Oral Administration of Astragalus membranaceus Inhibits the Development of DNFB-Induced Dermatitis in NC/Nga Mice(Pharmacology)
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概要
- 論文の詳細を見る
Epicutaneously administered chemical antigens like 2,4-dinitrofluorobenzene (DNFB), evoke an atopic dermatitis (AD)-like dermatitis reaction in NC/Nga mice under specific pathogen free (SPF) conditions. Astragalus membranaceus (AM), is a popular herbal medicine used to treat allergic diseases in East Asia. In the present study, we examined whether AM suppress AD-like skin lesions in NC/Nga mice treated with DNFB under SPF conditions. Oral administration of AM to DNFB-treated NC/Nga mice was found to inhibit ear thickness increases and the skin lesions induced by DNFB. Moreover, IFN-γ production by CD4^+ T cells from the lymph nodes of DNFB-treated NC/Nga mice was significantly inhibited by AM treatment, although levels of IL-4 and total IgE in serum were not. Study findings suggest that AM may suppress the development of AD-like dermatitis in DNFB-treated NC/Nga mice by reducing IFN-γ production.
- 社団法人日本薬学会の論文
- 2007-08-01
著者
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PARK Cheung-Seog
Department of Oncology, Osaka University Graduate School of Medicine
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Cho Jeong
Department Of Microbiology (bk21) College Of Medicine Kyung Hee University:kohwang Medical Research
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Cho Jeong-je
韓国
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SEO Sang-Wan
Department of Pharmacology, College of Oriental Medicine, Kyung Hee University
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Ahn Hyun
Department Of Microbiology (bk21) College Of Medicine Kyung Hee University:kohwang Medical Research
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Park Cheung
Department Of Microbiology (bk21) College Of Medicine Kyung Hee University:kohwang Medical Research
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Seo S‐b
Department Of Pharmacology College Of Oriental Medicine Kyung Hee University:department Of Oriental
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Seo Sang
Department Of Herbology College Of Oriental Medicine Wonkwang University
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LEE Su-Jin
Department of Microbiology (BK21), College of Medicine, Kyung Hee University
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OH Seung-Geun
Department of Microbiology (BK21), College of Medicine, Kyung Hee University
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AHN Hyun-Jong
Department of Microbiology (BK21), College of Medicine, Kyung Hee University
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GEUM Dongho
Graduate School of Medicine, Korea University
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CHO Jeong-Je
Department of Microbiology (BK21), College of Medicine, Kyung Hee University
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Park Cheung-seog
Department Of Microbiology College Of Medicine Kyung Hee University
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Oh Seung-geun
Department Of Microbiology (bk21) College Of Medicine Kyung Hee University
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Lee Su-jin
Department Of Microbiology (bk21) College Of Medicine Kyung Hee University
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Geum Dongho
Graduate School Of Medicine Korea University
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Cho Jeong-je
Department Of Microbiology College Of Medicine Kyung Hee University
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Lee Su-jin
Department Of Medical Genetics School Of Medicine Ajou University
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Seo Sang-Wan
Department of Herbology, College of Oriental Medicine, Wonkwang University
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