Possible Role of Ginsenoside Rb_1 on Regulation of Rat Liver Triglycerides
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概要
- 論文の詳細を見る
We have studied the effects of ginsenoside Rb_1 (GRb_1) on the change in lipid contents in rat liver. When GRb_1 was administered intraperitoneally to rats, liver microsomal cytochrome P-450 content and NADPH-cy-tochrome P-450 reductase activity were lower than those in control rats. The contents of triglyceride (TG) and cholesterol were decreased, but those of total phospholipid, phosphatidylcholine, and phosphatidylethanolamine were increased in the GRb_1-treated group compared with controls. These results indicate that GRb_1 might be involved in lipid metabolism by regulating the activity of microsomal cytochrome P-450 monooxygenase. Although liver TG levels were reduced by GRb_1, the levels of TG and β-lipoprotein in serum from the GRb_1-treated group did not change as compared with those in controls. Thus we suggest that the decrease in liver TG levels with GRb_1-treatment is not associated with the secretion of TG-rich very low-density lipoprotein. Furthermore, the level of cAMP was also significantly increased in the GRb_1-treated group as compared with that in controls. Additionally, the cAMP level was more markedly increased as compared with that in the GRb_1-treated group or control group when GRb_1 was exogenously added to the reaction system for measuring cAMP production in homogenates from control group liver. Accordingly, these results demonstrate that GRb_1 might lower TG levels via cAMP-production in the liver, and GRb_1 might be an interesting candidate to for a modulator of cAMP-mediated effects, especially within the liver steatosis system.
- 社団法人日本薬学会の論文
- 2002-04-01
著者
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Cho Hyun
Department Of Biomedical Laboratory Science College Of Biomedical Science And Engineering And Region
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Cho Hyun-jeong
韓国
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Park Hee-juhn
Division Of Applied Plant Sciences Sangji University
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Park Kyeong-mee
Department Of Biochemical Pharmacology Korea Ginseng And Tobacco Research Institute
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Cho Hyun-jeong
Department Of Biomedical Laboratory Science College Of Biomedical Science And Engineering Inje Unive
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Song Y‐b
Department Of Biomedical Pharmacology Korea Ginseng And Tobacco Research Institute
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Ham Hye-seon
Department Of Biomedical Laboratory Science College Of Biomedical Science And Engineering Inje Unive
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PARK Hwa-Jin
Department of Biomedical Laboratory Science, College of Biomedical Science and Engineering, Inje Uni
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PARK Ki-Hyun
Department of Biomedical Pharmacology Korea Ginseng and Tobacco Research Institute
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SHIN Han-Jae
Department of Biomedical Pharmacology Korea Ginseng and Tobacco Research Institute
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SONG Young-Bum
Department of Biomedical Pharmacology Korea Ginseng and Tobacco Research Institute
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HYUN Hak-Chul
Department of Biomedical Pharmacology Korea Ginseng and Tobacco Research Institute
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YOO Young-Bin
Department of Biomedical Laboratory Science, College of Biomedical Science and Engineering, Inje Uni
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Ko Young-Chul
Department of Biomedical Laboratory Science, College of Biomedical Science and Engineering, Inje Uni
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JUN Woong-Tak
Department of Biomedical Laboratory Science, College of Biomedical Science and Engineering, Inje Uni
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Song Yong-bum
Department Of Biochemical Pharmacology Korea Ginseng And Tobacco Research Institute
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Yoo Young-bin
Department Of Biomedical Laboratory Science College Of Biomedical Science And Engineering Inje Unive
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Ko Young-chul
Materials & Devices Lab. Samsung Advanced Institute Of Technology
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Park Hwa
Department Of Biomedical Laboratory Science College Of Biomedical Science And Engineering And Region
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Park Hwa-jin
Department Of Biochemical Pharmacology Korea Ginseng And Tobacco Research Institute
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Ko Young-chul
Department Of Biomedical Laboratory Science College Of Biomedical Science And Engineering Inje Unive
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Jun Woong-tak
Department Of Biomedical Laboratory Science College Of Biomedical Science And Engineering Inje Unive
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