Saucernetin-8 Isolated from Saururus chinensis Induced the Differentiation of Human Acute Promyelocytic Leukemia HL-60 Cells(Pharmacognosy)
スポンサーリンク
概要
- 論文の詳細を見る
The present work was performed to investigate the effects of saucernetin-8 on proliferation and differentiation of human leukemia HL-60 cells as well as the underlying mechanisms for these effects. Saucernetin-8 exhibited a potent antiproliferative activity against HL-60 cells. This compound was also found to be a potent inducer of differentiation in human leukemia derived HL-60 cells through the examination of differentiation markers, as assessed by nitroblue tetrazolium reduction test, esterase activity assay, phagocytic activity assay, morphology change, and expression of CD14 and CD66b surface antigens. These results suggest that saucernetin-8 induces the differentiation of human leukemia cells to granulocytes and monocytes/macrophages lineage. Moreover, DNA flow-cytometry indicated that saucernetin-8 induced a G_1 phase arrest of HL-60 cells. The protein and mRNA expression levels of p21 were up-regulated during saucernetin-8-dependent HL-60 cell differentiation, whereas the level of c-myc was down-regulated. Taken together, our results suggest that saucernetin-8 may have potential as a therapeutic agent in human leukemia.
- 社団法人日本薬学会の論文
- 2004-10-01
著者
-
PARK Hee-Juhn
Division of Applied Plant Sciences, Sang-Ji University
-
LEE Kyung-Tae
College of Pharmacy, Kyung-Hee University
-
CHOI Jong-Won
College of Pharmacy, Kyung-Sung University
-
Choi Jongwon
Coll. Of Pharmacy Kyungsung Univ.
-
Choi Jong-won
韓国
-
Choi Jong-won
College Of Pharmacy Kyung-sung University
-
Lee Kyung-tae
韓国
-
Lee Kyung-tae
College Of Pharmacy Kyung-hee University
-
Lee Kyung-tae
Coll. Of Pharmacy Kyung-hee Univerisity
-
Lee Kyung-tae
Department Of Life And Nanopharmaceutical Sciences College Of Pharmacy Kyung Hee University
-
Lee Kyung-tae
Coll. Of Medical Sci. Kyung Hee Univ.
-
Lee Kyung-tae
Department Of Biochemistry College Of Pharmacy Kyung Hee University
-
Park Hee-juhn
Department Of Pharmaceutical Engineering Sangji University
-
Park Hee-juhn
韓国
-
Park Hee-juhn
Division Of Applied Plant Sciences Sangji University
-
Park Hee-juhn
Department Of Botanical Resources Sangi University
-
Shin Kyung-min
College Of Pharmacy Kyung-hee University
-
Shin Kyung-min
韓国
-
CHOI Seung-Ki
Department of Pharmacology, College of Medicine, Pochon Cha University
-
SEO Bo-Rim
College of Pharmacy Kyung-Hee University
-
YOO Chae-Bin
College of Pharmacy Kyung-Hee University
-
SEO Kyungwon
Toxicology Department, National Institute of Toxicological Research, Korea Food and Drug Administrat
-
Seo Bo-rim
Department Of Pharmaceutical Biochemistry And Kyung-hee East-west Pharmaceutical Research Institute
-
Seo Bo-rim
韓国
-
Yoo Chae-bin
韓国
-
Lee Kyung
College Of Pharmacy Kyung Hee University
-
Lee Kyung-won
韓国
-
Lee Kyung‐won
Kyung Hee Univ. Seoul Kor
-
Choi Seung-ki
韓国
-
Choi Seung-ki
Department Of Pharmacology College Of Medicine Pochon Cha University
-
Shin Kyung-min
Toxicology Department National Institute Of Toxicological Research Korea Food And Drug Administratio
-
Choi Jong-won
Coll. Of Pharmacy Kyungsung Univ.
-
Choi Jung-hye
Department Of Internal Medicine Hanyang University
-
Park Hee-joun
Department Of Botanical Resources Sangji University
-
Choi Jung-hye
Dep. Of Oriental Pharmaceutical Sci. Coll. Of Pharmacy Kyung Hee Univ.
-
Choi Jeongeun
College Of Pharmacy Kyungsung University
-
Seo Kyungwon
Toxicology Department National Institute Of Toxicological Research Korea Food And Drug Administratio
-
Choi Seung-ki
Medical Sci. And Engineering Res. Center For Bioreaction To Reactive Oxygen Species School Of Medici
関連論文
- Donepezil, a Potent Acetylcholinesterase Inhibitor, Induces Caspase-Dependent Apoptosis in Human Promyelocytic Leukemia HL-60 Cells
- 3α,23-Isopropylidenedioxyolean-12-en-27-oic Acid, a Triterpene Isolated from Aceriphyllum rossii, Induces Apoptosis in Human Cervical Cancer HeLa Cells through Mitochondrial Dysfunction and Endoplasmic Reticulum Stress
- Taraxinic Acid, a Hydrolysate of Sesquiterpene Lactone Glycoside from the Taraxacum coreanum NAKAI, Induces the Differentiation of Human Acute Promyelocytic Leukemia HL-60 Cells
- Metabolism of Kalopanaxsaponin K by Human Intestinal Bacteria and Antirheumatoid Arthritis Activity of Their Metabolites
- Metabolism of 6"-O-Xylosyltectoridin and Tectoridin by Human Intestinal Bacteria and Their Hypoglycemic and in Vitro Cytotoxic Activities
- Metabolism of Kalopanaxsaponin B and H by Human Intestinal Bacteria and Antidiabetic Activity of Their Metabolites
- Preventive Effect of Ginkgo biloba Extract (GBB) on the Lipopolysaccharide-Induced Expressions of Inducible Nitric Oxide Synthase and Cyclooxygenase-2 via Suppression of Nuclear Factor-κB in RAW 264.7 Cells(Pharmacognosy)
- The Anti-gastropathic and Anti-rheumatic Effect of Niga-ichigoside F_1 and 23-Hydroxytormentic Acid Isolated from the Unripe Fruits of Rubus coreanus in a Rat Model(Pharmacognosy)
- β-D-Xylopyranosyl-(1→3)-β-D-glucuronopyranosyl Echinocystic Acid Isolated from the Roots of Codonopsis lanceolata Induces Caspase-Dependent Apoptosis in Human Acute Promyelocytic Leukemia HL-60 Cells(Pharmacognosy)
- 19α-Hydroxyursane-Type Triterpenoids : Antinociceptive Anti-inflammatory Principles of the Roots of Rosa rugosa(Pharmacognosy)
- Methanol Extract of Xanthium strumarium L. Possesses Anti-inflammatory and Anti-nociceptive Activities(Pharmacognosy)
- Saucernetin-8 Isolated from Saururus chinensis Induced the Differentiation of Human Acute Promyelocytic Leukemia HL-60 Cells(Pharmacognosy)
- Anti-inflammatory and Anti-nociceptive Effects of the Methanol Extract of Fomes fomentarius(Pharmacognosy)
- Structure-Activity Relationship of Oleanane Disaccharides Isolated from Akebia quinata versus Cytotoxicity against Cancer Cells and NO Inhibition (Pharmacognosy)
- Inhibition of Methanol Extract from the Fruits of Kochia scoparia on Lipopolysaccharide-Induced Nitric Oxide, Prostagladin E_2, and Tumor Necrosis Factor-α Production from Murine Macrophage RAW 264.7 Cells (Pharmacognosy)
- Antinociceptive and Antiinflammatory Effects of Niga-ichigoside F_1 and 23-Hydroxytormentic Acid Obtained from Rubus coreanus(Pharmacognosy)
- Inhibition of Methanol Extract from the Aerial Parts of Saururus chinensis on Lipopolysaccharide-Induced Nitric Oxide and Prostagladin E_2 Production from Murine Macrophage RAW 264.7 Cells
- Costunolide Triggers Apoptosis in Human Leukemia U937 Cells by Depleting Intracellular Thiols
- In Vitro Antiinflammatory Activity of Kalopanaxsaponin A Isolated from Kalopanax pictus in Murine Macrophage RAW 264.7 Cells
- Tectorigenin, an Isoflavone of Pueraria thunbergiana BENTH., Induces Differentiation and Apoptosis in Human Promyelocytic Leukemia HL-60 Cells
- Differentiation-Inducing Effect of Magnolialide, a 1β-Hydroxyeudesmanolide Isolated from Cichorium intybus, on Human Leukemia Cells
- Studies on Constituents with Cytotoxic Activity from the Stem Bark of Syringa velutina
- Inhibition of Lipopolysaccharide-Induced Expression of Inducible Nitric Oxide and Cyclooxygenase-2 by Chiisanoside via Suppression of Nuclear Factor-κB Activation in RAW 264.7 Macrophage Cells(Pharmacognosy)
- Antinociceptive Anti-inflammatory Effect of Monotropein Isolated from the Root of Morinda officinalis(Pharmacognosy)
- Isolation of Saponins with the Inhibitory Effect on Nitric Oxide, Prostaglandin E_2 and Tumor Necrosis Factor-α Production from Pleurospermum kamtschaticum(Pharmacognosy)
- A Cytotoxic and Apoptosis-Inducing Sesquiterpenoid Isolated from the Aerial Parts of Artemisia princeps PAMPANINI (Sajabalssuk)
- Protective Effect of the Ethanol Extract of the Roots of Brassica rapa on Cisplatin-Induced Nephrotoxicity in LLC-PK_1 Cells and Rats(Pharmacognosy)
- Induction of Apoptosis by Yomogin in Human Promyelocytic Leukemic HL-60 Cells(Pharmacognosy)
- Inhibition of LPS-Induced iNOS, COX-2 and Cytokines Expression by Poncirin through the NF-κB Inactivation in RAW 264.7 Macrophage Cells(Pharmacognosy)
- A New Flavanone Glycoside from the Dried Immature Fruits of Poncirus trifoliata
- Outcome of Adult Severe or Very Severe Aplastic Anemia Treated with Immunosuppressive Therapy Compared with Bone Marrow Transplantation : Multicenter Trial
- Effects of Proteins from Hen Egg Yolk on Human Platelet Aggregation and Blood Coagulation(Pharmacology)
- Possible Role of Ginsenoside Rb_1 on Regulation of Rat Liver Triglycerides
- The Seed Extract of Cassia obtusifolia Ameliorates Learning and Memory Impairments Induced by Scopolamine or Transient Cerebral Hypoperfusion in Mice
- Comparison of Microvessel Density before and after Peripheral Blood Stem Cell Transplantation in Multiple Myeloma Patients and Its Clinical Implications : Multicenter Trial
- Induction of Apoptosis by Korean Medicine Gagam-whanglyun-haedoktang Through Activation of Caspase-3 in Human Leukemia Cell Line, HL-60 Cells
- Ixeris dentata Green Sap Inhibits Both Compound 48/80-Induced Aanaphylaxis-Like Response and IgE-Mediated Anaphylactic Response in Murine Model
- Lupane Glycosides from the Leaves of Acanthopanax koreanum
- Styraxoside A Isolated from the Stem Bark of Styrax japonica Inhibits Lipopolysaccharide-Induced Expression of Inducible Nitric Oxide Synthase and Cyclooxygenase-2 in RAW 264.7 Cells by Suppressing Nuclear Factor-kappa B Activation(Pharmacognosy)
- 3-Oxoolean-12-en-27-oic Acid Isolated from Aceriphyllum rossii Induces Caspase-8-Dependent Apoptosis in Human Promyelocytic Leukemia HL-60 Cells(Pharmacognosy)
- Hypericin Induces Both Differentiation and Apoptosis in Human Promyelocytic Leukemia HL-60 Cells
- Effects of Dietary Supplementation of Lipophilic Fraction from Panax ginseng on cGMP and cAMP in Rat Platelets and on Blood Coagulation
- Effect of Ginsenoside Rb_1 on Rat Liver Phosphoproteins Induced by Carbon Tetrachloride
- Gluco-obtusifolin and Its Aglycon, Obtusifolin, Attenuate Scopolamine-Induced Memory Impairment
- Pectolinarin and Pectolinarigenin of Cirsium setidens Prevent the Hepatic Injury in Rats Caused by D-Galactosamine via an Antioxidant Mechanism(Pharmacognosy)
- Saucernetin-7 Isolated from Saururus chinensis Induces Caspase-Dependent Apoptosis in Human Promyelocytic Leukemia HL-60 Cells(Pharmacognosy)
- Development of a liquid chromatography/negative-ion electrospray tandem mass spectrometry assay for the determination of cilnidipine in human plasma and its application to a bioequivalence study
- Development and validation of a high-performance liquid chromatography-tandem mass spectrometry for the determination of penciclovir in human plasma : Application to a bioequivalence study
- An optimized analytical method of fluconazole in human plasma by high-performance liquid chromatography with ultraviolet detection and its application to a bioequivalence study
- Cell Growth of Ovarian Cancer Cells is Stimulated by Xenoestrogens through an Estrogen-Dependent Pathway, but Their Stimulation of Cell Growth Appears not to be Involved in the Activation of the Mitogen-Activated Protein Kinases ERK-1 and p38
- Costunolide-Induced Apoptosis in Human Leukemia Cells: Involvement of c-Jun N-Terminal Kinase Activation
- Costunolide Induces Apoptosis in Human Endometriotic Cells through Inhibition of the Prosurvival Akt and Nuclear Factor Kappa B Signaling Pathway
- Fraxinellone Inhibits Lipopolysaccharide-Induced Inducible Nitric Oxide Synthase and Cyclooxygenase-2 Expression by Negatively Regulating Nuclear Factor-kappa B in RAW 264.7 Macrophages Cells
- Absence of Clinical Prognostic Value of Vascular Endothelial Growth Factor and Microvessel Density in Multiple Myeloma
- 23-Hydroxytormentic Acid and Niga-Ichgoside F1 Isolated from Rubus coreanus Attenuate Cisplatin-Induced Cytotoxicity by Reducing Oxidative Stress in Renal Epithelial LLC-PK1 Cells
- Effects of Leucocyanidines on Activities of Metabolizing Enzymes and Antioxidant Enzymes
- Pleurospermum kamtschaticum Extract Induces Apoptosis via Mitochondrial Pathway and NAG-1 Expression in Colon Cancer Cells
- Rapid and simple method for determination of cephradine in human plasma using liquid chromatography-tandem mass spectrometry (LC-MS/MS) : Application to the bioequivalence study
- Development and validation of a high performance liquid chromatography-tandem mass spectrometry for the determination of etodolac in human plasma
- Validated method for determination of mazindol in human plasma by liquid chromatography/tandem mass spectrometry
- Quantification of roxatidine in human plasma by liquid chromatography electrospray ionization tandem mass spectrometry : Application to a bioequivalence study
- Anti-ulcerogenic Effect and HPLC Analysis of the Caffeoylquinic Acid-Rich Extract from Ligularia stenocephala
- The Ameliorative Effect of 23-Hydroxytormentic Acid Isolated from Rubus coreanus on Cisplatin-Induced Nephrotoxicity in Rats
- 3-Oxoolean-12-en-27-oic Acid Isolated from Aceriphyllum rossii Induces Caspase-8-Dependent Apoptosis in Human Promyelocytic Leukemia HL-60 Cells
- Pharmacological Characterization of BR-A-657, a Highly Potent Nonpeptide Angiotensin II Receptor Antagonist
- Fimasartan, Anti-hypertension Drug, Suppressed Inducible Nitric Oxide Synthase Expressions via Nuclear Factor-Kappa B and Activator Protein-1 Inactivation