Effects of Proteins from Hen Egg Yolk on Human Platelet Aggregation and Blood Coagulation(Pharmacology)
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概要
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We studied the effect on both platelet aggregation and blood coagulation, known to be major risk factors in thrombogenesis, of proteins from hen egg yolk (EP). EP potently inhibited collagen-induced human platelet aggregation in a dose-dependent manner. Furthermore, EP has a synergistic effect on the inhibition of human platelet aggregation with both molsidomine, an inhibitor of cGMP-specific phosphodiesterase, and theophylline, an inhibitor of cAMP-specific phosphodiesterase. These results indicate that the active mode of EP might be involved in elevation of the levels of both cGMP and cAMP. Prothrombin time and activated partial thromboplastin time were potently prolonged by EP. These data suggest that EP prolongs the time interval between the conversion of fibrinogen to fibrin. Accordingly, these findings demonstrate that EP might have antithrombotic effects by inhibiting platelet aggregation and fibrin formation.
- 社団法人日本薬学会の論文
- 2003-10-01
著者
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Cho Hyun
Department Of Biomedical Laboratory Science College Of Biomedical Science And Engineering And Region
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Cho Hyun-jeong
韓国
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Park Hee-juhn
Division Of Applied Plant Sciences Sangji University
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Cho Hyun-jeong
Department Of Biomedical Laboratory Science College Of Biomedical Science And Engineering Inje Unive
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Ham Hye-seon
Department Of Biomedical Laboratory Science College Of Biomedical Science And Engineering Inje Unive
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LEE Dong-Seok
Department of Biomedical Laboratory Science, College of Biomedical Science and Engineering, Inje Uni
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PARK Hwa-Jin
Department of Biomedical Laboratory Science, College of Biomedical Science and Engineering, Inje Uni
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LEE Dong-Seok
College of Natural Sciences, Kyungpook National University
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Lee Dong-seok
College Of Natural Sciences Kyungpook National University
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Lee D‐s
College Of Natural Sciences Kyungpook National University
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Park Hwa
Department Of Biomedical Laboratory Science College Of Biomedical Science And Engineering And Region
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Park Hwa-jin
Department Of Biochemical Pharmacology Korea Ginseng And Tobacco Research Institute
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Lee Dong-seok
Department Of Biomedical Laboratory Science College Of Biomedical Science And Engineering Inje Unive
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