Histone Deacetylase 1 Contributes to Cell Cycle and Apoptosis(Molecular and Cell Biology)
スポンサーリンク
概要
- 論文の詳細を見る
Histone deacetylases (HDACs) are generally thought to play important roles in human disease. However, little information is available concerning the specific functions of individual HDACs. We previously reported on transgenic mice that expressed human HDAC1 and experienced steatosis and nuclear pleomorphism in their hepatic tissues. To find out if the over-expression of HDAC1 contributes to the expression of genes related to the cell cycle, apoptosis, and lipid metabolism that eventually contribute to the pathological changes in the livers of the transgenic mice, the expression profiles of the related genes in liver tissues were determined by reverse transcription-polymerase chain reaction (RT-PCR) and Western blot analysis. The activated human HDAC1 significantly induced the expression levels of mRNA for p53, PPAR-gamma and Bak and reduced the p21 expression level compared with the levels in control littermates. However, the protein levels of p53 and PPAR-gamma were significantly decreased. In conclusion, our results indicate that HDAC1 can regulate gene expression at the mRNA and protein levels independently and that this may be a potential cytopathic factor for hepatic tissue in transgenic mice that over-express HDAC1.
- 公益社団法人日本薬学会の論文
- 2005-10-01
著者
-
KIM Sang
College of Veterinary Medicine, Chungnam National University
-
Lee Dong-seok
韓国
-
Lee Sang
School Of Life Sciences And Biotechnology Korea University
-
Kim Sang
College Of Pharmacy Seoul National University
-
Kim Sun
Laboratory Medicine, Gyeongsang National University Hospital, Korea
-
Seo Sang
Department Of Herbology College Of Oriental Medicine Wonkwang University
-
KIM Sun-Uk
Laboratory of Human Genomics
-
Kim Sun-uk
School Of Life Sciences And Biotechnology Korea University:disease Model Research Center Biological
-
Kim Sun
Laboratory Of Human Genomics Korea Research Institute Of Bioscience And Biotechnology (kribb):labora
-
Yu Dae-yeul
Disease Model Research Center Biological Resource Center Kribb
-
Yu Dae
Laboratory Of Human Genomics Korea Research Institute Of Bioscience And Biotechnology (kribb)
-
Lee Sang-ho
韓国
-
Seo Sang
Department Of Life Science College Of Natural Sciences Chung-ang University
-
WANG Ai
Laboratory of Human Genomics, Korea Research Institute of Bioscience and Biotechnology (KRIBB)
-
LEE Sang
Laboratory of Reproductive and Developmental Biology, School of Life Sciences and Biotechnology, Kor
-
LEE Dong
Laboratory of Human Genomics, Korea Research Institute of Bioscience and Biotechnology (KRIBB)
-
Wang Ai
Laboratory Of Human Genomics Korea Research Institute Of Bioscience And Biotechnology (kribb):colleg
-
Lee Dong
Laboratory Of Human Genomics Korea Research Institute Of Bioscience And Biotechnology (kribb)
-
Kim Sun
Laboratory For Quantum Optics Korea Atomic Energy Research Institute
-
Wang Ai-Guo
Laboratory of Human Genomics, Korea Research Institute of Bioscience and Biotechnology (KRIBB):College of Veterinary Medicine, Chungnam National University
-
SEO Sang
Department of Hematology/Oncology, Kyungpook National University Hospital, Kyungpook National University School of Medicine
関連論文
- Characterization and Identification of Erysipelothrix rhusiopathiae Isolated from Unnatural Host, a Cat, with a Clinical Manifestation of Depression
- Intussusception in a Young Female with Vibrio Gastroenteritis and Diabetic Ketoacidosis
- Immune-Enhancing Effect of the Korean Natural Medicine WooKiEum(Pharmacology)
- The Immune-Enhancing Effect of the Herbal Combination Bouum-Myunyuk-Dan(Pharmacology)
- Nicotinamide Adenine Dinucleotide Phosphate (NADPH) Oxidase-Dependent Activation of Phosphoinositide 3-Kinase and p38 Mitogen-Activated Protein Kinase Signal Pathways Is Required for Lipopolysaccharide-Induced Microglial Phagocytosis(Molecular and Cell Bi
- Peroxiredoxin I Is an Indicator of Microglia Activation and Protects against Hydrogen Peroxide-Mediated Microglial Death(Molecular and Cell Biology)
- Inhibitory Effect of High Molecular Weight Water-Soluble Chitosan on Hypoxia-Induced Inflammatory Cytokine Production
- Oral Administration of Astragalus membranaceus Inhibits the Development of DNFB-Induced Dermatitis in NC/Nga Mice(Pharmacology)
- The 3-Hydroxy-3-methylglutaryl Coenzyme A (HMG-CoA) Reductase Inhibitor, Lovastatin (Statin) Ameliorates CCK-Induced Acute Pancreatitis in Rats(Pharmacology)
- Effective Production of Microinjectable Blastocysts for Germ-Line Transmission of Embryonic Stem Cells
- Dual Anti-oxidative Effects of Fraxetin Isolated from Fraxinus rhinchophylla
- SB-P4 Synthesis of post-transcriptional modulator for fine-tunable expression(Section XI Systems Biotechnology/Metabolic Engineering)
- Regional Climate Simulation for Korea using Dynamic Downscaling and Statistical Adjustment(Regional Climate Modeling for Monsoon System)
- Effect of Dimethyl-4,4'-dimethoxy-5,6,5', 6'-dimethylenedioxybiphenyl-2,2'-dicarboxylate (DDB) on Chemical-Induced Liver Injury
- Histone Deacetylase 1 Contributes to Cell Cycle and Apoptosis(Molecular and Cell Biology)
- Total Peroxynitrite Scavenging Capacity of Phenylethanoid and Flavonoid Glycosides from the Flowers of Buddleja officinalis
- Multi-Well Chip for Forming a Uniform Embryoid Body in a Tiny Droplet with Mouse Embryonic Stem Cells
- Prevalence of Lawsonia intracellularis, Salmonella spp. and Eimeria spp. in Healthy and Diarrheic Pet Rabbits
- Design of a Diode-Pumped Yb:YAG Rod Laser with High Efficiency by Using a Diffusive Optical Cavity
- Two CML patients who subsequently developed features of essential thrombocythemia with JAK2-V617F mutation while in complete cytogenetic remission after treatment with imatinib mesylate