, Hallym University
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Hwang In-koo
Department Of Anatomy And Cell Biology College Of Veterinary Medicine And Bk21 Program For Veterinar
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Hwang In
Department Of Anatomy And Cell Biology College Of Veterinary Medicine And Bk21 Program For Veterinar
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Park Ok
Department Of Anatomy And Neurobiology College Of Medicine Hallym University
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Lee Choong
Department Of Anatomy And Cell Biology College Of Veterinary Medicine And Bk21 Program For Veterinar
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Choi Jung
Department Of Anatomy And Neurobiology College Of Medicine Hallym University
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SHIN Hyung-Cheul
Department of Physiology, College of Medicine, Hallym University
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YAN Bingchun
Department of Anatomy and Neurobiology, and Institute of Neurodegeneration and Neuroregeneration, Co
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Yoo Ki-yeon
Department Of Anatomy And Cell Biology College Of Veterinary Medicine And Bk21 Program For Veterinar
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Choi Jung
Department Of Agricultural Biotechnology Seoul National University
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LEE Choong
Department of Anatomy and Neurobiology, and Institute of Neurodegeneration and Neuroregeneration, College of Medicine, Hallym University
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Hwang In
Department of Anatomy and Cell Biology, College of Veterinary Medicine and BK21 Program for Veterinary Science, Seoul National University
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WON Moo-Ho
Department of Anatomy and Neurobiology, and Institute of Neurodegeneration and Neuroregeneration, College of Medicine, Hallym University
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CHOI Jung
Department of Anatomy and Neurobiology, and Institute of Neurodegeneration and Neuroregeneration, College of Medicine, Hallym University
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YAN Bingchun
Department of Anatomy and Neurobiology, and Institute of Neurodegeneration and Neuroregeneration, College of Medicine, Hallym University
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PARK Ok
Department of Anatomy and Neurobiology, and Institute of Neurodegeneration and Neuroregeneration, College of Medicine, Hallym University
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LI Hua
Department of Anatomy and Neurobiology, and Institute of Neurodegeneration and Neuroregeneration, College of Medicine, Hallym University
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