Augmentation of Ca^<2+> -Induced Microsomal Triglyceride Transfer Protein Activity by Glucose Supply Enhances Hypertriglyceridemia in Vivo(Molecular and Cell Biology)
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概要
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We have investigated possible roles of intra-glucose supply on microsomal triglyceride (TG) transfer protein (MTP) in the secretion of TG-rich very low-density lipoprotein (VLDL) from the liver. Due to the activation of MTP, TG and apolipoprotein B (apoB) in the liver are assembled into VLDL and then the VLDL is transferred into the blood stream. High MTP activity can increase the release of VLDL into the blood stream, and this would lead high levels of TG and apoB in the blood. High MTP activity was found when the liver (or hepatocytes) contained a high level of total Ca^<2+> as a response of glucose administration. However, the MTP activity was reduced in response to the calmodulin antagonist N-(6-aminohexyl)-5-chloro-1-naphthalene sulfonamide (W-7, K_i=25μM), the intracellular Ca^<2+> chelator BAPTA-AM, and the extracellular Ca^<2+> chelator EDTA. These suggested that there might be a very close relationship between high MTP activity and high Ca^<2+> level in the liver by glucose administration. Glucose-derived hyperglycemic condition resulted from those elevations of TG and total cholesterol in the liver. This hyperglycemic phenomenon may be associated with the increase of TG and apoB levels in blood. The possibility for the regulation of VLDL formation in the liver and, further, those related circulatory diseases due to the excess of VLDL in the blood stream by controlling MTP activity in association with Ca^<2+> was investigated.
- 公益社団法人日本薬学会の論文
- 2006-05-01
著者
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Cho Hyun
Department Of Biomedical Laboratory Science College Of Biomedical Science And Engineering And Region
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Cho Hyun-jeong
韓国
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Cho Hyun-jeong
Department Of Biomedical Laboratory Science College Of Biomedical Science And Engineering Inje Unive
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Kim Hyeong-soo
Department Of Biomedical Laboratory Science College Of Biomedical Science And Engineering And Region
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PARK Hwa-Jin
Department of Biomedical Laboratory Science, College of Biomedical Science and Engineering, Inje Uni
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KANG Hyo-Chan
Department of Biomedical Laboratory Science, College of Biomedical Science and Engineering, Inje Uni
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Ju Young
Department Of Biomedical Laboratory Science College Of Biomedical Science And Engineering And Region
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Park Hwa
Department Of Biomedical Laboratory Science College Of Biomedical Science And Engineering And Region
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Park Hwa-jin
Department Of Biochemical Pharmacology Korea Ginseng And Tobacco Research Institute
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Kang Hyo
Department Of Biomedical Laboratory Science College Of Biomedical Science And Engineering And Region
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JU Young-Cheol
Department of Biomedical Laboratory Science, College of Biomedical Science and Engineering, and Regi
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LEE Hyun-Sub
Department of Biomedical Laboratory Science, College of Biomedical Science and Engineering, and Regi
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Lee Hyun
Department Of Biomedical Laboratory Science College Of Biomedical Science And Engineering And Region
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Kang Hyo-Chan
Department of Biomedical Laboratory Science, College of Biomedical Science and Engineering, and Regional Research Center, Inje University
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