Inhibition of IL-8 Production by Green Tea Polyphenols in Human Nasal Fibroblasts and A549 Epithelial Cells(Pharmacology)

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概要

• 論文の詳細を見る

• The attraction of leukocytes to tissues is essential in order for inflammation and the host response to infection to occur. Airway inflammation is a very common cause illness with a substantial impact on health care. Neutrophils play an essential role in the host defense and in inflammation, but the latter may trigger and sustain the pathogenesis of a range of acute and chronic diseases. Infiltration of neutrophils occurs as a response to chemoat-tractant molecules by resident tissue cells. The recruitment of neutrophils in airway inflammation may account for the generation of IL-8. To evaluate the effectiveness of green tea polyphenols in the modulation of airway inflammation through the blocking of neutrophil chemokine production, nasal mucosal fibroblasts and A549 bronchial epithelial cells were analyzed for the production of IL-8. Both nasal mucosal fibroblasts and bronchial epithelial cells produced significant amounts of IL-8 through stimulation of IL-1β. Tea polyphenols were very effective in the inhibition of IL-8 production. Among the polyphenols tested, EGCG and ECG showed strong inhibitory activity in dose-dependent manners. EGC and EC showed moderate inhibition at 48h culture, whereas (-) catechin was not effective. Production of IL-8 after stimulation by proinflammatory cytokines in both nasal fibroblasts and bronchial epithelial cells was significantly blocked by pretreatment with green tea polyphenols.

• 公益社団法人日本薬学会の論文
• 2006-06-01

著者

• LI Hua

  Department of Anatomy and Neurobiology, College of Medicine, Hallym University

• PARK Cheung-Seog

  Department of Oncology, Osaka University Graduate School of Medicine

• Cho Jeong

  Department Of Microbiology (bk21) College Of Medicine Kyung Hee University:kohwang Medical Research

• Cho Jeong-je

  韓国

• Park Cheung

  Department Of Microbiology (bk21) College Of Medicine Kyung Hee University:kohwang Medical Research

• LEE Su-Jin

  Department of Microbiology (BK21), College of Medicine, Kyung Hee University

• CHO Jeong-Je

  Department of Microbiology (BK21), College of Medicine, Kyung Hee University

• Park Cheung-seog

  Department Of Microbiology College Of Medicine Kyung Hee University

• KIM In-Bae

  Department of Microbiology, College of Medicine, Kyung Hee University

• KIM Dong-Young

  Department of Microbiology, College of Medicine, Kyung Hee University

• SUN Min-Jung

  Department of Microbiology, College of Medicine, Kyung Hee University

• LEE Myung-Sook

  Department of Microbiology, College of Medicine, Kyung Hee University

• Kim In-bae

  Department Of Microbiology College Of Medicine Kyung Hee University

• Lee Su-jin

  Department Of Microbiology (bk21) College Of Medicine Kyung Hee University

• Sun Min-jung

  Department Of Microbiology College Of Medicine Kyung Hee University

• Cho Jeong-je

  Department Of Microbiology College Of Medicine Kyung Hee University

• Kim Dong-young

  Department Of Microbiology College Of Medicine Kyung Hee University

• Lee Myung-sook

  Department Of Microbiology College Of Medicine Kyung Hee University

• Kim In-bae

  Department Of Material Science & Engineering Pusan National University

• Li Hua

  Department Of Microbiology College Of Medicine Kyung Hee University

• Lee Su-jin

  Department Of Medical Genetics School Of Medicine Ajou University

• LI Hua

  Department of Anatomy and Neurobiology, and Institute of Neurodegeneration and Neuroregeneration, College of Medicine, Hallym University

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