Ixeris dentata Green Sap Inhibits Both Compound 48/80-Induced Aanaphylaxis-Like Response and IgE-Mediated Anaphylactic Response in Murine Model

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概要

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• We studied the inhibitory effect of the green sap of Ixeris dentata(IXD)on compound 48/80-induced anaphylaxis-like response in a murine model. IXD dose-dependently inhibited the anaphylaxis-like response induced by compound 48/80 in mice. IXD inhibited the anaphylaxis-like fatal response at the dose of 0.1 g/kg by 75%. IXD had a significant inhibitory effect on compound 48/80-induced ear swelling response at the doses of 0.05 and 0.1 g/kg. IXD(0.1 g/kg)also inhibited passive cutaneous anaphylaxis mediated by anti-dinitrophenyl IgE by 81.45%. When IXD was given as a pretreatment at concentrations ranging from 0.005 to 0.1 g/l, the histamine release from rat peritoneal mast cells induced by compoumd 48/80 was reduced in a dose-dependent manner. These results indicate that IXD may possess antianaphylactic activity.

• 社団法人日本薬学会の論文
• 2002-01-01

著者

• Jeong Hyun-ja

  Dep. Of Anatomy School Of Medicine Chonbuk National Univ.

• Kim Hyung-Min

  Department of Pharmacology, College of Oriental Medicine, Institute of Oriental Medicine, Kyung Hee

• Choi Jong-won

  韓国

• Hong Seung-heon

  Vestibulocochlear Research Center Of Wonkwang University

• Hong S‐h

  韓国

• Hong Seung-heon

  韓国

• Hong Seung-heon

  Department Of Oriental Pharmacy College Of Pharmacy Wonkwang University

• Na Ho-jeong

  韓国

• BAEK Seung-Hwa

  Department of Herbal Resources, Professional Graduate School of Oriental Medicine, Wonkwang Universi

• Kim Hyung-min

  韓国

• WON Jong-Heon

  Department of Biochemistry, College of Pharmacy, Kyung-Hee University

• Baek S‐h

  Department Of Biochemistry And Molecular Biology College Of Medicine Yeungnam University

• Baek Suk-hwan

  韓国

• Baek Seung-hwa

  Department Of Herbal Resources Professional Graduate School Of Oriental Medicine Wonkwang Univerisy

• Baek Seung-hwa

  韓国

• WON Jin-Hee

  College of Oriental Medicine, Wonkwang University

• Jung H‐s

  Division In Anatomy And Developmental Biology Department Of Oral Biology College Of Dentistry Yonsei

• Kim H‐m

  Kyung Hee Univ. Seoul Kor

• Kim Hyung

  College Of Oriental Medicine Kyung Hee University

• Kim Hyung-min

  Department Of Pharmacology College Of Oriental Medicine Kyung Hee University

• Won J‐h

  Department Of Biochemistry College Of Pharmacy Kyung-hee University

• Kim Jin-man

  Department Of Food And Nutrition College Of Health Sciences Korea University

• Jung Hyuk-sang

  Department Of Anatomy College Of Oriental Medicine Kyung Hee University

• Na Ho‐jeong

  College Of Pharmacy Wonkwang University

• Won Jin-hee

  College Of Oriental Medicine Wonkwang University

• LEE Hyo-Jeong

  Department of Oncology, Graduate School of East-West Medical Science, Kyunghee University

• KIM Joon-Bae

  Department of Pharmacology, College of Oriental Medicine, Kyung Hee University

• YI Jin-Mu

  Department of Oriental Pharmacy, College of Pharmacy, and Korea Institute of Oriental Pharmacy, Wonk

• KIM Joong-Man

  Laboratory of Food Processing and Preservation, College of Life Science and Natural Resources, Wonkw

• JEONE Dong-Myong

  Department of Electronic Engineering, Wonkwang University

• LIM Jong-Phil

  College of Pharmacy, Woosuk University

• Kim Hyung‐min

  Dep. Of Anatomy School Of Medicine Chonbuk National Univ.

• Kim Hyung-ryong

  Dep. Of Dental Pharmacology And Wonkwang Biomaterial Implant Res. Inst. School Of Dentistry Wonkwang

• Kim H.

  韓国

• Kim H‐m

  Yonsei Univ. School Of Medicine

• Kim Joong-man

  Department Of Pharmacology College Of Oriental Medicine Kyung Hee University

• Won Jong-heon

  韓国

• Yi Jin-mu

  Department Of Oriental Pharmacy College Of Pharmacy And Korea Institute Of Oriental Pharmacy Wonkwan

• So Hong-seob

  韓国

• Lee Hyo-jeong

  Department Of Oriental Pharmacy College Of Pharmacy And Korea Institute Of Oriental Pharmacy Wonkwan

• Lim Jong-phil

  College Of Pharmacy Woosuk University

• Jung H‐a

  Coll. Of Oriental Medicine And Inst. Of Oriental Medicine Kyung Hee Univ.

• Na Ho‐jeong

  Dep. Of Pharmacology Coll. Of Oriental Medicine Inst. Of Oriental Medicine Kyung Hee Univ.

• Kim Hong‐joon

  Department Of Veterinary Medicine College Of Life Sciences Research Institute For Subtropical Agricu

• Jeone Dong-myong

  Department Of Electronic Engineering Wonkwang University

• Lee Hyo-jeong

  Department Of Complementary And Alternative Therapy College Of Management Commerce And Social Welfar

• Shin H‐y

  Kyung Hee Univ. Seoul Kor

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