Peroxiredoxin I Is an Indicator of Microglia Activation and Protects against Hydrogen Peroxide-Mediated Microglial Death(Molecular and Cell Biology)
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概要
- 論文の詳細を見る
Imbalance between oxidative stress and antioxidative defence system is generally known as one of mechanisms causing an oxidative stress-medicated neuropathogenesis. Peroxiredoxins (Prxs), a family of antioxidative enzymes neutralizing cellular hydroperoxides, was characterized recently, but their distributions and roles have not been resolved clearly or controversial in the central nervous system, Therefore, the present study was carried out to determine the specific cell types that express Prx I in the mouse brain and primary neural cells, and to examine its antioxidative role in the preferential cell types. Immunohistochemical reactivity for Prx I was detected dominantly in oligodendrocytes and rarely in microglia, whereas strong and specific immunoreactivity for Prx I was observed exclusively in microglia of primary neural cell culture. Further evidences for Prx I specificity were its relatively high expression in BV-2 microglial cells and its upregulated expression in microglia after lipopolysaccharide (LPS) stimulation. These results imply that Prx I can be used as an indicator of microglial activation. Inhibition of p38 MAPK ablated LPS-mediated Prx I upregulation and sensitized the microglia to H_2O_2-mediated cell death. These findings indicate that Prx I function as a scavenger for H_2O_2 generated during microglial activation. The results of this study will help in unraveling the neuropathologic roles of the six Prx isoforms in neural function.
- 社団法人日本薬学会の論文
- 2008-05-01
著者
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Lee Sang
School of Electronics & Telecommunication Engineering, Korea Aerospace University
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Han Ying-hao
Disease Model Research Center Biological Resource Center Kribb
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Han Ying-hao
韓国
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Lee Sang
School Of Life Sciences And Biotechnology Korea University
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Hwang Chang
School Of Life Sciences And Biotechnology Korea University
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Kim Jin-man
Department Of Pathology College Of Medicine Chungnam National University
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Kim Jin-man
Department Of Animal Science Kon-kuk University
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KIM Sang-Keun
College of Veterinary Medicine, Chungnam National University
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SUN Hu-Nan
Disease Model Research Center, Biological Resource Center, KRIBB
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YU Dae-Yeul
Disease Model Research Center, Biological Resource Center, KRIBB
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LEE Dong-Seok
College of Natural Sciences, Kyungpook National University
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KIM Sun-Uk
School of Life Sciences and Biotechnology, Korea University
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JIN Mei-Hua
Disease Model Research Center, Biological Resource Center, KRIBB
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LEE Hwang
School of Life Sciences and Biotechnology, Korea University
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Lee Dong-seok
College Of Natural Sciences Kyungpook National University
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Lee Hwang
School Of Eecs Kaist
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Lee Hwang
School Of Life Sciences And Biotechnology Korea University:national Veterinary Research And Quaranti
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Kim Sun-uk
School Of Life Sciences And Biotechnology Korea University:disease Model Research Center Biological
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Lee S.
School Of Life Sciences And Biotechnology Korea University
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Lee D‐s
College Of Natural Sciences Kyungpook National University
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Jin Mei-hua
Disease Model Research Center Biological Resource Center Kribb
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Sun Hu-nan
Disease Model Research Center Biological Resource Center Kribb:college Of Veterinary Medicine Chungn
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Kim Sun
Laboratory Of Human Genomics Korea Research Institute Of Bioscience And Biotechnology (kribb):labora
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Yu Dae-yeul
Disease Model Research Center Biological Resource Center Kribb
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Yu Dae
Laboratory Of Human Genomics Korea Research Institute Of Bioscience And Biotechnology (kribb)
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Lee Sang-ho
韓国
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Lee Sang
School Of Advanced Material Engineering Kookmin University
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Kim Sang-keun
College Of Veterinary Medicine Chungnam National University
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Hwang Chang-Nam
School of Life Sciences and Biotechnology, Korea University
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