The Therapeutic Effect of Chelidonic Acid on Ulcerative Colitis
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概要
- 論文の詳細を見る
Chelidonic acid (CA), a constituent of Chelidonium majus L., has many pharmacological effects, including mild analgesic and antimicrobial effects. However, the effects of CA on intestinal inflammation and the molecular mechanisms responsible are poorly understood. The aim of this study was to investigate the protective effects of CA against dextran sulfate sodium (DSS)-induced ulcerative colitis (UC). Mice treated with DSS displayed obvious clinic signs, such as, body weight loss and a shortening of colon length, but the administration of CA attenuated both of these signs. Additionally, CA was found to regulate levels of interleukin-6 and tumor necrosis factor-α in serum. In colonic tissues, prostaglandin E2 (PGE2) production levels and cyclooxygenase-2 (COX-2) and hypoxia induced factor-1α (HIF-1α) expression levels were increased by DSS, but CA attenuated increases in COX-2 and HIF-1α levels. These results provide novel insights into the pharmacological actions of CA and its potential use for the treatment of intestinal inflammation.
著者
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Um Jae-Young
Department of Pharmacology, College of Oriental Medicine, Institute of Oriental Medicine, Kyung Hee
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Hong Seung-heon
Department Of Oriental Pharmacy College Of Pharmacy Wonkwang University
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Kim Su-jin
Department Of Atmospheric Sciences Yonsei University
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Kim Dae-Seung
Department of Oriental Pharmacy, College of Pharmacy, and Wonkwang Oriental Medicines Research Institute, Wonkwang University
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Um Jae-young
Department of Pharmacology, College of Oriental Medicine, Kyung Hee University
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Kim Su-Jin
Department of Cosmeceutical Science, Daegu Haany University
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Kim Min-Cheol
Department of Oriental Pharmacy, College of Pharmacy, and Wonkwang Oriental Medicines Research Institute, Wonkwang University
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Jeon Yong-Deok
Department of Oriental Pharmacy, College of Pharmacy, and Wonkwang Oriental Medicines Research Institute, Wonkwang University
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Hong Seung-Heon
Department of Oriental Pharmacy, College of Pharmacy, and Wonkwang Oriental Medicines Research Institute, Wonkwang University
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